Enhancement of the Anaphylactoid Reaction in Rats by Salicylates

Abstract

Low doses of sodium or copper salicylate, administered at the same time as agents producing the anaphylactoid reaction in rats, significantly enhanced the onset, height and duration of the responses. The enhancement occurred after intraperitoneal or local administration. Enhanced transport of the high molecular weight agents into the bloodstream is suggested. However, the salicylates did not enhance histamine release from isolated peritoneal mast cells of rats induced by dextran and phosphatidyl serine.

Antagonistic Analogs of Luteinizing Hormone-Releasing Hormone Are Mast Cell Secretagogues

“…Histamine is a mediator of the edematous reactions induced in rats by dextran and 48/80 [20,21] and skin lesions in duced by intradermal injection of mast cell secretagogues [22,23]. However, serotonin is also involved in these reactions [21] and can be preferentially released from mast cells [24], Although all antagonists caused mast cell histamine release in vitro, and while an tagonists I and III did so in vivo, it may be that the antagonists release other mast cell mediators which are important in these reactions.…”

Enhancement of the Anaphylactoid Reaction in Rats by Phenylalanine Enamine

“…The enhancing effect of PAE on the anaphylactoid reaction in rats resembles, in many ways, those of in sulin [1] and salicylate [3]. In all cases, the reaction is more intense at all stages.…”

“…Increasing the dose of PAE to 80 or 160 mg kg"1 resulted in the enhancement being con siderably reduced or even annulled ( fig. 2), just as it was with high doses of salicylates [3].When the drugs were administered locally into rat paws, low doses (10-20 ug) of PAE potentiated the dextran response (100 /¿g) but higher doses (80-100 ug) were without effect ( fig. 3).…”

“…The enhancement occurred after intraperitoneal or local administration. The enamine did not modify the histamine or 5-hydroxytryptamine re sponses in rat paws, so its effect on dextran may be due to modification of the release mechanism of the two amines from tissue mast cells.Recently, we have shown [3] that sodium salicylate enhanced the dextran anaphylactoid response in rats when it was administered with the dextran. This re port followed the finding [2] that salicylates are effec tive adjuvants for the rectal absorption of insulin (a large molecular weight polypeptide) and heparin (a mucopolysaccharide), two compounds which nor mally are either degraded or poorly absorbed after or al administration.…”

Heparin and the Dextran Anaphylactoid Reaction in Rats

“…Recently, we have shown [4] that sodium salicylate enhances the dextran anaphylactoid response in rats administered with the dextran. This followed the re port [3] that salicylates are effective adjuvants for the rectal absorption of insulin (a polypeptide) and he parin (a mucopolysaccharide), compounds which normally are either degraded or poorly absorbed after oral administration.…”