Enhancing the buccal mucosal uptake and retention of triamcinolone acetonide

Nicolazzo, Joseph A.; Reed, Barry L.; Finnin, Barrie C.

doi:10.1016/j.jconrel.2005.03.022

Cited by 57 publications

(33 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Ho (24), lipophilic compounds (e.g., TAC) would have a rapid uptake by partitioning into the buccal epithelium, followed by tissue retention, and slow transfer into the systemic circulation. The same behavior was observed by Nicolazzo et al (22), who found a disappearance rate of TAC from the donor chamber higher than the appearance rate in the receptor chamber (approximately 18.8 times), indicating a high retention of this drug in buccal mucosa. The addition of ethanol in the receptor chamber increased the throughput of TAC from the underlying layers of the epithelium since a lag time reduction (within the range of 0.65 to 1.29 h) was shown (Table II).…”

Section: Permeability Of Triamcinolone Acetonide Through Buccal and Esupporting

confidence: 86%

“…Even though some studies have evaluated the distribution and permeability of TAC through the buccal mucosa (22,23), the present study aimed to optimize the permeability of TAC in order to calculate its permeability parameters (flux, permeability coefficient, lag time) with greater reliability and also to reduce the experimental time. According to Nicolazzo et al (22), the permeated amount of this drug is reduced and close to the quantification limit when absorption enhancers are not used.…”

Section: Permeability Of Triamcinolone Acetonide Through Buccal and Ementioning

confidence: 99%

“…Thus, ethanol was tested to this purpose. The retention analysis of TAC in buccal mucosa was not evaluated in this study given that it was already reported (22).…”

Section: Permeability Of Triamcinolone Acetonide Through Buccal and Ementioning

confidence: 99%

See 2 more Smart Citations

Effect of Freezing and Type of Mucosa on Ex Vivo Drug Permeability Parameters

Caon

Simões

2011

AAPS PharmSciTech

View full text Add to dashboard Cite

Abstract. The porcine esophageal mucosa has been proposed as a substitute for the buccal mucosa barrier on ex vivo permeability studies mainly due to its large surface area as well as its easier preparation. Therefore, this study compared the ex vivo permeability parameters of two drugs (carmabazepine (CBZ) and triamcinolone acetonide (TAC)) with different permeabilities and physicochemical properties through buccal and esophageal mucosae using a Franz diffusion cell system and HPLC as detection method. The freezing effects on drug permeability parameters were also evaluated by comparing them when fresh and frozen tissues were used. The barrier properties were not affected by the freezing process since the obtained parameters for both drugs were similar in frozen and fresh tissues (buccal and esophageal mucosae). However, an increase of CBZ retention was shown in frozen tissues. Fresh and frozen esophageal mucosae provided higher permeation of TAC than on buccal mucosae while the obtained permeability parameters for CBZ were similar on both mucosae. According to our results, porcine esophageal mucosa could be used as a substitute for buccal mucosa on ex vivo studies involving CBZ but not TAC. Frozen tissues could be used as substitute for fresh tissues in both cases. However, any substitution should be done with care and only if previous tests were performed, because the results could differ depending on the tested drug.

show abstract

Section: Permeability Of Triamcinolone Acetonide Through Buccal and Esupporting

confidence: 86%

Section: Permeability Of Triamcinolone Acetonide Through Buccal and Ementioning

confidence: 99%

See 1 more Smart Citation

Effect of Freezing and Type of Mucosa on Ex Vivo Drug Permeability Parameters

Caon

Simões

2011

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…In order to improve drug delivery to this route, the tissue may be treated with penetration enhancers (PE). The retention of other lipophilic drugs as estradiol (20) and triamcinolone acetonide (21) in mucosal tissue was improved by association with PE as Azone® (Az) or laurocapram, a derivative of the ethoxylated nonionic surfactant Span 20 in buccal mucosa local therapy (20,21). Increased drug retention on the buccal mucosa by its capacity to overcome the mucous barrier layer, or increased drug partition to the target tissue, is one of the described mechanisms for the Az effect.…”

