Enhancing Prostate‐Cancer‐Specific MRI by Genetic Amplified Nanoparticle Tumor Homing

Zhao, Yang; Peng, Jing; Yang, Jin-Yi; Zhang, Enlong; Huang, Ling; Yang, Hong; Kakadiaris, Eugenia; Li, Jingjin; Yan, Bin; Shang, Zhiqun; Jiang, Ning; Zhang, Xuening; Han, Gang; Niu, Yuanjie

doi:10.1002/adma.201900928

Cited by 21 publications

(15 citation statements)

References 38 publications

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“…The use of storytelling has a significant effect on conveying messages of change to the measurement after the intervention to followers. This is in accordance with the opinion of Zhao et al, (2019) which states that stories help someone to understand something complex because stories are easy to remember, are not hierarchical and are general in nature. This story is also able to bring people to the same understanding, empathize with other people's experiences and ultimately be able to change one's perception.…”

Section: Benefits Of Storytellingsupporting

confidence: 90%

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Storytelling through the Tik Tok Application Affects Followers’ Behaviour Changes

Triwidyati

Pangastuti

2021

Jurnal Ekonomi & Bisnis JAGADITHA

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Storytelling is an art that is becoming a trend on social media, nowadays it is starting to be abandoned by switching to story style uploaded via Facebook, Instagram and Tiktok, which have more fans and followers because the story style is clear and solid. Storytelling through the media is a means of influencing audience affection. The storytelling content conveyed includes an event, experience, or inspirational story that is shared by a Tik Tok account owner to his/her followers. This study aims to examine the storytelling through the Tiktok application affects followers’ behavior changes. The method used in this study is a qualitative method in which the research data is in the form of information obtained from followers of the Tiktok application related to the context discussed in the video in the Tiktok application. The method of determining the sample of purposive informants is done by determining the research informants deliberately based on predetermined criteria. The result of the storytelling data is the process of building a story that is easily understood and understood successfully to convince the audience that there is value in an action plan that can be carried out. The story is supported by facts and appropriate analysis data. Based on the results obtained from this study, it was found that storytelling was effective in conveying messages of positive change and as it was, there was no fraud or engineering to the followers and came up with very creative ideas.

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Section: Benefits Of Storytellingsupporting

confidence: 90%

“…The Tik Tok application can become popular culture in Indonesia, for several reasons, namely (Zhao et al, 2019).…”

Section: Storytelling Through Social Mediamentioning

confidence: 99%

Storytelling through the Tik Tok Application Affects Followers’ Behaviour Changes

Triwidyati

Pangastuti

2021

Jurnal Ekonomi & Bisnis JAGADITHA

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“…PDXs related primary cells were cultured in RPMI 1640 medium supplemented with 10% FBS or charcoal-stripped fetal bovine serum (FBS) (Invitrogen) (androgen-depleted medium) and 100 μg/ml penicillin-streptomycin-glutamine (Invitrogen) at 37 °C with 5% CO 2 . Cell authentication was performed using STR profiling as previously description [ 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

et al. 2020

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Background N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in mammalian cells. However, the disease relevant function of m6A on specific oncogenic long non-coding RNAs (ncRNAs) is not well understood. Methods We analyzed the m6A status using patients samples and bone metastatic PDXs. Through m6A high-throughput sequencing, we identified the m6A sites on NEAT1–1 in prostate bone metastatic PDXs. Mass spec assay showed interaction among NEAT1–1, CYCLINL1 and CDK19. RNA EMSA, RNA pull-down, mutagenesis, CLIP, western blot, ChIP and ChIRP assays were used to investigate the molecular mechanisms underlying the functions of m6A on NEAT1–1. Loss-of function and rescued experiments were executed to detect the biological roles of m6A on NEAT1–1 in the PDX cell phenotypes in vivo. Results In this study, we identified 4 credible m6A sites on long ncRNA NEAT1–1. High m6A level of NEAT1–1 was related to bone metastasis of prostate cancer and m6A level of NEAT1–1 was a powerful predictor of eventual death. Transcribed NEAT1–1 served as a bridge to facility the binding between CYCLINL1 and CDK19 and promoted the Pol II ser2 phosphorylation. Importantly, depletion of NEAT1–1or decreased m6A of NEAT1–1 impaired Pol II Ser-2p level in the promoter of RUNX2. Overexpression of NEAT1–1 induced cancer cell metastasis to lung and bone; xenograft growth and shortened the survival of mice, but NEAT1–1 with m6A site mutation failed to do these. Conclusion Collectively, the findings indicate that m6A on ncRNA NEAT1–1 takes critical role in regulating Pol II ser2 phosphorylation and may be novel specific target for bone metastasis cancer therapy and diagnosis. New complex CYCLINL1/CDK19/NEAT1–1 might provide new insight into the potential mechanism of the pathogenesis and development of bone metastatic prostate cancer.

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“…[ 1–7 ] With the development of nanotechnology, many NTAs with imaging capabilities including computed tomography (CT), magnetic resonance imaging (MRI), and photoacoustic (PA) imaging and therapeutic functions including photodynamic therapy (PDT), photothermal therapy (PTT), or chemodynamic therapy (CDT) have been extensively developed. [ 8–18 ] However, most of reported NTAs suffer from their poor tumor specificity and unsatisfactory therapeutic efficiency due to the severe background interference during metabolism caused by the “always on” model. [ 19–21 ] To solve this problem, in situ NTA synthesis strategy to activate pro‐NTAs (precursor of NTAs) into NTAs at desired locations has attracted increasing attention.…”

Section: Methodsmentioning

confidence: 99%

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

et al. 2020

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Nanotheranostic agents (NTAs) that integrate diagnostic capabilities and therapeutic functions have great potential for personalized medicine, yet poor tumor specificity severely restricts further clinical applications of NTAs. Here, a pro‐NTA (precursor of nanotheranostic agent) activation strategy is reported for in situ NTA synthesis at tumor tissues to enhance the specificity of tumor therapy. This pro‐NTA, also called PBAM, is composed of an MIL‐100 (Fe)‐coated Prussian blue (PB) analogue (K2Mn[Fe(CN)6]) with negligible absorption in the near‐infrared region and spatial confinement of Mn2+ ions. In a mildly acidic tumor microenvironment (TME), PBAM can be specifically activated to synthesize the photothermal agent PB nanoparticles, with release of free Mn2+ ions due to the internal fast ion exchange, resulting in the “ON” state of both T1‐weighted magnetic resonance imaging and photoacoustic signals. In addition, the combined Mn2+‐mediated chemodynamic therapy in the TME and PB‐mediated photothermal therapy guarantee a more efficient therapeutic performance compared to monotherapy. In vivo data further show that the pro‐NTA activation strategy could selectively brighten solid tumors and detect invisible lymph node metastases with high specificity.

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Enhancing Prostate‐Cancer‐Specific MRI by Genetic Amplified Nanoparticle Tumor Homing

Cited by 21 publications

References 38 publications

Storytelling through the Tik Tok Application Affects Followers’ Behaviour Changes

Storytelling through the Tik Tok Application Affects Followers’ Behaviour Changes

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

Tumor‐Microenvironment‐Triggered Ion Exchange of a Metal–Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

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