Enhancing droplet transition capabilities using sloped microfluidic channel geometry for stable droplet operation

Wippold, Jose A; Huang, Can; Stratis‐Cullum, Dimitra N.; Han, Arum

doi:10.1007/s10544-019-0466-x

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…128 (i) Sloped microfluidic channels for applying lateral spatial shear stress gradients to cells. 129 (j and k) Microfluidic channels designed with gradual changes in height to enhance microdroplet: (j) stability, 130 and (k) manipulations (e.g., size-based sorting). 132 3.…”

Section: Master Mould Fabrication For Microreplication Via Direct Las...mentioning

confidence: 99%

Direct laser writing-enabled 3D printing strategies for microfluidic applications

Young,

Xu,

Sarker

et al. 2024

Lab Chip

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Section: Master Mould Fabrication For Microreplication Via Direct Las...mentioning

confidence: 99%

Direct laser writing-enabled 3D printing strategies for microfluidic applications

Young,

Xu,

Sarker

et al. 2024

Lab Chip

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“…Impedance sensing often requires shallow sensing channels with narrow electrode gaps [ 73 ], which might introduce unwanted channel fluidic resistances that hurdle microfluidic operation. This issue might be able to be resolved by fabricating microchannels with variable heights with an advanced photolithography method to only decrease the channel height at the detection region [ 38 , 74 ]. Additionally, to provide better impedance contrast to enhance detection, different frequencies might be required to fit application scenarios [ 8 , 64 ], and sometimes, low conductivity media are also essential to facilitate the detection by reducing the background signal from aqueous media [ 69 ].…”

Section: Detection Methodsmentioning

confidence: 99%

Droplet Detection and Sorting System in Microfluidics: A Review

Huang

Jiang

et al. 2022

Micromachines

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Since being invented, droplet microfluidic technologies have been proven to be perfect tools for high-throughput chemical and biological functional screening applications, and they have been heavily studied and improved through the past two decades. Each droplet can be used as one single bioreactor to compartmentalize a big material or biological population, so millions of droplets can be individually screened based on demand, while the sorting function could extract the droplets of interest to a separate pool from the main droplet library. In this paper, we reviewed droplet detection and active sorting methods that are currently still being widely used for high-through screening applications in microfluidic systems, including the latest updates regarding each technology. We analyze and summarize the merits and drawbacks of each presented technology and conclude, with our perspectives, on future direction of development.

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“…However, this technique exhibits a slower printing speed due to its tracing method and is very expensive [158]. Despite its shortcomings, 2PP has been applied to microfluidics [176,[179][180][181], with very few applications in droplet-based platforms [182,183]. Wippold et al fabricated a microfluidics master mold with channel dimensions in the z-direction as low as 15 µm using Nanoscribe Photonics Professional (2PP-based printer) [182].…”

Section: Slamentioning

confidence: 99%

“…Despite its shortcomings, 2PP has been applied to microfluidics [176,[179][180][181], with very few applications in droplet-based platforms [182,183]. Wippold et al fabricated a microfluidics master mold with channel dimensions in the z-direction as low as 15 µm using Nanoscribe Photonics Professional (2PP-based printer) [182]. They focused on using the 2PP technique for enhancing the droplet stability using a sloped geometry for microfluidic channels where the droplets gradually move from deep microchannels to shallower ones.…”

Section: Slamentioning

confidence: 99%

Recent Developments in 3D Printing of Droplet-Based Microfluidics

Aladese

Jeong

2021

BioChip J

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The advent of microfluidics, especially with the integration of droplet-based systems, has led to significant innovations and outstanding applications in many fields. While this field of study has grown increasingly over the years, the conventional method of fabricating these devices has discouraged their large-scale production, making their commercialization almost impossible. This is because traditional methods of producing droplet-based microfluidics are mostly time-consuming and labor-intensive and involve multiple processes. The emergence of 3D printing has found its application in microfluidics, providing an avenue for ease of fabrication with the aim of overcoming the limitations of conventional methods. While previous studies focused on studying the role of 3D printing in microfluidics, no study has categorically focused on the application of additive manufacturing to droplet-based microfluidics. This paper reviews the various 3D printing techniques associated with droplet-based microfluidics. Furthermore, we identify the salient features, limitations, and material properties of each printing technique while providing certain projections about their future application.

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Enhancing droplet transition capabilities using sloped microfluidic channel geometry for stable droplet operation

Cited by 9 publications

References 11 publications

Direct laser writing-enabled 3D printing strategies for microfluidic applications

Direct laser writing-enabled 3D printing strategies for microfluidic applications

Droplet Detection and Sorting System in Microfluidics: A Review

Recent Developments in 3D Printing of Droplet-Based Microfluidics

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