Heparin and the Dextran Anaphylactoid Reaction in Rats

West, G. B.

doi:10.1159/000233350

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, at the highest injected doses, an increased accumulation was observed in some rats in lymph nodes draining extremities (see Figure ). This is most likely due to the paw edema which occurs in some rats after injection of large amounts of dextran-based preparations . Dextran sensitivity, however, is not the underlying mechanism of the lymphatic uptake of polyglucose-modified nanoparticles, since the uptake of dextran B-512 preparations in lymph nodes was also observed in rats that are not dextran-sensitive, as well as in mice, rabbits, and other animals and humans.…”

Section: Resultsmentioning

confidence: 99%

A Systemic Route for Drug Loading to Lymphatic Phagocytes

et al. 2005

View full text Add to dashboard Cite

Lymph nodes are primary germination and proliferation sites for many types of pathogens. Maintaining therapeutic levels of appropriate chemotherapeutic agents in the lymph node tissue is critical for the treatment of both infection and cancer. This study was intended to develop a systemic route for loading lymph node phagocytes with drugs, using a lymph node specific nanocarrier. The latter is assembled as a 10-15 nm particle with a drug-carrying core and a phagocyte-homing poly(1→6)-α-D-glucose based interface. Biokinetics and microdistribution of the model carrier were investigated in vivo. Nanocarrier accumulation in lymph nodes reached 30-35% dose/g in central lymph nodes, with deposition in various phagocytic cell populations. The latter included cells harboring inhaled microparticles translocated to lymph nodes from the lungs. In view of the nanocarrier ability to transport and release significant amounts of various drug substances, the data suggests feasibility of systemic drug loading to lymphatic phagocytes and, through drug release, to the neighboring cells.

show abstract

Section: Resultsmentioning

confidence: 99%

A Systemic Route for Drug Loading to Lymphatic Phagocytes

et al. 2005

View full text Add to dashboard Cite

show abstract

Antishock effects of corticosterone on dextran-induced shock in rats

Kogure¹,

Ishizaki²,

Nemoto³

et al. 1986

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

To study the effects of glucocorticoid on the shock state, dextran-induced shock in rats was used as an experimental model system. The rats were divided into three groups, viz., control (group A), adrenalectomized (group B), and adrenalectomized corticosterone supplemented (2 mg/rat for 4 days; group C), and 5% dextran solution was given intravenously to each rat. In group B, remarkable increases in the histamine levels in both plasma and the paw cutaneous tissue, hemoconcentration, and intractable hypotension were observed. Most rats in group B died during the shock experiment without showing any recovery when the cannulas were inserted into the left carotid artery for the measurement of blood pressure. But in group C, most rats eventually survived and recovered to a normal state within 2 h, so that corticosterone clearly ameliorated the shock state of adrenalectomized rats by dextran administration. These results suggested that the ameliorating effects of corticosterone in the dextran-induced shock states are due to the acceleration of the rate of clearance of circulating chemical mediators that are represented by histamine and are due to the alteration of overall responsiveness of the animals to a complex array of factors that threaten the status of the animals, as represented by the amelioration of the vascular activity.

show abstract

Heparin and the Dextran Anaphylactoid Reaction in Rats

Cited by 2 publications

References 4 publications

A Systemic Route for Drug Loading to Lymphatic Phagocytes

A Systemic Route for Drug Loading to Lymphatic Phagocytes

Antishock effects of corticosterone on dextran-induced shock in rats

Contact Info

Product

Resources

About