Enoxaparin-associated spontaneous thigh haematoma

Antón, Enrique; Martí, Juan Manuel Torres

doi:10.1093/ageing/afh199

Cited by 9 publications

(3 citation statements)

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“… 5–11 Several reports of spontaneous unilateral lower extremity hematoma involved significantly older patients with one or more risk factors such as diabetes or kidney disease. 12–15 One of these studies also noted multiple sites of arterial extravasation. 12 However, this patient developed bilateral, simultaneous arterial hemorrhage from multiple small vessels without any history of trauma.…”

Section: Discussionmentioning

confidence: 98%

Bilateral spontaneous, simultaneous lower extremity hematomas in a patient on dalteparin

Daggett

Chung

Smith

2013

International Journal of Surgery Case Reports

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INTRODUCTIONBleeding related to low-molecular-weight heparins (LMWHs) is typically described as an excess of minor bleeding; however, several reports of spontaneous major bleeding have been noted.PRESENTATION OF CASEA 58-year-old female presented to the hospital with bilateral spontaneous lower extremity hematomas which rapidly enlarged. CT studies demonstrated active arterial extravasation from small vessels at multiple sites within each leg with no dominant feeding artery identified on either side. She required multiple transfusions, administration of protamine, fresh frozen plasma (FFP), recombinant activated Factor VII and eventual surgery.DISCUSSIONDalteparin provides an effective and economical method of anticoagulation, however there is a risk of significant, spontaneous arterial hemorrhage even in the absence of risk factors.CONCLUSIONDalteparin can cause major spontaneous bleeding from multiple arterial sources.

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Section: Discussionmentioning

confidence: 98%

Bilateral spontaneous, simultaneous lower extremity hematomas in a patient on dalteparin

Daggett

Chung

Smith

2013

International Journal of Surgery Case Reports

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“…The majority of cases if they are not related to trauma, surgery or puncture; are due to ruptured renal lesions (such as angiomyolipomas [7][8][9]; however, vascular disorders [10,11] and anticoagulation therapy [12][13][14][15][16][17][18], may also be the underlying cause. Sometimes is not possible to find an abnormality responsible for the bleeding [19] Renal tumours account for 58% to 79% of cases of non-traumatic retroperitoneal haemorrhage [7,20].…”

Section: Introductionmentioning

confidence: 99%

Case report: Delayed spontaneous retroperitoneal haematoma after unilateral total hip replacement

Fairén¹,

Duart²,

Alonso³

et al. 2017

Rheumatol Orthop Med

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We present the case of a 59-year-old woman who developed a major spontaneous retroperitoneal haematoma after performing a unilateral total hip arthroplasty. We reviewed the literature to see that a retroperitoneal haematoma is a rare event which can potentially be life-threatening.In our patient, the abdominal pain instead of being acute, as it happens on the majority of retroperitoneal haematomas, it started at day five postop associated to a sensation of abdominal fullness. An urgent CT was ordered to achieve de diagnose.A selective angiographic embolization was employed to stop the bleeding. Even if a total hip arthroplasty is a safe procedure, we need to be alert on operated patients with abdominal pain after the surgery and perform a careful evaluation.

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“…En los últimos años, en pacientes con insuficiencia renal se han descrito en forma creciente complicaciones hemorrágicas graves, incluso letales, con el uso de HBPM. Se han comunicado sangrados digestivos y hematomas de la pared abdominal, retroperitoneales, peri-renales, cerebrales, oculares, pericárdicos, del músculo ilio-psoas y epidurales [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] .…”

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Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?

2010

Rev. méd. Chile

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Are low-molecular-weight heparins safe in patients with chronic kidney disease? Due to their efficacy and convenience, low-molecular-weight heparins (LMWH) are used as sustitutes of unfractionated heparin. Unfortunately, most of the evidence about safety and usefulness of LMWH have excluded patients with chronic kidney disease (CKD), in whom their elimination clearance is reduced, allowing an increased anticoagulant effect. Accordingly, there is a growing number of reports about major and fatal bleeding episodes in this group of patients using LMWH. At the present stage of knowledge, there is no definitive cutoff value of renal function to adjust the doses or avoid the administration of LMWH, making their effects unpredictable in patients with CKD. Hence, it is reasonable to avoid the use of these drugs in patients with CKD, while awaiting for more evidence that supports their safer use.

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Enoxaparin-associated spontaneous thigh haematoma

Cited by 9 publications

References 0 publications

Bilateral spontaneous, simultaneous lower extremity hematomas in a patient on dalteparin

Bilateral spontaneous, simultaneous lower extremity hematomas in a patient on dalteparin

Case report: Delayed spontaneous retroperitoneal haematoma after unilateral total hip replacement

Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?

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