Enhancing Effect of High Fat Diet on 4‐Nitroquinoline 1‐Oxide‐induced Pulmonary Tumorigenesis in ICR Male Mice

Imaida, Katsumi; Sato, Hidetaka; Okamiya, Hideaki; Takahashi, Michihito; Hayashi, Yuzo

doi:10.1111/j.1349-7006.1989.tb01665.x

Cited by 15 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…experimental studies in rodents have shown that ω-3 unsaturated fatty acids may enhance the development of cancer in colon (29), breast (30) and liver (31). We previously noted the promotion of 4nQo-induced pulmonary tumorigenesis in male Icr mice due to a high-fat diet (21). the lack of any enhancing effect of a high concentration of corn oil in the diet in the present study is therefore noteworthy.…”

Section: Discussioncontrasting

confidence: 39%

See 1 more Smart Citation

Tumorigenesis of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice

Takeuchi

Saoo²,

Yamakawa³

et al. 2010

Oncology Letters

Self Cite

View full text Add to dashboard Cite

Abstract. It has been reported that 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx) induces liver tumors and to a lesser extent lung lesions, lymphomas and leukemias in cDF 1 mice. since a number of case control studies have pointed to a positive association between fat consumption and lung cancer, we examined the lung carcinogenic potential of MeIQx treatment concomitant with a high-fat diet using female A/J mice. groups 1 and 2 were fed a diet supplemented with MeIQx at a concentration of 600 ppm. groups 1 and 3 received a diet containing 20% corn oil and group 4 was fed the basal diet alone. After 1 week, 10 mice in each group were sacrificed for measurement of cytochrome P450 (cyP)1A2 mrnA in the liver and lung. the remaining mice were maintained on their respective diets until termination, 32 weeks after the initial MeIQx treatment, when lung proliferative lesions were analyzed. the incidences and multiplicities of hyperplasias and adenomas in MeIQx-treated groups (groups 1 and 2) were significantly higher than in the groups without MeIQx treatment, with a significant increase in the incidences and multiplicities of adenomas + carcinomas, as well as hyperplasia + adenomas + carcinomas (lung proliferative lesions). lung carcinomas were observed in 1 mouse in each of the MeIQx-treated groups.However, the high-fat diet (groups 1 and 3) did not affect the incidences or multiplicities of lung proliferative lesions. expression levels of cyP1A2 mrnA after MeIQx treatment significantly increased >3-fold in livers, but no significant change was noted in the lungs, where levels were very low at 1/210 and 1/923 the values for livers. In conclusion, following a 32-week period, we confirmed the lung tumorigenic potential of MeIQx which possibly occurs due to proximate carcinogens activated by cyP1A2 in the liver. However, we failed to detect any influence of a high-fat diet.

show abstract

Section: Discussioncontrasting

confidence: 39%

“…A high-fat diet was previously shown to enhance the 4-nitroquinoline 1-oxide (4nQo)-induction of lung tumorigenesis in mice (21). Female A/J mice which are highly susceptible to lung carcinogens were selected to investigate the relationship between the lung carcinogenic potential of MeIQx and a high-fat diet in a medium-term test.…”

Section: Introductionmentioning

confidence: 99%

Tumorigenesis of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice

Takeuchi

Saoo²,

Yamakawa³

et al. 2010

Oncology Letters

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the mean numbers of lung tumors/animal were significantly different between groups 1 and 2 sacrificed at weeks 15 and 25. This study demonstrated that dietary high fat clearly enhances the development of 4NQO-initiated mouse lung tumors 26 . Similar results were also published for benzo[a]pyreneinduced hamster respiratory tumor development 27 and Nnitrosobis(2-oxopropyl)amine-induced hamster lung tumorigenesis 28 .…”

Section: Effects Of Dietary Factors On Lung Carcinogenesismentioning

confidence: 51%

“…With regard to lung carcinogenesis, only a few promoters have been identified, such as bleomycin 19 , butylated hydroxytoluene 2 0 -2 2 glycerol 2 3 , 2 4 or iron administration 25 . We investigated the influence of dietary high fat diet on 4-nitroquinoline 1-oxide (4NQO)-induced lung tumorigenesis in the ICR mouse 26 . A total of 160, 6-week-old male ICR mice (Charles River Japan Inc., Atsugi) were divided into 4 equal groups: Groups 1 and 2 were given a single injection of 4NQO subcutaneously at a dose of 15 mg/kg body weight, and Groups 3 and 4 received a single injection of 10 ml/kg body weight of the oil mixture without 4NQO.…”

Section: Effects Of Dietary Factors On Lung Carcinogenesismentioning

confidence: 99%

Detection of Carcinogenic and Modifying Potentials by Test Compounds Using a Mouse Lung Carcinogenesis Bioassay

2007

Self Cite

View full text Add to dashboard Cite

Lung cancer is one of the most common cancers in the world, and the incidence of lung cancer is increasing. Therefore, it is particularly important to detect carcinogenic or tumor promoting substances of lung carcinogenesis in our environment, so that such harmful chemicals can be eliminated from our environment. Furthermore, detection of chemopreventive agents of lung carcinogenesis is also important to reduce our risk of lung cancer. It is necessary to establish reliable in vivo animal models of lung carcinogenesis for that purpose. The A/J mouse is a mouse strain sensitive to lung carcinogens, and also develops spontaneous lung tumors without any chemical treatment. In our department, we have demonstrated that a treatment of 4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone (NNK), a tobacco specific nitrosamine, or 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (MeIQx), a heterocyclic amine, induced lung tumors in the female A/J mouse in 16 and 32 weeks. The lung tumors developed in the A/J mouse are histopathologically classified as adenocarcinomas, adenomas, and alveolar cell hyperplasias. Some of these types of lung cancer are similar to those of human lung cancer. We also investigated the chemopreventive effects of bovine LF (bLF) on different phases of NNK-induced lung tumorigenesis in A/J mice. The A/J mouse is very useful mouse strain as a reliable in vivo model, which can be used for detecting chemopreventive agents of lung carcinogenesis. (J Toxicol Pathol 2007; 20: 117-123)

show abstract

“…experimental studies in rats have shown that fats containing ˆ-6 fatty acids (for example, corn oil) enhance, while ˆ-3 fatty acids (for example, fish oil and mustard oil) reduce, the development of chemically-induced colon tumors (23,24). Previously, we reported that a high fat diet (20% corn oil) enhanced 4-nitroquinoline 1-oxide (4nQo)-induced pulmonary tumorigenesis in male icr mice (25). Therefore, in the present study, female a/J mice, which are highly susceptible to lung carcinogens, were fed a diet supplemented with MeiQx and a high concentration of corn oil, to test for the development of lung tumors.…”

Section: Introductionmentioning

confidence: 99%

Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced lung tumorigenesis in female A/J mice

Matsuda

Takeuchi²,

Yokohira³

et al. 2009

Mol Med Rep

View full text Add to dashboard Cite

show abstract

Enhancing Effect of High Fat Diet on 4‐Nitroquinoline 1‐Oxide‐induced Pulmonary Tumorigenesis in ICR Male Mice

Cited by 15 publications

References 11 publications

Tumorigenesis of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice

Tumorigenesis of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice

Detection of Carcinogenic and Modifying Potentials by Test Compounds Using a Mouse Lung Carcinogenesis Bioassay

Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced lung tumorigenesis in female A/J mice

Contact Info

Product

Resources

About