Enhancement of solubility and dissolution rate of atorvastatin calcium by co-crystallization

Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer

“…The intermolecular interactions between the drug and the coformer in the new crystal lattice form different packing arrangements that trigger a change in physicochemical properties [10]. It is a potential method to improve the physicochemical properties of a drug in solubility [11][12][13], dissolution rate [14], stability [15][16], bioavailability [17], compressibility and hygroscopicity [18].…”

Experimental design approach for development of cocrystals and immediate release cocrystal tablet of atorvastatin calcium for enhancement of solubility and dissolution

“…1.9 fold increase in solubility (Figure 2). This can be attributed to the fact that formation of cocrystal, changes the crystal packing, resulting in reduced crystal energy/or increased solvent affinity [18].Also in solvent drop grinding method small amount of solvent is used, which acts as a catalyst in co-crystal formation. Moreover, it is one of the most cost-effective method in comparison to other methods, as it uses very less solvent and thus is more environment friendly than the solution based methods [44].…”

“…The augmentation in diffusion rate can be attributed to the reduced energy of the crystal lattice/ or change in the solvent affinity. Conversion of AVA into AVA cocrystal changes the crystal morphology which forms a new surface thus increases its dissolution and diffusion rate [18].…”

Enhancement of Glimepiride Bioavailability by Co-Crystallization Technique

“…Recently, several formulation techniques have been designed to overcome these problems including micronization (Ning et al, 2011), nanosuspension (Rahim et al, 2019), solid dispersion (Chaudhari et al, 2012), self-emulsifying system (Ahmed et al, 2014) , complexation with cyclodextrins (Ammar et al, 2006) and formation of co-crystal which is considered as one of the most promising approaches used to enhance the dissolution rate and eventually oral bioavailability of the poorly water soluble drugs. Cocrystal is defined as a non-single component system formed of various components that are solid under ambient conditions and attached with non-covalent bonds such as hydrogen bonds and van der Waals bonds (Wicaksono et al, 2017). Pharmaceutical cocrystals improve the physical properties of drugs such as solubility, wettability and compaction behaviors of the drug without affecting pharmacological nature of the drug (Ganesh et al, 2015).…”