“…Similar to reports on depressive-like behavior, the literature on anxiety in animal models of TLE is highly mixed. Across different rodent species, different timepoints, and different TLE models (e.g., dKA, intraperitoneal pilocarpine, intraperitoneal KA, amygdalar kindling, amygdalar KA), some studies report increased anxiety-like behavior ( Wintink et al, 2003 ; Mohajeri et al, 2004 ; Müller et al, 2009 ; Liu et al, 2013 ; Lopes et al, 2016 ; Otsuka et al, 2016 ), while others report decreased anxiety-like behavior ( Adamec et al, 2004 ; Detour et al, 2005 ; Dos Santos et al, 2005 ; Inostroza et al, 2011 , 2012 ; Vrinda et al, 2017 ). Differences in methods and models, as well as potentially in strains and species, undoubtedly play a role in the controversy ( Klee et al, 2017 ; Löscher et al, 2017 ).…”