Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis

Fernandez-Carbonell, Cristina; Charvet, Leigh; Krupp, Lauren

doi:10.1007/s40272-021-00451-5

Cited by 7 publications

(5 citation statements)

References 133 publications

(165 reference statements)

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“…In particular, vitamin D integration in MS has been well studied. A vitamin D deficiency is associated with the progression of long-term disability, while the increase in its serum level reduced brain lesions and improved timed tandem walking [ 25 , 26 ], high levels of vitamin D, and a diet low in saturated fat are associated with lower relapse rates in pediatric-onset multiple sclerosis [ 27 ], with a higher physical and mental QOL [ 28 ]. The role of the vitamin B complex in MS is still debated [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

Pasquale¹,

Francesco²,

Shevchenko

et al. 2021

Medical Sciences

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Despite recent advances in immune-modulatory drugs, pharmacological therapies have been proven ineffective in severe presentations of multiple sclerosis (MS), including secondary progressive MS. At present, therapeutic interventions’ performance is primarily focused on ameliorating symptoms to improve the patient’s quality of life (QOL). Among complementary treatments, nutrition has been considered a decisive factor to control symptoms and enhance the wellness of MS patients. Although no special diets are associated with MS, the impact of diet and dietary supplements on the course of progressive forms of the disease has been studied during the last few years. Fatigue is among the most common and disabling symptoms reported by MS patients. Fatigue has been defined in the Multiple Sclerosis Council for Clinical Practice Guidelines (MSCCPG, 1998) as a “subjective lack of physical and/or mental energy that the individual perceives as an interference with habitual and desired activities”. This study aimed to compare the psychometric functioning of the “Fatigue Severity Scale” (FSS) and the “Modified Fatigue Impact Scale” (MFIS) in our sample of people with MS. Specifically, during chronic treatment, the change in these two parameters with two vitamin-rich dietary supplements (Citozym® and Ergozym®) was evaluated. The impact of these nutritional supplements revealed differences in antioxidant and anti-inflammatory parameters among the volunteers in the treatment group, with a subsequent improvement in fatigue. In conclusion, the results obtained have confirmed the effectiveness of complementary nutritional therapies, evaluated essentially based on hematological biomarkers, through which it is possible to act on disability to improve the QOL of MS patients.

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Section: Discussionmentioning

confidence: 99%

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

Pasquale¹,

Francesco²,

Shevchenko

et al. 2021

Medical Sciences

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“…Care models that advocate exercise, nutrition, healthy weight, avoidance of smoking or smoke exposure, and proper sleep have a meaningful contribution to the management of POMS patients. 54 Exercise interventions have the potential to reduce fatigue and depression in youth with POMS. 55…”

Section: New Horizons For Pomsmentioning

confidence: 99%

Pediatric multiple sclerosis: The 2022 ECTRIMS lecture

Banwell

2023

Mult Scler

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The 2022 ECTRIMS lecture focused on pediatric-onset multiple sclerosis (POMS), in recognition of the pivotal importance of prompt recognition and treatment of children and youth diagnosed with multiple sclerosis (MS), enabled over the past decade by the formal inclusion of pediatric patients in the McDonald diagnostic criteria. Epidemiologic, genetic and immunologic research has supported the concept that MS is a single disease across the age span and that clues to the inciting and early facets of MS pathobiology might be uniquely discerned through study of the youngest MS patients. Pediatric trials of pharmaceutical agents approved in adult-onset MS are emerging, although innovative study designs, alignment of regulatory agency requirements for trial design, family-centric models for study visits and emphasis on long-term safety and tolerability are essential. Evidence of safety and efficacy of key therapies is key if POMS patients are to be availed of the full armamentarium of MS therapeutic options. Finally, the rarity of POMS necessitates an international community effort to advance care and research. Such collaborations have been facilitated through the International Pediatric Multiple Sclerosis Group, Multiple Sclerosis International Federation, and by national multiple sclerosis societies. International efforts and priorities for the next decade will be highlighted.

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“…It is not clear whether the recently reported increased incidence may be real or more likely dependent on better diagnostic methods [ 2 , 153 , 154 , 155 , 156 ]. As outlined before, at any rate, data in POMS remain scarce mainly due to small sample size [ 1 , 157 ]. Despite POMS’s active inflammatory course, with frequent relapses/partial recovery episodes [ 158 , 159 , 160 ], presently available DMT may attain a discrete inflammation control [ 161 , 162 ], with a beneficial reduction of annualized relapse rates which may interfere with age specific cognitive impairment [ 160 ].…”

Section: Diet and Nutrition Related Issues In Pediatric-onset Msmentioning

confidence: 99%

Multiple Sclerosis—Related Dietary and Nutritional Issues: An Updated Scoping Review with a Focus on Pediatrics

Mandato,

Colucci,

Lanzillo

et al. 2023

Children

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Purpose. Lifestyle/dietetic habits play an important role in the development and progression of multiple sclerosis (MS) disease. Here, we examine the basic pathomechanisms underlying intestinal and brain barrier modifications in MS and consider diets and dietary supplementations proposed over time to complement pharmacological therapies for improving disease outcome both in adults and in children. Methods. Scoping literature search about evidence-based findings in MS-related gut-brain axis (GBA) pathophysiology and nutritional issues at all ages. Findings. Data show that (1) no universal best diet exists, (2) healthy/balanced diets are, however, necessary to safeguard the adequate intake of all essential nutrients, (3) diets with high intakes of fruits, vegetables, whole grains, and lean proteins that limit processed foods, sugar, and saturated fat appear beneficial for their antioxidant and anti-inflammatory properties and their ability to shape a gut microbiota that respects the gut and brain barriers, (4) obesity may trigger MS onset and/or its less favorable course, especially in pediatric-onset MS. Vitamin D and polyunsaturated fatty acids are the most studied supplements for reducing MS-associated inflammation. Conclusions. Pending results from other and/or newer approaches targeting the GBA (e.g., pre- and probiotics, engineered probiotics, fecal-microbiota transplantation), accurate counseling in choosing adequate diet and maintaining physical activity remains recommended for MS prevention and management both in adults and children.

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Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis

Cited by 7 publications

References 133 publications

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

Pediatric multiple sclerosis: The 2022 ECTRIMS lecture

Multiple Sclerosis—Related Dietary and Nutritional Issues: An Updated Scoping Review with a Focus on Pediatrics

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