Ensaios pré-clínicos em ratos tratados com 1,3-diestearil-2-oleil-glicerol, constituinte isolado de Platonia insiginis

Feitosa, Chistiane Mendes; Santos, Patrícia; Freitas, Rivelilson Mendes de; Rodrigues, Aldenora Maria Ximenes; de, Guilherme Antônio Lopes Oliveira; Costa, Joaquim Soares da; Cavalcante, Antônio do Nascimento

doi:10.5585/conssaude.v14n4.5658

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of TG1 as lipid matrix in the SLN formulations is due to this compound being extracted from butter of Platonia insignis , a natural species from Brazil. In studies performed by Feitosa et al (2015) [ 51 ], biochemical and hematological parameters were evaluated, as well as histopathological analysis in brain areas of adult rats treated orally with the TG1 triglyceride. The authors concluded that treatment with TG1 did not produce hematological, biochemical, or histopathological alterations in rats, suggesting low toxicity.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

et al. 2020

View full text Add to dashboard Cite

Phytol is a diterpene alcohol and can be found as a product of the metabolism of chlorophyll in plants. This compound has been explored as a potential antimicrobial agent, but it is insoluble in water. In this study, we describe a novel approach for an interesting anticandidal drug delivery system containing phytol. Different formulations of phytol-loaded solid lipid nanoparticles (SLN) were designed and tested using a natural lipid, 1,3-distearyl-2-oleyl-glycerol (TG1). Different compositions were considered to obtain three formulations with 1:10, 1:5, and 1:3 w/w phytol/TG1 ratios. All the formulations were prepared by emulsification solvent evaporation method and had their physicochemical properties assessed. The biocompatibility assay was performed in the HEK-293 cell line and the antifungal efficacy was demonstrated in different strains of Candida ssp., including different clinical isolates. Spherical and uniform SLN (<300 nm, PdI < 0.2) with phytol-loading efficiency >65% were achieved. Phytol-loaded SLN showed a dose-dependent cytotoxic effect in the HEK-293 cell line. The three tested formulations of phytol-loaded SLN considerably enhanced the minimal inhibitory concentration of phytol against 15 strains of Candida spp. Considering the clinical isolates, the formulations containing the highest phytol/TG1 ratios showed MICs at 100%. Thus, the feasibility and potential of phytol-loaded SLN was demonstrated in vitro, being a promising nanocarrier for phytol delivery from an anticandidal approach.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Here, two important aspects should be considered: the composition of the nanoparticles and their surface charge. The TG1, a constituent of the lipid matrix, is a triacyl glyceride of natural origin isolated from the plant Platonia insignis Mart [ 51 ]. There are few reports in the literature regarding its pharmacological properties.…”

Section: Resultsmentioning

confidence: 99%

Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

et al. 2020

View full text Add to dashboard Cite

show abstract

The Platonia insignis Mart. as the Promising Brazilian ‘Amazon Gold’: The State-of-the-Art and Prospects

Lima

Coêlho

Lucarini³

et al. 2022

Agriculture

View full text Add to dashboard Cite

Bacuri (Platonia insignis) is a monotype belonging to the Clusiaceae family. Of Amazonian origin, it is highly appreciated for fresh consumption, mainly due to its peculiar sensory characteristics. It is also widely used in the food industry, mainly in pulp (endocarp), used in the manufacture of beverages, jellies, and ice cream. Although the use of pulp is well established in the food sector, recently, research has turned attention to the use of other parts of the fruit and plant, especially in the therapeutics, cosmetics, and fuel sectors. Its bioactive components have been investigated for having important antioxidant, anti-inflammatory, immunomodulatory, hypotensive, cardioprotective, antiepileptic, antileishmanial, and antifungal activities, among others, mainly attributed to the presence of compounds such as xanthones, terpenes, phenolics, and fatty acids. Thus, this study aimed to gather data on the species Platonia insignis Mart. through an integrative review of the agronomic, nutritional, physical–chemical characteristics and a technological prospection about its applications. The study showed that in the last ten years there has been a significant increase in the number of patents deposited, with the prospect that with the advancement of studies on their properties, results for application in the most diverse areas will prove increasingly viable and promising.

show abstract

Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats

Lindoso

Alencar

Santos

et al. 2022

Biology

View full text Add to dashboard Cite

This study aimed to investigate the effects of oral administration of Platonia insignis Mart. (“bacuri”) seed butter (BSB) on oxidative stress and diabetes mellitus-related parameters in streptozotocin-induced (STZ) diabetic rats. Diabetes mellitus was induced in female Wistar rats (180–250 g) by the intraperitoneal administration of STZ (45 mg/kg, b.w). BSB (25, 50, and 100 mg/kg) was administered to animals for four weeks. The effect on weight gain, food intake, blood glucose, glycated hemoglobin, hepatic transaminases, plasma and liver TBARS and MPO activity, erythrocyte SOD activity, non-protein sulfhydryl groups (SH-NP), and histopathology of the liver tissue was investigated. BSB at the dose of 100 mg/kg had a positive effect on the reduction in glycated hemoglobin percentage and increased albumin concentration, as well as decreased ALT and AST levels and increased SH-NP liver levels in treated animals compared to normal control rats. Moreover, BSB had no effects on weight gain, food intake, and fasting glucose. Thus, the BSB presented marked properties in improvement of hepatic antioxidant defenses, which demonstrates BSB as a potential hepatoprotective agent in metabolic disorders.

show abstract

Ensaios pré-clínicos em ratos tratados com 1,3-diestearil-2-oleil-glicerol, constituinte isolado de Platonia insiginis

Cited by 3 publications

References 0 publications

Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

The Platonia insignis Mart. as the Promising Brazilian ‘Amazon Gold’: The State-of-the-Art and Prospects

Effects of “Bacuri” Seed Butter (Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats

Contact Info

Product

Resources

About