Enhancing sensitivity in absorption spectroscopy using a scattering cavity

Oh, Jeong-hun; Lee, KyeoReh; Park, YongKeun

doi:10.1038/s41598-021-94028-4

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…The use of multiple light scattering to enhance optical signals has been utilized to overcome the sensitivity limitations of conventional optical devices ( 18 ), including scattering super lenses ( 19 ), temperature sensors ( 20 ), pressure sensors ( 21 ), wavelength meters ( 22 ), fiber-based spectrometers ( 23 ), absorption spectrometers ( 24 ), and nonresonant lasers ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Rapid Bacterial Detection in Urine Using Laser Scattering and Deep Learning Analysis

Lee

Lim²,

Kim

et al. 2022

Microbiol Spectr

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This study performed deep learning of multiple laser scattering patterns by the bacteria in urine to predict positive urine culture. Conventional urine analyzers have limited performance in identifying bacteria in urine. This novel method showed a satisfactory accuracy taking only 30 min of analysis without conventional urine culture. It was also developed to predict the Gram staining reaction of the bacteria. It can be used as a standalone screening tool for urinary tract infection.

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Section: Discussionmentioning

confidence: 99%

Rapid Bacterial Detection in Urine Using Laser Scattering and Deep Learning Analysis

Lee

Lim²,

Kim

et al. 2022

Microbiol Spectr

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“…As demonstrated in previous studies, many of these approaches aim to alleviate the problems of light scattering and replicate the effects observed in an integrating sphere [34][35][36], as well as to enhance the sensitivity of absorption spectroscopy. In particular, the latter is achieved through a method known as multiscattering-enhanced absorption spectroscopy (MEAS), which involves dispersing gold nanoparticles in the sample solution [37] or surrounding the sample with a scattering cavity [38] to increase the PL and thereby enhance detection sensitivity.…”

Section: Introductionmentioning

confidence: 99%

High-Dynamic-Range Absorption Spectroscopy by Generating a Wide Path-Length Distribution with Scatterers

Mori,

Yamashita,

Tokunaga

2024

Photonics

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In absorption spectroscopy, it is challenging to detect absorption peaks with significant differences in their intensity in a single measurement. We enable high-dynamic-range measurements by dispersing scatterers within a sample to create a broad distribution of path lengths (PLs). The sample is placed within an integrating sphere (IS) to capture all scattered light of various PLs. To address the complexities of PLs inside the IS and the sample, we performed a ray-tracing simulation using the Monte Carlo (MC) method, which estimates the measured absorbance A and PL distribution from the sample’s absorption coefficient µa and scattering properties at each wavelength λ. This method was validated using dye solutions with two absorption peaks whose intensity ratio is 95:1, employing polystyrene microspheres (PSs) as scatterers. The results confirmed that both peak shapes were delineated in a single measurement without flattening the high absorption peak. Although the measured peak shapes A(λ) did not align with the actual peak shapes µa(λ), MC enabled the reproduction of µa(λ) from A(λ). Furthermore, the analysis of the PL distribution by MC shows that adding scatterers broadens the distribution and shifts it toward shorter PLs as absorption increases, effectively adjusting it to µa.

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“…Wavemeters based on an integrating sphere have been used to demonstrate sub-femtometer resolution [7,8], yet size and stability requirements limit applications to specialist and laboratory settings. Since 2013, a compact spectrometer chip based on a silicon-on-insulator scattering medium has been utilised to increase the optical path length and enable better spectral resolution within the same physical space [9,10]. The first version of such a device was designed as a two-dimensional random air holes etched into the silicon plane [3].…”

Section: Introductionmentioning

confidence: 99%

Compact nano-void spectrometer based on a stable engineered scattering system

Qi¹,

Falak²,

Vettenburg

et al. 2022

Photon. Res.

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Random scattering of light in disordered media can be used for highly sensitive speckle-based wavemeters and spectrometers. However, the multiple scattering events that fold long optical paths within a compact space also make such devices exceedingly sensitive to vibrations and small disturbances to the disordered media. Here, we show how scattering can be engineered so that it can be used for a compact computational spectrometer that is largely insensitive to environmental factors. We designed and fabricated a three-dimensional pseudo-random nano-void pattern with 62% scattering efficiency. The controlled amount of multiple scattering ensured a sufficiently long optical path for the target resolution of 100 pm, with optimal long-term stability. The 200-μm-thick scattering silica substrate was integrated in a compact assembly with a low-cost camera sensor. The target resolution was achieved for full spectrum measurements while single wavelengths could be determined with 50 pm resolution. Such tailored scattering systems can improve the trade-off among cost, size, stability, and spectral resolution in computational spectrometers.

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Enhancing sensitivity in absorption spectroscopy using a scattering cavity

Cited by 7 publications

References 51 publications

Rapid Bacterial Detection in Urine Using Laser Scattering and Deep Learning Analysis

Rapid Bacterial Detection in Urine Using Laser Scattering and Deep Learning Analysis

High-Dynamic-Range Absorption Spectroscopy by Generating a Wide Path-Length Distribution with Scatterers

Compact nano-void spectrometer based on a stable engineered scattering system

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