Enriched environment improves the cognitive effects from traumatic brain injury in mice

Schreiber, Shaul; Lin, Ran; Haim, Liron Naftali Ben; Baratz-Goldstien, R.; Rubovitch, Vardit; Vaisman, Nachum

doi:10.1016/j.bbr.2014.05.060

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…Between trials, the maze was cleaned using 95% ethanol and water and then dried. It was assumed that spatial memory was impaired when the activity in the novel arms was reduced 58 .…”

Section: Methodsmentioning

confidence: 99%

The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

Yang

Zhao

et al. 2016

Sci Rep

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Mental health disorders(MHD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have been widely studied. However, the underlying role of inflammatory cytokines and their associated signaling pathways have not been investigated. Here, we report the potential role of cytokines and associated signaling pathways in CP/CPPS patients with MHD and in a CP/CPPS animal model. CP/CPPS patients (n = 810) and control subjects (n = 992) were enrolled in this case-control multicenter study, and serum cytokine levels were measured. Male Sprague-Dawley rats received multiple intracutaneous injections of an immuno-agent along with a pertussis-diphtheria-tetanus triple vaccine for autoimmune CP/CPPS development. The results revealed that, in CP/CPPS patients with significant MHD, elevated IL-1α, IL-1β, IL-4, IL-13, and TNF-α serum levels were observed. The above five cytokines in CP/CPPS rats were significantly elevated in prostate tissue (p < 0.05), and IL-1β levels were elevated in serum and cerebrospinal fluid. In behavioral tests, CP/CPPS rats showed anxiety- and depression-like symptoms, and impaired spatial and associative memory performance (p < 0.05). In the CP/CPPS group, ERK1/2 phosphorylation levels were increased in the amygdala and nucleus accumbens, and decreased in the hippocampus, but not caudate nucleus. Thus, prostate-derived cytokines, especially IL-1β, cross the blood brain barrier and may lead to enhanced ERK1/2 signaling in several brain areas, possibly underlying induction of CP/CPPS-related MHD.

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“…Between trials, the maze was cleaned using 95% ethanol and water and then dried. It was assumed that spatial memory was impaired when the activity in the novel arms was reduced 58 .…”

Section: Methodsmentioning

confidence: 99%

The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

Yang

Zhao

et al. 2016

Sci Rep

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“…Secondary brain injury after trauma may result from oxidative stress, metabolic dysfunction, excitotoxicity, inflammatory response or vascular abnormalities [2,15,16]. Oxidative stress is caused by the generation of ROS in response to TBI [17,18,19]. High levels of ROS resulting from excitotoxicity and the failure of endogenous antioxidant mechanisms induce lipid peroxidation, protein nitration and DNA damage [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Lipid peroxidation level is typically determined by measuring the MDA content of brain mitochondria [17,24]. MDA levels begin to rise immediately after injury and remain elevated 24 and 48 h later [21,25].…”

Section: Discussionmentioning

confidence: 99%

Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in Mice

Zhai

Ding

Wang

et al. 2016

Neuroimmunomodulation

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Rutin reportedly conveys many beneficial effects, including neuroprotection in brain injury. However, the mechanisms underlying these effects are still not well understood. This study investigates the effect of rutin on potential mechanisms for neuroprotective effects, using the weight-drop model of traumatic brain injury (TBI) in male mice treated either with rutin or a vehicle via intraperitoneal injection 30 min after TBI. After euthanasia and 24 h after TBI, all mice were examined by tests, including neurologic scores, blood-brain barrier permeability, brain water content and neuronal cell death in the cerebral cortex. Results indicate that the levels of cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) were restored by rutin treatment. Rutin treatment resulted in the downregulation of caspase-3 expression in a reduced number of positive cells under terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay, and also the improved survival of neurons. Furthermore, pretreatment levels of MDA were restored, while Bcl-2-associated X protein translocation to mitochondria and cytochrome c release into cytosol were reduced by rutin treatment. Our results demonstrate that rutin improves neurological outcome by protecting neural cells against apoptosis via mechanisms that involve the mitochondria following TBI.

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“…Sensory stimulation activates affected neural networks, maximizing the potential for neural reorganization through brain plasticity (Di and Schnakers, 2012 ; Pham et al, 2014 ). Sensory stimulation programs provide enriched environments that optimize stimulation to encourage experience-dependent changes to the brain at neuroanatomical and biochemical levels (Renner and Rosenzweig, 1987 ; Nithianantharajah and Hannan, 2006 ; Schreiber et al, 2014 ). When working with children and youth with PDOC, developmental factors must be considered.…”

Section: Sensory Stimulation With Pediatric Docmentioning

confidence: 99%

Music in the Treatment of Children and Youth with Prolonged Disorders of Consciousness

Pool¹,

Magee

2016

Front. Psychol.

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Enriched environment improves the cognitive effects from traumatic brain injury in mice

Cited by 16 publications

References 29 publications

The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in Mice

Music in the Treatment of Children and Youth with Prolonged Disorders of Consciousness

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