Enhancing antibiotic activity: a strategy to control Acinetobacter infections

Chusri, Sasitorn; Villanueva, Iván; Voravuthikunchai, Supayang Piyawan; Davies, Julian

doi:10.1093/jac/dkp381

Cited by 76 publications

(62 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Geraniol significantly increases the efficacy of beta-lactams, quinolones, and chloramphenicol [63]. It is observed that at 40 mM, ellagic and tannic acids enhanced the activity of novobiocin, coumermycin, clorobiocin, rifampicin and fusidic acid against A. baumannii [73].…”

Section: Interaction Between Herbal Drugs and Antibioticsmentioning

confidence: 99%

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Bhardwaj¹,

BR²,

DK³

2016

Pharm Anal Acta

View full text Add to dashboard Cite

show abstract

Section: Interaction Between Herbal Drugs and Antibioticsmentioning

confidence: 99%

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Bhardwaj¹,

BR²,

DK³

2016

Pharm Anal Acta

View full text Add to dashboard Cite

show abstract

“…Addressing the long-term challenge posed by antibiotic resistant pathogens will require therapeutic strategies 10 and compound development 46,47 that considers ways to manipulate and slow the evolution of resistance.…”

Section: Towards Therapies Informed By Evolutionmentioning

confidence: 99%

Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance

2013

View full text Add to dashboard Cite

The evolution of antibiotic resistance can now be rapidly tracked with high-throughput technologies for bacterial genotyping and phenotyping. Combined with new approaches to evolve resistance in the laboratory and to characterize clinically evolved resistant pathogens, these methods are revealing the molecular basis and rate of evolution of antibiotic resistance under treatment regimens of single drugs or drug combinations. In this Progress article, we review these new tools to study the evolution of antibiotic resistance, and discuss how the genomic and evolutionary insights they provide could transform the diagnosis, treatment and predictability of antibiotic resistance in bacterial infections.

show abstract

“…The medical literature reported that many phenolic compounds of plant extracts enhance the potential of synthetic antibiotics against A. baumannii in vitro (Miyasaki et al, 2013). For instance, activity of rifampicin, coumermycin, fusidic acid, novobiocin, and chlorobiocin was enhanced by tannic acid and ellagic acid against A. baumannii in vitro (Chusri et al, 2009). Even synergy was observed between topical mafenide and green tea polyphenol against multi-drug resistance Acinetobacter baumannii in-vitro (Osterburg et al, 2009), while no effect of synergy was noted between any antibiotics for Gram-negative bacteria and norwogonin.…”

Section: Plant Active Compounds Against Acinetobacter Baumanniimentioning

confidence: 99%

Antimicrobial active herbal compounds against Acinetobacter baumannii and other pathogens

2015

View full text Add to dashboard Cite

Bacterial pathogens cause a number of lethal diseases. Opportunistic bacterial pathogens grouped into ESKAPE pathogens that are linked to the high degree of morbidity, mortality and increased costs as described by Infectious Disease Society of America. Acinetobacter baumannii is one of the ESKAPE pathogens which cause respiratory infection, pneumonia and urinary tract infections. The prevalence of this pathogen increases gradually in the clinical setup where it can grow on artificial surfaces, utilize ethanol as a carbon source and resists desiccation. Carbapenems, a β-lactam, are the most commonly prescribed drugs against A. baumannii. The high level of acquired and intrinsic carbapenem resistance mechanisms acquired by these bacteria makes their eradication difficult. The pharmaceutical industry has no solution to this problem. Hence, it is an urgent requirement to find a suitable alternative to carbapenem, a commonly prescribed drug for Acinetobacter infection. In order to do this, here we have made an effort to review the active compounds of plants that have potent antibacterial activity against many bacteria including carbapenem resistant strain of A. baumannii. We have also briefly highlighted the separation and identification methods used for these active compounds. This review will help researchers involved in the screening of herbal active compounds that might act as a replacement for carbapenem.

show abstract

Enhancing antibiotic activity: a strategy to control Acinetobacter infections

Abstract: Susceptibility of MDR A. baumannii to a variety of antibiotics was enhanced in the presence of ellagic and tannic acids. The use of such plant compounds might provide effective treatments for resistant Gram-negative bacterial infections.

Cited by 76 publications

References 43 publications

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance

Antimicrobial active herbal compounds against Acinetobacter baumannii and other pathogens

Contact Info

Product

Resources

About