In Vitro Characterization of Chitosan Gels for Buccal Delivery of Celecoxib: Influence of a Penetration Enhancer

Cid, Yara Peluso; Pedrazzi, Vinícius; Sousa, Valéria Pereira de; Pierre, Maria Bernadete Riemma

doi:10.1208/s12249-011-9725-8

Cited by 43 publications

(49 citation statements)

References 50 publications

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“…CXB is highly lipophilic (logP value of 4.21), and could be retained in superficial skin layers (1). Very lipophilic drugs enter into the stratum corneum, but these drugs remain in this superficial layer and do not reach the deep layers of the skin.…”

Section: Discussionmentioning

confidence: 99%

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Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies

et al. 2014

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Abstract. Liquid crystalline systems of monoolein/water could be a promising approach for the delivery of celecoxib (CXB) to the skin because these systems can sustain drug release, improve drug penetration into the skin layers and minimize side effects. This study evaluated the potential of these systems for the delivery of CXB into the skin based on in vitro drug release and skin permeation studies. The amount of CXB that permeated into and/or was retained in the skin was assayed using an HPLC method. Polarizing light microscopy studies showed that liquid crystalline systems of monoolein/water were formed in the presence of CXB, without any changes in the mesophases. The liquid crystalline systems decreased drug release when compared to control solution. Drug release was independent of the initial water content of the systems and CXB was released from cubic phase systems, irrespective of the initial water content. The systems released the CXB following zero-order release kinetics. In vitro drug permeation studies showed that cubic phase systems allowed drug permeation and retention in the skin layers. Cubic phase systems of monoolein/water may be promising vehicles for the delivery of CXB in/through the skin because it improved CXB skin permeation compared with the control solution.

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Section: Discussionmentioning

confidence: 99%

“…CXB also has chemopreventive activity against some types of cancer, such as ultraviolet B radiation-induced skin cancer and breast cancer. The activity of CXB is due to the selective inhibition of cyclooxygenase (COX-2) activity (1)(2)(3). Currently, CXB is marketed in a conventional capsule form for oral administration.…”

Section: Introductionmentioning

confidence: 99%

Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies

et al. 2014

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“…Cid et al [89] explored chitosan gels for buccal delivery of the highly lipophilic celecoxib, a COX-2 inhibitor, for oral cancer chemoprevention. Laurocapram (Azone ® ), a nonionic surfactant, was added to this formulation as a penetration enhancer in order to increase uptake of the drug in the buccal mucosa.…”

Section: Oral Cancermentioning

confidence: 99%

Advanced Drug Delivery Systems for Local Treatment of the Oral Cavity

2015

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Good oral health is of major importance for general health and well-being. Several innovative drug delivery systems have been developed for the local treatment and prevention of various diseases in the oral cavity. However, there are currently few optimal systems and many therapeutic challenges still remain, including low drug efficacy and retention at targeted site of action. The present review provides an insight into the latest drug delivery strategies for the local treatment and prevention of the four most common oral pathologies, namely, dental caries, periodontitis, oral mucosal infections and oral cancer. The potential of bioadhesive formulations, nanoparticulate platforms, multifunctional systems and photodynamic methodologies to improve therapy and prophylaxis in future local applications for the oral cavity will be discussed.

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“…To overcome these challenges, bioadhesive formulations are designed to reduce the frequency of administrations and improve patient compliance. The excellent property of chitosan can not only improve adhesion to the mucosa but also enhance the permeation of drugs (Senel et al 2000;Cid et al 2012). Chitosan gels containing transforming growth factor-β (TGF-β) were used for mucosal drug delivery and the permeability of TGF-β across buccal mucosa was increased by six fold (Senel et al 2000).…”

Section: Oral Deliverymentioning

confidence: 99%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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The development of drug delivery systems always goes hand in hand with the advancement of material science. The novel synthetic or natural functional materials provide opportunities to design optimal drug delivery systems. Among these, chitosan and its derivatives exhibit excellent application future because of its prominent characteristics. In this chapter, research progress of chitosan and its derivatives for drug delivery, from structure to properties, from properties to its application were overviewed. The physicochemical properties, biological properties, biodegradability, safety evaluation and structure modification of chitosan were introduced. Furthermore, applications of chitosan and its derivatives in drug delivery including as the carrier of nanoparticles and microparticles, as coating material, as matrix of hydrogels, films and sustained release tablets, as stabilizers, as absorption enhancers, were discussed. Finally, the applications of chitosan and its derivatives in different administration routes, and their advantages for gene, protein and vaccine delivery, were reviewed. The numerous successful studies on exploitation and application of chitosan and its derivatives showed promising application future of these materials in drug delivery.

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In Vitro Characterization of Chitosan Gels for Buccal Delivery of Celecoxib: Influence of a Penetration Enhancer

Cited by 43 publications

References 50 publications

Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies

Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies

Advanced Drug Delivery Systems for Local Treatment of the Oral Cavity

Drug Delivery Applications of Chitosan and its Derivatives

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