Enkephalinergic-cholinergic interaction in the rat globus pallidus: a pre-embedding double-labeling immunocytochemistry study

Chang, Howard T.; Penny, G.R.; Kitai, S.T.

doi:10.1016/0006-8993(87)90443-4

Cited by 40 publications

(10 citation statements)

References 24 publications

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“…For example, GABAergic neurons have been shown to contain neuropeptide Y (Hendry et al, 1984;Somogyi et al, 1984;Alho et al, 1988), glutamic acid decarboxylase, and somatostatin immunoreactivities (Lin et al, 1986) as well as ChAT, and enkephalin-like immunoreactivities (Altschuler et al, 1984;Penny et al, 1986;Chang et al, 1987) have been co-localized. For the adult CNS the hypothesis is that ncuropeptides may be involved in the synthesis and rcleasc of neurotransmitter substances.…”

Section: Resultsmentioning

confidence: 97%

Opioids influence neurotransmitter phenotypic expression in chick embryonic neuronal cultures

Vernadakis

Kentroti

1990

J of Neuroscience Research

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There is considerable interest in the role of endogenous opioid peptides in neural growth and differentiation. In this study we used neuron-enriched cultures derived from 3-day-old chick embryos to test the effects of endogenous enkephalins on neurotransmitter phenotypic expression. Cultures were grown in serum-free chemically defined medium and were treated with either Met-enkephalin antiserum (anti-Met) to immunoneutralize enkephalins, or with naloxone, a universal opioid receptor antagonist, to block receptor-mediated actions of released endogenous opioids. The enzyme activities of choline acetyltransferase (ChAT) and tyrosine hydroxylase (TH) were used as markers for cholinergic and catecholaminergic phenotypic expression, respectively. We found that cultures treated with anti-Met or naloxone exhibited strikingly different neuronal growth patterns as compared to controls. In addition, ChAT activity was enhanced by anti-Met, and TH activity by both anti-Met and naloxone. These findings lend support to the possibility that neuropeptides may be co-localized with neurotransmitters and that peptides released into the microenvironment affect neuronal phenotypic expression by differential receptor subtypes.

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Section: Resultsmentioning

confidence: 97%

Opioids influence neurotransmitter phenotypic expression in chick embryonic neuronal cultures

Vernadakis

Kentroti

1990

J of Neuroscience Research

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“…Finally, axons from ventral regions of the VS terminate in the nucleus basalis. This connection has been demonstrated at the light microscopic level in monkeys and verified at the Reward circuit: linking primate anatomy and human imaging SN Haber and B Knutson .......................................................................................................................................................... EM level in rodents (Beach et al, 1987;Chang et al, 1987;Haber, 1987;Martinez-Murillo et al, 1988;Zaborszky and Cullinan, 1992). A projection to the nucleus basalis in the basal forebrain is of particular interest, since this is the main source of cholinergic fibers to the cerebral cortex and the amygdala.…”

Section: Connections Of the Vsmentioning

confidence: 99%

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Haber

Knutson

2009

Neuropsychopharmacol

3,135

193

2,859

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Although cells in many brain regions respond to reward, the cortical-basal ganglia circuit is at the heart of the reward system. The key structures in this network are the anterior cingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, and the midbrain dopamine neurons. In addition, other structures, including the dorsal prefrontal cortex, amygdala, hippocampus, thalamus, and lateral habenular nucleus, and specific brainstem structures such as the pedunculopontine nucleus, and the raphe nucleus, are key components in regulating the reward circuit. Connectivity between these areas forms a complex neural network that mediates different aspects of reward processing. Advances in neuroimaging techniques allow better spatial and temporal resolution. These studies now demonstrate that human functional and structural imaging results map increasingly close to primate anatomy.

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“…Glutamatergic synapses onto cholinergic neurons have been recently described, visualizing both VGLUT-1 and VGLUT-2 transporters presynaptically (Hur et al, 2009). Additionally, GABA (Zaborszky et al, 1986), substance P (Bolam et al, 1986), enkephalin (Chang et al, 1987;Martinez-Murillo et al, 1988), somatostatin (SS) and NPY synapses onto BF cholinergic neurons have been described. Cholinergic neurons in the septum receive and are excited by orexin/hypocretin terminals (Khateb et al, 1995;Eggermann et al, 2001;Wu et al, 2004).…”

Section: Afferents In the Basal Forebrain Show Regionally Restricted mentioning

confidence: 98%

Organization of the Basal Forebrain Cholinergic Projection System

Záborszky

Duque

Gielow

et al. 2015

The Rat Nervous System

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Enkephalinergic-cholinergic interaction in the rat globus pallidus: a pre-embedding double-labeling immunocytochemistry study

Cited by 40 publications

References 24 publications

Opioids influence neurotransmitter phenotypic expression in chick embryonic neuronal cultures

Opioids influence neurotransmitter phenotypic expression in chick embryonic neuronal cultures

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Organization of the Basal Forebrain Cholinergic Projection System

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