Enlarged basal ganglia perivascular spaces and sleep parameters. A population-based study

Brutto, Oscar H. Del; Mera, Robertino M.; Brutto, Victor J. Del; Castillo, Pablo R.

doi:10.1016/j.clineuro.2019.05.002

Cited by 45 publications

(35 citation statements)

References 26 publications

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“…Consistent with previous studies, our results showed that sleep quality was associated with CSVD and frailty ( Del Brutto et al, 2015 ; Shih et al, 2020 ). Several previous community-based studies revealed that subjective sleep quality was associated with WMH and EPVS ( Del Brutto et al, 2015 , 2019 ; Sexton et al, 2017 ). The proportion of insomnia in elderly with CSVD was far higher than that among general elders ( Wang et al, 2019 ).…”

Section: Discussionmentioning

confidence: 95%

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Zhao

Zhou

et al. 2021

Front. Aging Neurosci.

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Background: Physical frailty is a common problem among older adults which usually leads to adverse health outcomes. The imaging markers of cerebral small vessel disease (CSVD) are associated with frailty, but the underlying mechanisms remain unclear. The present study aimed to investigate the mediating role of sleep quality in the relationship between CSVD burden and frailty.Methods: We performed a cross-sectional study and enrolled community residents. Frailty and sleep quality were measured using the Fried frailty phenotype and the Pittsburgh Sleep Quality Index (PSQI), respectively. A multivariate linear regression analysis and a Bootstrap analysis were performed to examine the association among the key variables and the mediating role of sleep quality.Results: Of the 726 participants (mean age: 65.5 ± 6.5 years, 59.8% female), the numbers (percentages) of the frail, prefrail, and robust residents were 49 (6.7%), 310 (42.7%), and 367 (50.6%), respectively. After adjusting for covariates, the CSVD burden and PSQI score were significantly associated with the frailty score. In addition, sleep quality played a partial mediating role in the association between CSVD burden and physical frailty. The mediating effect was 21.9%.Conclusion: The present study suggests that sleep quality is a mediator of this association between CSVD and frailty in community-dwelling older adults. Improving sleep quality might be helpful to mitigate the risk of frailty in CSVD patients.

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Section: Discussionmentioning

confidence: 95%

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Zhao

Zhou

et al. 2021

Front. Aging Neurosci.

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“…(Iliff, et al, 2015) Increased PVS on MRI associate with SVD, hypertension, cognitive decline and dementia. (Debette, et al, 2018,Francis, et al, 2019,Passiak, et al, 2019 Increased PVS visibility was associated cross-sectionally with abnormal sleep efficiency in two studies on polysomnography, (Berezuk, et al, 2015,Del Brutto, et al, 2019 but an association with sleep quality did not survive co-variate adjustment in a larger sample of community-dwelling subjects. (Del Brutto, et al, 2019) Sleep efficiency reflects some elements of interrupted sleep that we found to be associated with increased basal ganglia PVS in co-variate-adjusted analysis in the present study.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 97%

“…(Debette, et al, 2018,Francis, et al, 2019,Passiak, et al, 2019 Two studies in patients with cerebrovascular disease and community-dwelling subjects (n=26 and n=97 respectively) found sleep abnormalities including sleep efficiency on polysomnography were associated with increased PVS visibility, (Berezuk, et al, 2015,Del Brutto, et al, 2019 and in a wider sample of 388 community-dwelling subjects including the 97 above, a univariate association between poor sleep quality and increased visible basal ganglia PVS was attenuated after co-variate adjustment. (Del Brutto, et al, 2019) Based on self-reported sleep habits, we found previously that increased daytime sleep duration was associated with slower processing speed cross-sectionally, and with decline in visuospatial processing between ages 70 and 76 in community-dwelling subjects. (Cox, et al, 2019) In the current analysis, we assessed the same community-dwelling subjects at age 76 for associations between self-reported sleep habits and vascular (PVS, WMH) or neurodegenerative (whole or subregional brain volume loss) changes on MRI.…”

Section: Introductionmentioning

confidence: 99%

Sleep and brain morphological changes in the eighth decade of life

et al. 2020

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Objective: Sleep is important for brain health. We analysed associations between usual sleep habits and MRI markers of neurodegeneration (brain atrophy), vascular damage (white matter hyperintensities, WMH) and waste clearance (perivascular spaces, PVS) in older communitydwelling adults. Method: We collected self-reported usual sleep duration, quality and medical histories from the Lothian Birth Cohort 1936 (LBC1936) age 76 years and performed brain MRI. We calculated sleep efficiency, measured WMH and brain volumes, quantified PVS, and assessed associations between sleep measures and brain markers in multivariate models adjusted for demographic and medical history variables. Results: In 457 subjects (53% males, mean age 76±0.65 years), we found: brain and white matter loss with increased weekend daytime sleep (β=-0.114, P=0.03; β=-0.122, P=0.007 respectively), white matter loss with less efficient sleep (β=0.132, P=0.011) and PVS increased with interrupted sleep (OR 1.84 95% CI, P=0.025). Conclusion:Cross-sectional associations of sleep parameters with brain atrophy and more PVS suggest adverse relationships between usual sleep habits and brain health in older people that should be evaluated longitudinally.

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“…59 Interestingly, enlargement of perivascular spaces in itself is connected to poor sleep quality. 60,61 A population study found that enlarged perivascular spaces and sleep disruptions are linked, and it was therefore hypothesised that sleep deficiency may lead to structural changes in the perivascular spaces. 61 Another study found a connection between the quantity of enlarged perivascular spaces and decreased sleep time.…”

Section: Neurodegeneration and Sleep Are Connected In A Bidirectional Mannermentioning

confidence: 99%

Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective

Kylkilahti

Berends

Ramos

et al. 2021

J Cereb Blood Flow Metab

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Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases. The glymphatic system is involved in clearance of metabolic by-products such as amyloid-β from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which corroborates findings from animal studies. We also review the importance of sleep, diet, vascular health for glymphatic clearance and find that these factors are also known players in brain longevity.

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Enlarged basal ganglia perivascular spaces and sleep parameters. A population-based study

Cited by 45 publications

References 26 publications

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Sleep Quality Mediates the Association Between Cerebral Small Vessel Disease Burden and Frailty: A Community-Based Study

Sleep and brain morphological changes in the eighth decade of life

Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective

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