Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents

Adams, G.E.; Stratford, Ian J.; Godden, John O.; Howells, N.

doi:10.1016/0360-3016(89)90268-x

Cited by 15 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can also lead to a decrease in tumour pH, consequently increasing the anti-tumour effect of hyperthermia 3 and various chemotherapeutic agents, such as alkylating agents like melphalan. 4,5 . A decrease in tumour blood flow may also increase the effectiveness of other chemotherapeutic agents simply by increasing drug exposure time as a result of trapping the drugs in the tumour.…”

Section: Introductionmentioning

confidence: 99%

Localizedin vivo1H NMR spectroscopy of murine tumours: effect of blood flow reduction

et al. 1999

View full text Add to dashboard Cite

Single voxel 1H localized spectroscopy (PRESS at 300 MHz) was used to monitor physiological and biochemical changes induced by hydralazine (5 mg/kg, i.p.) in murine C3H mammary tumours. In addition to a significant increase (by 52%, maximal at 30 min) in the intensity of the 1.32 ppm signal (predominantly from lactate, consistent with a selective reduction in tumour blood supply by hydralazine), downfield shifts in the resonance frequencies of 1H signals were observed. In particular, the signal initially at 3.24 ppm (total choline, tCho) shifted by 0.050 ppm (maximal at 13 min), whereas water shifted by 0.086 ppm. Lactate intensity and water and tCho resonance frequencies returned to control values at approximately 100 min after treatment. No significant changes in the resonance frequencies of water or tCho were observed over this time period in the tumours of mice given saline. In vitro studies showed that, while the resonance frequency of water was temperature dependent, the main components of the tCho signal (choline, phosphorylcholine and glycerophosphorylcholine) were more than 30‐fold less sensitive to temperature. It was concluded that the shift in the water resonance frequency was due to the combined effects of tumour temperature reduction and a paramagnetic shift from increased deoxyhaemoglobin levels, whereas the tCho signal was only affected by the paramagnetic shifts. Copyright © 1999 John Wiley & Sons, Ltd.

show abstract

Section: Introductionmentioning

confidence: 99%

Localizedin vivo1H NMR spectroscopy of murine tumours: effect of blood flow reduction

et al. 1999

View full text Add to dashboard Cite

show abstract

Spatial heterogeneity of the metabolic response of RIF‐1 tumors to a vasoactive agent evaluated in vivo by one‐dimensional ³¹P chemical‐shift imaging

Bhujwalla¹,

Blackband²,

Wehrle³

et al. 1992

Magnetic Resonance in Med

View full text Add to dashboard Cite

Localized 31P NMR spectroscopy was used to evaluate the spatial heterogeneity of the metabolic response of RIF-1 tumors to hydralazine. Volume localized 31P spectra were obtained from subcutaneous RIF-1 tumors using one-dimensional chemical-shift imaging, before and 20 min after treatment with 5 mg/kg hydralazine, administered intravenously. Following treatment all of the tumors showed an overall decrease in the ratio of nucleoside triphosphate (NTP) to inorganic phosphate (Pi) and a decrease in pH. However, spatial localization revealed that the reduction in NTP/Pi was not uniform within some tumors. This was partly due to regional differences in the levels of metabolites existing before treatment. Normal tissue adjacent to the tumor did not show a significant decrease in high-energy metabolites or pH.

show abstract

Hypoxia in Tumours: Its Relevance, Identification, and Modification

Horsman

1993

Medical Radiology

View full text Add to dashboard Cite

Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents

Cited by 15 publications

References 8 publications

Localizedin vivo1H NMR spectroscopy of murine tumours: effect of blood flow reduction

Localizedin vivo1H NMR spectroscopy of murine tumours: effect of blood flow reduction

Spatial heterogeneity of the metabolic response of RIF‐1 tumors to a vasoactive agent evaluated in vivo by one‐dimensional ³¹P chemical‐shift imaging

Hypoxia in Tumours: Its Relevance, Identification, and Modification

Contact Info

Product

Resources

About

Enhancement of the anti-tumor effect of melphalan in experimental mice by some vaso-active agents

Cited by 15 publications

References 8 publications

Localizedin vivo1H NMR spectroscopy of murine tumours: effect of blood flow reduction

Localizedin vivo1H NMR spectroscopy of murine tumours: effect of blood flow reduction

Spatial heterogeneity of the metabolic response of RIF‐1 tumors to a vasoactive agent evaluated in vivo by one‐dimensional 31P chemical‐shift imaging

Hypoxia in Tumours: Its Relevance, Identification, and Modification

Contact Info

Product

Resources

About

Spatial heterogeneity of the metabolic response of RIF‐1 tumors to a vasoactive agent evaluated in vivo by one‐dimensional ³¹P chemical‐shift imaging