Enhancement of Splenic Glucose Metabolism During Acute Malarial Infection: Correlation of Findings of FDG-Pet Imaging With Pathological Changes in a Primate Model of Severe Human Malaria

Kawai, Shinya; Ikeda, Eiji; Sugiyama, Munehiro; Matsumoto, Jun; Higuchi, Tetsuya; Zhang, Hong; Khan, Nasim A.; Tomiyoshi, Katsumi; Inoue, Tomio; Yamaguchi, Hideyo; Katakura, Ken; Endo, Keigo; Matsuda, Hajime; Suzuki, Mamoru

doi:10.4269/ajtmh.2006.74.353

Cited by 24 publications

(17 citation statements)

References 25 publications

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“…Kawai et al [40] reported that there is diffusely increased splenic uptake on FDG-PET in a primate model with acute malarial infection, indicating marked enhancement of glucose metabolism. Increase in splenic uptake may reflect the activation of B-lymphocytes and splenic clearance system against blood-stage malarial parasites [41].…”

Section: Splenic Uptake In Other Benign Diseasementioning

confidence: 98%

Clinical significance of diffusely increased splenic uptake on FDG-PET

Liu

2009

Nuclear Medicine Communications

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Diffusely increased uptake is more commonly observed than focal uptake in the spleen on a whole-body [F] fluorodeoxyglucose-positron emission tomography/computed tomography. The significance of diffusely increased splenic uptake varies in different clinical settings. On a pre-therapeutic scan for lymphoma, splenic uptake, greater than hepatic uptake, is a relative reliable indication of lymphomatous involvement of the spleen, unless the patient has a history of recent cytokine administration. In HIV infection, increased splenic uptake is usually noted in the early stage of the disease, which could reflect massive stimulation of B-cells in the spleen by nonreplicating antigenic material. Diffusely increased splenic uptake may also be present in sarcoidosis, malaria, and many inflammatory or hematopoietic diseases. Therapeutic-related reactive splenic uptake concurrent with bone marrow uptake is often secondary to administration of granulocyte colony-stimulating factor for myelosuppression or high-dose interferon-alpha-2b adjuvant therapy for melanoma.

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Section: Splenic Uptake In Other Benign Diseasementioning

confidence: 98%

Clinical significance of diffusely increased splenic uptake on FDG-PET

Liu

2009

Nuclear Medicine Communications

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“…The splenic lesions were considered similar to those noted in humans infected with acute P. falciparum infections. 55 Reproductive System. Studies of placental pathology in the rhesus macaque model were conducted at Tulane University using primiparous and multiparous macaques.…”

Section: Histopathology and Immunohistochemistrymentioning

confidence: 99%

A Review of Plasmodium coatneyi–Macaque Models of Severe Malaria

et al. 2015

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Malaria remains one of the most significant public health concerns in the world today. Approximately half the human population is at risk for infection, with children and pregnant women being most vulnerable. More than 90% of the total human malaria burden, which numbers in excess of 200 million annually, is due to Plasmodium falciparum. Lack of an effective vaccine and a dwindling stockpile of antimalarial drugs due to increased plasmodial resistance underscore the critical need for valid animal models. Plasmodium coatneyi was described in Southeast Asia 50 years ago. This plasmodium of nonhuman primates has been used sporadically as a model for severe malaria, as it mimics many of the pathophysiologic features of human disease. This review covers the reported macroscopic, microscopic, ultrastructural, and molecular pathology of P. coatneyi infection in macaques, specifically focusing on the rhesus macaque, as well as describing the critical needs still outstanding in the validation of this crucial model of human disease.

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“…The reported cases with diffuse increased splenic FDG uptake on F-18 FDG PET/CT images include lymphoma, HIV infection, hematopoietic cytokines, sarcoidosis, malaria, extramedullary granulopoiesis, congestive splenomegaly, toxoplasmosis, infectious mononucleosis, varicella infection, myelofibrosis, b-thalassemia, and granulomatous angitis [6][7][8][9][10][11][12][13]. Also, diffuse increased splenic FDG uptake is sometimes observed on F-18 FDG PET/CT but its clinical significance is discussed sparsely in the literature.…”

Section: Introductionmentioning

confidence: 97%