Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

Abstract

Despite recent advances in immune-modulatory drugs, pharmacological therapies have been proven ineffective in severe presentations of multiple sclerosis (MS), including secondary progressive MS. At present, therapeutic interventions’ performance is primarily focused on ameliorating symptoms to improve the patient’s quality of life (QOL). Among complementary treatments, nutrition has been considered a decisive factor to control symptoms and enhance the wellness of MS patients. Although no special diets are associated with MS, the impact of diet and dietary supplements on the course of progressive forms of the disease has been studied during the last few years. Fatigue is among the most common and disabling symptoms reported by MS patients. Fatigue has been defined in the Multiple Sclerosis Council for Clinical Practice Guidelines (MSCCPG, 1998) as a “subjective lack of physical and/or mental energy that the individual perceives as an interference with habitual and desired activities”. This study aimed to compare the psychometric functioning of the “Fatigue Severity Scale” (FSS) and the “Modified Fatigue Impact Scale” (MFIS) in our sample of people with MS. Specifically, during chronic treatment, the change in these two parameters with two vitamin-rich dietary supplements (Citozym® and Ergozym®) was evaluated. The impact of these nutritional supplements revealed differences in antioxidant and anti-inflammatory parameters among the volunteers in the treatment group, with a subsequent improvement in fatigue. In conclusion, the results obtained have confirmed the effectiveness of complementary nutritional therapies, evaluated essentially based on hematological biomarkers, through which it is possible to act on disability to improve the QOL of MS patients.

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB, and Wnt/β-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome

“…There are now many studies showing that targeting redox pathways with selected antioxidants may improve chronic fatigue-like symptoms in animal models of CFS and in chronic fatigue comorbid with neuroinflammatory disease (24,26,80,81). In reserpine-induced zebrafish models of fibromyalgia (which is strongly associated with ME/CFS), treatment with hydroxytyrosol, a phenolic phytochemical that has antioxidant properties, regulates Wnt/β-catenin pathway activation and microglial activation in association with improving the behavioral deficits (82).…”

Association of Higher Mediterranean Diet Adherence With Lower Prevalence of Disability and Symptom Severity, Depression, Anxiety, Stress, Sleep Quality, Cognitive Impairment, and Physical Inactivity in Older Adults With Multiple Sclerosis

“…Despite the recent advances in immune-modulatory drugs, pharmacological therapies have been proven ineffective in severe presentations of MS. 72 Among complementary treatments, nutritional interventions have been considered a promising and decisive factor to control symptoms and enhance the wellness of peoples with MS. Several nutritional supplements revealed differences in antioxidant and anti-inflammatory parameters among patients, with a subsequent improvement in fatigue. 73 Moreover, several substantial studies have documented a systematically high prevalence of vitamin A, B12 and D3 deficiency amongst peoples with MS, which could be ameliorated by dietary supplements administration.…”

Therapeutic Potential of a Biodynamic Supplement on Skin Pressure Ulcers: A Clinical Study

“…Therefore, being able to reprogram the function of these enzymes could represent an attractive avenue for the treatment of bedsores. Citozym ® is a product that belongs to a new generation of nutritional supplements, defined as "Biodynamic", which can provide functional foods obtained from specific enzymatic conversions and therefore "nourish" the cells directly and quickly [11]. This experimental investigation aimed to use this nutritional supplement to verify its capacity as an authentic therapeutic target for the therapy of PU.…”