Enhancement of single-walled carbon nanotube accumulation in glioma cells exposed to low-strength electric field: Promising approach in cancer nanotherapy

Golubewa, Lena; Kulahava, Tatsiana; Kunitskaya, Y. N.; Булай, П. М.; Шуба, М. В.; Karpicz, Renata

doi:10.1016/j.bbrc.2020.06.100

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Several works describe the use of CNTs as drug delivery systems, attributed to their capacity to improve efficacy and specificity of loaded drugs while reducing the undesirable effects. According to Golubewa et al (2020) [6], the use of electrical pulses promoted the accumulation of DNA-coated CNTs in the cytoplasm of glioma cells favored by the enhanced permeability and retention (EPR) effect. Other authors suggested the use of laser-mediated ablation of cancer cells marked with biofunctionalized CNTs, which caused necrosis of individual cancer cells and/or induced cell damage through nuclear fragmentation and organelles disintegration [7].…”

Section: Introductionmentioning

confidence: 99%

Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts

Neto

Lima

Morais

et al. 2021

Toxics

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Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose–effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.

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Section: Introductionmentioning

confidence: 99%

Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts

Neto

Lima

Morais

et al. 2021

Toxics

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“… 154 The low-frequency and low-strength electric field stimulation of glioma cells exposed to SWCNTs could lead to enhanced CNTs accumulation inside the cells. 154 In another study, the coupled SWCNTs with hyaluronic acid and chlorin e6 were explored against colon cancer using photodynamic therapy. 155 The nanosystem improved the efficacy of photodynamic therapy and triggered the death in colon cancerous cells.…”

Section: Carbon-based Nanomaterials With Biomedical Potentialsmentioning

confidence: 99%

“…146 The treated C6 glioma cells with DNA wrapped SWCNTs (5 mg mL À1 ) were exposed to bi-phasic electric pulses (6.6 V m À1 , 200 Hz, pulse duration 1 ms). 154 The low-frequency and lowstrength electric field stimulation of glioma cells exposed to SWCNTs could lead to enhanced CNTs accumulation inside the cells. 154 In another study, the coupled SWCNTs with hyaluronic acid and chlorin e6 were explored against colon cancer using photodynamic therapy.…”

Section: Review Materials Advancesmentioning

confidence: 99%

Eco-friendly synthesis of carbon nanotubes and their cancer theranostic applications

et al. 2022

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“…This facilitated the magnificent amplification of SWCNTs within the cells. Excitingly, it allowed the very minimal usage of drug application via carbon-based nanomaterials and enhanced the endocytosis of CNTs into the glioma [59].…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications

Lakshmi

Kim

2022

IJMS

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Brain tumors such as glioblastoma are typically associated with an unstoppable cell proliferation with aggressive infiltration behavior and a shortened life span. Though treatment options such as chemotherapy and radiotherapy are available in combating glioblastoma, satisfactory therapeutics are still not available due to the high impermeability of the blood–brain barrier. To address these concerns, recently, multifarious theranostics based on nanotechnology have been developed, which can deal with diagnosis and therapy together. The multifunctional nanomaterials find a strategic path against glioblastoma by adjoining novel thermal and magnetic therapy approaches. Their convenient combination of specific features such as real-time tracking, in-depth tissue penetration, drug-loading capacity, and contrasting performance is of great demand in the clinical investigation of glioblastoma. The potential benefits of nanomaterials including specificity, surface tunability, biodegradability, non-toxicity, ligand functionalization, and near-infrared (NIR) and photoacoustic (PA) imaging are sufficient in developing effective theranostics. This review discusses the recent developments in nanotechnology toward the diagnosis, drug delivery, and therapy regarding glioblastoma.

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Enhancement of single-walled carbon nanotube accumulation in glioma cells exposed to low-strength electric field: Promising approach in cancer nanotherapy

Cited by 6 publications

References 19 publications

Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts

Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts

Eco-friendly synthesis of carbon nanotubes and their cancer theranostic applications

Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications

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