Enhancement Patterns of Hepatocellular Carcinoma After Transarterial Chemoembolization Using Drug-Eluting Beads on Arterial Phase CT Images: A Pilot Retrospective Study

Chung, Woo-Suk; Lee, Kwang-Hun; Park, Mi‐Suk; Lee, Yeo Jin; Kwon, Joon Ho; Baek, Seung-Min; Kim, Do Young

doi:10.2214/ajr.11.7563

Cited by 23 publications

(23 citation statements)

References 33 publications

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“…Especially, the treatment response to DC Beads TACE can be evaluated more definitely than can that to cTACE, in which incomplete lipiodol uptake causes difficulty with evaluating the treatment response (Figure 2)[37]. …”

Section: Evaluating the Treatment Response To DC Beads Tacementioning

confidence: 99%

“…Chung et al[37] reported that the enhancement patterns of HCC after TACE used with beads could be useful for determining the prognosis. They analyzed images of the arterial phase of dynamic liver CT 1 mo after TACE with beads and categorized the enhancement patterns as no enhancement, peripheral ring enhancement, or peripheral nodule-like enhancement.…”

Section: Evaluating the Treatment Response To DC Beads Tacementioning

confidence: 99%

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Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma

Nam¹,

Jang²,

Song³

2016

WJG

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Transarterial chemoembolization (TACE) is a widely used standard treatment for patients with hepatocellular carcinoma (HCC) who are not suitable candidates for curative treatments. The rationale for TACE is that intra-arterial chemotherapy using lipiodol and chemotherapeutic agents, followed by selective vascular embolization, results in a strong cytotoxic effect as well as ischemia (conventional TACE). Recently, drug-eluting beads (DC Beads®) have been developed for transcatheter treatment of HCC to deliver higher doses of the chemotherapeutic agent and to prolong contact time with the tumor. DC Beads® can actively sequester doxorubicin hydrochloride from solution and release it in a controlled sustained fashion. Treatment with DC Beads® substantially reduced the amount of chemotherapeutic agent that reached the systemic circulation compared with conventional, lipiodol-based regimens, significantly reducing drug-related adverse events. In this article, we describe the treatment response, survival, and safety of TACE used with drug-eluting beads for the treatment of HCC and discuss future therapeutic possibilities.

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Section: Evaluating the Treatment Response To DC Beads Tacementioning

confidence: 99%

Section: Evaluating the Treatment Response To DC Beads Tacementioning

confidence: 99%

Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma

Nam¹,

Jang²,

Song³

2016

WJG

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“…However, even if arterial enhancement were to be observed with such an agent, the finding might not be confused with a pseudolesion, because the area would not exhibit washout in the delayed phase, unlike our results with gadoxetate disodium. Using drugeluting beads observed on arterial phase CT scans obtained within 1 month of TACE, Chung et al [13] found peripheral ring enhancement of HCC treated with TACE; 83% of the tumors turned out to be nonprogressive, and the authors ascribed this finding to nontumorous granuloinflammatory tissue resulting from TACE. This peripheral ring enhancement appears similar to the ringlike shape of the early pseudolesions in our study, although the latter seem somewhat thicker or larger than the former.…”

Section: Mri Of Hepatic Pseudolesionsmentioning

confidence: 99%

Pseudolesion of the Liver on Gadoxetate Disodium-Enhanced MR Images Obtained After Transarterial Chemoembolization for Hepatocellular Carcinoma: Clinicoradiologic Correlation

Shinagawa

Sakamoto²,

Fujimitsu³

et al. 2012

American Journal of Roentgenology

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“…Some authors classify crescent or incomplete ring enhancement as nodular enhancement (36). Necrotic tissue has no contrast media uptake, enhancement being observed in residual tumor tissue ( figure 3a).…”

Section: Areas Of Nodular or Crescent-shaped Enhancement In Connectiomentioning

confidence: 99%

Tumor response criteria for hepatocellular carcinoma treated by transarterial chemoembolization - a radiologist's point-of-view

Scheau¹,

Scheau²,

Dumitru³

et al. 2015

JTMR

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Hepatocellular carcinoma is a common malignancy which, in specific stages, benefits from transarterial chemoembolization. The survival of treated patients depends on the accurate interpretation of follow-up studies after the procedure, with focus on the early detection of residual tumor or tumor recurrence. Dynamical contrast enhanced CT and MRI are sensitive methods in evaluating tumor response, although diffusion weighted imaging and other new modalities can improve the diagnostic role of these tests. A strong knowledge of common and rare imaging signs of neoplastic tissue in a chemoembolized nodule can lead to a prompt and effective complementary treatment. Some lesions related to the endovascular intervention mimic tumor behavior and should always be sought and correctly identified, in order to avoid unnecessary treatment and impacts in the patient's quality of life.

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Enhancement Patterns of Hepatocellular Carcinoma After Transarterial Chemoembolization Using Drug-Eluting Beads on Arterial Phase CT Images: A Pilot Retrospective Study

Cited by 23 publications

References 33 publications

Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma

Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma

Pseudolesion of the Liver on Gadoxetate Disodium-Enhanced MR Images Obtained After Transarterial Chemoembolization for Hepatocellular Carcinoma: Clinicoradiologic Correlation

Tumor response criteria for hepatocellular carcinoma treated by transarterial chemoembolization - a radiologist's point-of-view

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