Enhancement of the release of azelaic acid through the synthetic membranes by inclusion complex formation with hydroxypropyl-β-cyclodextrin

Preparation and <i>in Vitro</i>, <i>in Vivo</i> Characterization of Elastic Liposomes Encapsulating Cyclodextrin-Colchicine Complexes for Topical Delivery of Colchicine

“…The tissue was further homogenized with 50％ ethanol (10 ml) and left at room temperature for 24 h. After shaking for 5 min and centrifugation for 5 min at 3000 rpm, the colchicine content in the upper phase was determined. 14,15) Vesicle-Skin Interaction Study Scanning Electron Microscopy Wistar rats weighing 150 200 g were divided into 4 groups each comprising 3 rats. Theˆrst group served as control and received topical application of drug solution (1.0 mg/ml) prepared in PBS pH 6.4.…”

Recent Advances in Drug Delivery Systems

“…Three types of cyclodextrins are found in the nature named α (6 units), β (7 units) and γ-cyclodextrins (8 units). β-Cyclodextrin is ideal for drug delivery due to the cavity size, efficiency drug complexation and loading, availability and relatively low cost [41,48]. They can prevent the drug degradation, improve the drug stability and solubility resulting on an higher bioavailability [4,48].…”

“…β-Cyclodextrin is ideal for drug delivery due to the cavity size, efficiency drug complexation and loading, availability and relatively low cost [41,48]. They can prevent the drug degradation, improve the drug stability and solubility resulting on an higher bioavailability [4,48]. An example of cyclodextrins in drug delivery system is the derivate 2-hydroxylpropyl (HPβCD) which is a powerful solubilizer and has a hydrophilic outside and hydrophobic inside [48].…”

“…They can prevent the drug degradation, improve the drug stability and solubility resulting on an higher bioavailability [4,48]. An example of cyclodextrins in drug delivery system is the derivate 2-hydroxylpropyl (HPβCD) which is a powerful solubilizer and has a hydrophilic outside and hydrophobic inside [48]. For absorption in the GI tract, the complexes must contact with the surface thus promoting dissociation and drug permeation across the membrane [41].…”

In Situ Intestinal Absorption Behaviors of Tanshinone IIA from Its Inclusion Complex with Hydroxypropyl-.BETA.-cyclodextrin

“…The cannula was then connected to two plastic tubes that were connected to a constant-flow pump (HL-2, XiangShan Lid., China). [17][18][19] As soon as the experiment began, the perfused intestinal segment was repositioned in the abdominal cavity, unimpeded axial flow was maintained, and the abdominal incision closed with wound clips. The recirculation fluid flowed into the segment at a rate of 1.0 ml · min…”