Section: Celecoxib (Cx) or 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-mentioning

confidence: 99%

In Vitro Characterization of Chitosan Gels for Buccal Delivery of Celecoxib: Influence of a Penetration Enhancer

et al. 2011

View full text Add to dashboard Cite

Abstract. Celecoxib (Cx) shows high efficacy in the treatment of osteoarthritis and rheumatoid arthritis as a result of its high specificity for COX-2, without gastrolesivity or interference with platelet function at therapeutic concentrations. Besides of anti-inflammatory effects, Cx also has a potential role for oral cancer chemoprevention. For these conditions, oral administration in long-term treatment is a concern due to its systemic side effects. However, local application at the site of injury (e.g., buccal inflammation conditions or chemoprevention of oral cancer) is a promising way to reduce its toxicity. In this study, the in vitro characterization of mucoadhesive chitosan (CHT) gels associated to Azone® was assessed to explore the potential buccal mucosal administration of Cx in this tissue. Rheological properties of gels were analyzed by a rheometer with cone-plate geometry. In vitro Cx release and permeability studies used artificial membranes and pig cheek mucosa, respectively. Mucoadhesion were measured with a universal test machine. CHT gels (3.0%) containing 2.0% or 3.0% Az showed more appropriate characteristics compared to the others: pH values, rheology, higher amount of Cx retained in the mucosa, and minimal permeation through mucosa, besides the highest mucoadhesion values, ideal for buccal application. Moreover, the flux (J) and amounts of drug released decreased with increased CHT and Az concentrations. CHT gels (3.0%) associated with 2.0% or 3.0% Az may be considered potential delivery systems for buccal administration of Cx.

show abstract

“…Topical administration to the oral mucous membrane is an alternative route that aims to avoid systemic side effects, which also has the advantage of effectively treating local lesions. [7][8][9] No topical preparations to be applied to the oral cavity for relieving pain caused by oral mucositis are commercially available. Topical preparations containing NSAIDs to relieve pain such as sprays, gels and solutions have been formulated in hospital preparations 5,6) and previous studies have developed mucoadhesive films.…”

mentioning

confidence: 99%

Development of Polyethylene Glycol and Hard Fat-Based Mucoadhesive Tablets Containing Various Types of Polyvinyl Alcohols as Mucoadhesive Polymers for Buccal Application

Ikeuchi-Takahashi

Kobayashi

Onishi

2017

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Topical drug application has the advantage of avoiding systemic side effects. We attempted to develop a long-acting matrix-type tablet containing indomethacin (IM) with low physical stimulus and potent mucoadhesive force to treat pain caused by oral aphtha. A mixture of polyethylene glycol (PEG) and hard fat was used as the tablet base. Ethylcellulose was added to the base in an attempt to control drug release. Tablets with PEG as a base were also prepared for comparison. Polyvinyl alcohols (PVAs) with various degrees of saponification were added to increase the mucoadhesive force. From the optical microscopic observations, formulations using PEG and hard fat exhibit PEG/hard fat dispersions caused by the stabilizing effects of PVA. Although the tablets using PEG and hard fat showed sufficient adhesiveness and sustained drug release, those using PEG as the base did not. Drug release was controlled by the amount of hard fat and the saponification degree of PVA. The drug release rate was most increased in a tablet containing PVA with an intermediate degree of saponification, PEG and hard fat. From differential scanning calorimetry and powder X-ray diffraction, IM was considered to exist in the molecular phase. From the results of buccal administration of tablets to rats, highest tissue concentrations were observed in the tablet containing PVA with the intermediate degree of saponification using PEG and hard fat, and the plasma concentrations were sufficiently low in comparison.

show abstract

Enhancing the buccal mucosal uptake and retention of triamcinolone acetonide

Cited by 57 publications

References 35 publications

Effect of Freezing and Type of Mucosa on Ex Vivo Drug Permeability Parameters

Effect of Freezing and Type of Mucosa on Ex Vivo Drug Permeability Parameters

In Vitro Characterization of Chitosan Gels for Buccal Delivery of Celecoxib: Influence of a Penetration Enhancer

Development of Polyethylene Glycol and Hard Fat-Based Mucoadhesive Tablets Containing Various Types of Polyvinyl Alcohols as Mucoadhesive Polymers for Buccal Application

Contact Info

Product

Resources

About