Enhancing the nanoplasmonic signal by a nanoparticle sandwiching strategy to detect viruses

İnci, Fatih; Karaaslan, Merve Gökşin; Mataji-Kojouri, Amideddin; Shah, Pir Ahmad; Saylan, Yeşeren; Zeng, Yitian; Avadhani, Anirudh; Sinclair, Robert; Lau, Daryl; Demirci, Utkan

doi:10.1016/j.apmt.2020.100709

Cited by 29 publications

(21 citation statements)

References 44 publications

(53 reference statements)

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“…As demonstrated in Figure 1, a target analyte principally binds to the recognition element (receptor), and the sensing component specifically recognizes the analyte by a reaction, specific adsorption, or another process as physical and/or chemical and then the transducer translates changes to a quantifiable signal measured by the digital detector module [40]. Sensors have numerous advantages, including user-friendly operation, exceptional performance, rapid response, minimum sample preparation and processing, portability, high sensitivity and specificity, relatively compact size, and real-time analysis that provide many advantages compared to standard analytical methods [41][42][43][44][45]. Furthermore, they have a great impact on the environment, medical, safety, and many other applications [46][47][48].…”

Section: Principle Of Sensorsmentioning

confidence: 99%

“…[52]. Plasmonic sensors Sensors have numerous advantages, including user-friendly operation, exceptional performance, rapid response, minimum sample preparation and processing, portability, high sensitivity and specificity, relatively compact size, and real-time analysis that provide many advantages compared to standard analytical methods [41][42][43][44][45]. Furthermore, they have a great impact on the environment, medical, safety, and many other applications [46][47][48].…”

Section: Principle Of Sensorsmentioning

confidence: 99%

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Plasmonic Sensors for Monitoring Biological and Chemical Threat Agents

2020

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Sensors are excellent options owing to their ability to figure out a large number of problems and challenges in several areas, including homeland security, defense, medicine, pharmacology, industry, environment, agriculture, food safety, and so on. Plasmonic sensors are used as detection devices that have important properties, such as rapid recognition, real-time analysis, no need labels, sensitive and selective sensing, portability, and, more importantly, simplicity in identifying target analytes. This review summarizes the state-of-art molecular recognition of biological and chemical threat agents. For this purpose, the principle of the plasmonic sensor is briefly explained and then the use of plasmonic sensors in the monitoring of a broad range of biological and chemical threat agents is extensively discussed with different types of threats according to the latest literature. A conclusion and future perspectives are added at the end of the review.

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Section: Principle Of Sensorsmentioning

confidence: 99%

Section: Principle Of Sensorsmentioning

confidence: 99%

Plasmonic Sensors for Monitoring Biological and Chemical Threat Agents

2020

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“…They widely performed theoretical simulations and kinetic calculations to test biosensor performance and then provided simple configuration for user‐interface, label‐free detection, short assay‐time, facile sampling and inexpensive chips. They also mentioned that this optical medical biosensor can accelerate the spreading of portable systems for medical applications (Inci, et al, 2020; Inci, et al, 2020). Çimen et al determined cardiac troponin I by optical medical biosensor using anti‐cardiac troponin I monoclonal antibody.…”

Section: Recent Studies Of Medical Biosensorsmentioning

confidence: 99%

“…The molecular interactions happen between a target structure and a recognition element that produce a signal to assess their structure, composition and function of biomolecules such as regulating biological activities, transporting molecules, storing and transmitting genetic information, and also catalysing reactions. Besides, they can be employed as biomarkers in the diagnosis of several diseases (Chen et al, 2020; Inci, et al, 2020; Inci, et al, 2020; Su et al, 2020; Tran et al, 2020). Despite their use in various fields is still in the early stages, biosensors have different applications in medicine.…”

Section: Introductionmentioning

confidence: 99%

Recent advances of medical biosensors for clinical applications

2020

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The growing requirements for sensing of biomolecules need the development of sensitive, selective, precise, fast and easy-to-use innovative analytical tools for clinical applications Thaler & Luppa, 2019). Quantitative measurements of biomolecules are generally carried out by conventional methods including spectroscopic and chromatographic techniques for extraction, separation and detection Karami et al., 2020;Liu et al., 2019). These conventional techniques are sensitive; however, they require complicated and expensive pieces of equipment and also need expert staff and time to operate them with sample preparation (Eivazzadeh-Keihan et al., 2019;Soler et al., 2020). It is hard to achieve real-time detection of biomolecules by these techniques.New tools with superior sensing capabilities and high spatial localization are urgently needed for especially clinical applications (Rico-Yuste & Carrasco, 2019). The development of biosensors and also powerful, automated and cost-effective diagnostic platforms for the fast and real-time detection of biomolecules have been struggling by researchers Samson et al., 2020;Wang et al., 2020). The scientists from all over the world combine chemistry, biology, physics, electronics, material science, biotechnology and nanotechnology to follow recent developments due to their specific properties of sensing abilities (

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“…In such a scenario, the test result is typically not available to the patient until the next day. Therefore, decentralized testing is highly required as a point-of-care (PoC) concept for the rapid and accurate detection of such diseases [ 5 , 13 , 14 ] and any conditions requiring further downstream analyses [ 15 , 16 , 17 , 18 ]. Recently, considerable attempts have been made to manufacture PoC platforms for CD diagnostic and monitoring.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases

et al. 2021

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Chronic diseases (CDs) are noncommunicable illnesses with long-term symptoms accounting for ~70% of all deaths worldwide. For the diagnosis and prognosis of CDs, accurate biomarker detection is essential. Currently, the detection of CD-associated biomarkers is employed through complex platforms with certain limitations in their applicability and performance. There is hence unmet need to present innovative strategies that are applicable to the point-of-care (PoC) settings, and also, provide the precise detection of biomarkers. On the other hand, especially at PoC settings, microneedle (MN) technology, which comprises micron-size needles arranged on a miniature patch, has risen as a revolutionary approach in biosensing strategies, opening novel horizons to improve the existing PoC devices. Various MN-based platforms have been manufactured for distinctive purposes employing several techniques and materials. The development of MN-based biosensors for real-time monitoring of CD-associated biomarkers has garnered huge attention in recent years. Herein, we summarize basic concepts of MNs, including microfabrication techniques, design parameters, and their mechanism of action as a biosensing platform for CD diagnosis. Moreover, recent advances in the use of MNs for CD diagnosis are introduced and finally relevant clinical trials carried out using MNs as biosensing devices are highlighted. This review aims to address the potential use of MNs in CD diagnosis.

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Enhancing the nanoplasmonic signal by a nanoparticle sandwiching strategy to detect viruses

Cited by 29 publications

References 44 publications

Plasmonic Sensors for Monitoring Biological and Chemical Threat Agents

Plasmonic Sensors for Monitoring Biological and Chemical Threat Agents

Recent advances of medical biosensors for clinical applications

Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases

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