Enhancing blood donor skin disinfection using natural oils

Alabdullatif, Meshari; Boujezza, Imen; Mekni, Mohamed Amine; Taha, Mariam; Kumaran, Dilini; Yi, Qilong; Landoulsi, Ahmed; Ramírez‐Arcos, Sandra

doi:10.1111/trf.14298

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…They showed that in biofilm, CHD combined with eucalyptus oil demonstrated synergistic activity against the clinical isolate of Staphylococcus epidermidis, with an FICI value of 0.19. According to Alabdullatif et al [26] linalool significantly enhances anti-biofilm activity of CHD with isopropyl alcohol and can potentially be used to improve skin disinfection.…”

Section: Discussionmentioning

confidence: 99%

The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

et al. 2019

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In the post-antibiotic era the issue of bacterial resistance refers not only to antibiotics themselves but also to common antiseptics like octenidine dihydrochloride (OCT). This appears as an emerging challenge in terms of preventing staphylococcal infections, which are both potentially severe and easy to transfer horizontally. Essential oils have shown synergisms both with antibiotics and antiseptics. Therefore the aim of this study was to investigate the impact of lavender essential oil (LEO) on OCT efficiency towards methicillin-resistant S. aureus strains (MRSA). The LEO analyzed in this study increased the OCT’s susceptibility against MRSA strains. Subsequent FTIR analysis revealed cellular wall modifications in MRSA strain cultured in media supplemented with OCT or LEO/OCT. In conclusion, LEO appears to be a promising candidate for an efficient enhancer of conventional antiseptics.

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Section: Discussionmentioning

confidence: 99%

The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

et al. 2019

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“…In traditional medicine and in clinical practice, T. vulgaris is used, and T. vulgaris shows promising results on inflammatory skin disorders [ 115 ], scabies, herpes, wounds, alopecia, dental plaque [ 116 ], ringworm, and headaches [ 106 ]. Moreover, T. vulgaris showed a promising insecticidal effect on Culex pipiens , the vector for lymphatic filariasis [ 117 ], demonstrating an increased importance in many fields.…”

Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

244

143

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Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a reliable source of new therapy. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. The medicinal use of plants as analgesic or antinociceptive drugs in traditional therapy is estimated to be about 80% of the world population. The Lamiaceae family, one of the most important herbal families, incorporates a wide variety of plants with biological and medical applications. In this study, the analgesic activity, possible active compounds of Lamiaceae genus, and also the possible mechanism of actions of these plants are presented. The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.

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“…The presumptive drug target of MRSA biofilm is dehydroxysqualene synthase which produces staphyloxanthin, its main biofilm component [162, 163, 164, 53, 115]. Essential oils are also used to treat infections against gram negative bacteria relevant in veterinary in the Syn-NPs-CAAs format [5].…”

Section: Resultsmentioning

confidence: 99%

“…The presumptive drug target of MRSA biofilm is dehydroxysqualene synthase which produces staphyloxanthin, its main biofilm component [162,163,164,53,115].…”

Section: Inhibition Of Toxin Production and Antibiofilm Activitiesmentioning

confidence: 99%

Perspectives on the enhancement of commercially available antibiotics by natural products

Nitsch-Velasquez

Segura²,

Barrios

et al. 2022

Preprint

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Background: Opportunistic resistant bacteria are health and economically relevant in the health care systems and in industries worldwide, especially in the so-called resistant bacteria era (RBE). Enhancing the activity of commercially available antibiotics (CAAs) with di erent types of natural products (NPs) is a successful antimicrobial strategy, for instance the amoxicillin and clavulanate mixture. Objective: To nd research trends in this eld during 2015-2020 and to detect potential drug hits with potential to diversify formulations and materials design that can be useful to manage the RBE. Systematic review results: It yielded 190 reports of synergistic e ects of CAAs and NPs. The analyzed variables were: a) natural products origin: plant family, genera, secondary metabolite type; b) strains: +/- Gram, genera, most frequent species, application eld; and c) CAAs: family, most frequent CAAs. The families with potential to have more bioactive species were Apocynaceae, Rubiaceae, Euphorbiaceae (Isbio factor). Lonicera had the highest reports amount. Polyphenols and avonoids were the majority of pure NPs tested. Several potential drug hits for antibiotic activity enhancement at synergistic level were identi ed together with potential mechanisms of action: berberine (drug e ux inhibitor{DEI, bio lm inhibitor{BI), curcumin (BI), essential oils (BI), 3-o-metyl-butylgallato (inhibition of fatty acid saturation), among others. About the half of the tested strains were gram positive, being Methicillin Resistant Staphylococcus aureus (MRSA) the most frequently tested. Escherichia coli was the gram negative strain most frequently reported, including enterotoxigenic and extended spectrum beta-lactamases producers. The growth of other foodborne genera strains, such as Listeria and Salmonella, were also inhibited. Aminoglycosides were the family most reported, with gentamicin as the most commonly studied. Conclusions: NPs as either as plant extracts from a variety of families, or as puri ed compounds specially avonoids and polyphenols, have shown e ective results to enhance the antibiotic activity of CAAs against gram positive and negative strains relevant to HC and FI. Their mechanisms of action are starting to be determined, as the case EPIs and BIs. Further research is needed to achieve co-formulations and materials design useful for those elds, that can certainly be positively impacted by pursuing this strategy.

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Enhancing blood donor skin disinfection using natural oils

Abstract: The anti-biofilm activity of chlorhexidine-gluconate plus isopropyl alcohol can be greatly enhanced by L. multifida oil or linalool. Therefore, these components could potentially be used to improve blood donor skin disinfection.

Cited by 10 publications

References 34 publications

The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Perspectives on the enhancement of commercially available antibiotics by natural products

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