Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy

Rahman, Wan Nordiana; Bishara, Nour; Ackerly, Trevor; He, Cheng Fa; Jackson, Price; Wong, Christopher J.; Davidson, Rob; Geso, Moshi

doi:10.1016/j.nano.2009.01.014

Cited by 324 publications

(284 citation statements)

References 21 publications

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“…Rahman et al [24] showed that millimolar concentrations of 1.9 nm gold particles decreased cell viability by 30% in bovine aortic endothelial cells. Patra and colleagues [40] demonstrated cell specific induction of apoptosis using multiple endpoints including poly(ADP-ribose) polymerase (PARP) cleavage and uptake of propidium iodide in baby hamster kidney and human hepatocellular carcinoma cells treated with 30-120 nm particles.…”

Section: Demonstrated 14 Nm Triphenyl Monosulfonate (Tppms)mentioning

confidence: 99%

“…Gold nanoparticles have been shown as potential radiation enhancing agents for the treatment of cancer [21][22][23][24][25]. This was first demonstrated by Hainfeld et al [21] who obtained dose enhancement ratios of at least 2, but potentially as high as 6 using 1.9 nm particles at a gold concentration of 7 mg g −1 when administered by intravenous injection to tumourbearing mice irradiated with 250 kVp x-rays.…”

Section: Introductionmentioning

confidence: 96%

“…Using the same size of particle, Rahman et al [24] demonstrated a peak radiation enhancement factor of 25 fold for kilovoltage x-rays at a 1 mM nanoparticle concentration in bovine endothelial cells irradiated with kilovoltage x-rays or megavoltage electrons. The effect of different sized nanoparticles (14-74 nm) was recently shown [25] with 50 nm particles showing the highest enhancement factor of 1.66 when irradiated with 6 MVp photons.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy

Butterworth¹,

Coulter²,

Jain³

et al. 2010

Nanotechnology

208

160

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High atomic number (Z) materials such as gold preferentially absorb kilovoltage x-rays compared to soft tissue and may be used to achieve local dose enhancement in tumours during treatment with ionizing radiation. Gold nanoparticles have been demonstrated as radiation dose enhancing agents in vivo and in vitro. In the present study, we used multiple endpoints to characterize the cellular cytotoxic response of a range of cell lines to 1.9 nm gold particles and measured dose modifying effects following transient exposure at low concentrations. Gold nanoparticles caused significant levels of cell type specific cytotoxicity, apoptosis and increased oxidative stress. When used as dose modifying agents, dose enhancement factors varied between the cell lines investigated with the highest enhancement being 1.9 in AGO-1522B cells at a nanoparticle concentration of 100 μg ml −1 . This study shows exposure to 1.9 nm gold particles to induce a range of cell line specific responses including decreased clonogenic survival, increased apoptosis and induction of DNA damage which may be mediated through the production of reactive oxygen species. This is the first study involving 1.9 nm nanometre sized particles to report multiple cellular responses which impact on the radiation dose modifying effect. The findings highlight the need for extensive characterization of responses to gold nanoparticles when assessing dose enhancing potential in cancer therapy.

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Section: Demonstrated 14 Nm Triphenyl Monosulfonate (Tppms)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy

Butterworth¹,

Coulter²,

Jain³

et al. 2010

Nanotechnology

208

160

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“…The physical principle of photon activation therapy (PAT) consists of increasing the local release of energy (photoelectrons and Auger-electrons) that result from the photoeffect arising when the soft X-ray radiation interacts with atoms of elements with large atomic number Z [5][6][7], herewith prospects for use of gold nanoparticles in the PAT are shown in several publications [8,9]. This type of radiation therapy is most suitable for wide use in oncology practice since X-ray sources are mobile, relatively cheap and do not require special rooms with a powerful biological protection when operating and that creates conditions for PAT widespread use in the treatment of cancer patients.…”

Section: Introductionmentioning

confidence: 99%

The study of hyaluronic acid compounds for neutron capture and photon activation therapies

et al. 2014

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Abstract:The therapy of radioresistant tumors remains an urgent problem in medicine. To solve this problem neutron capture therapy (NCT) and photon activation therapy (PAT) are used. The essential feature of this such technique is the uptake of tumor chemical elements, which interact with thermal neutrons (NCT) and X-rays (PAT). The aims of the investigation were to study a biodistribution of the complexes of hyaluronic acid with boron (3 mg B mL -1 ) and gold (20 mg Au mL -1 ) in mice with melanoma B-16 after intratumoral administration. An optimal time for NCT was 30 minutes after administration when boron concentration in the tumor was more than 30 µg g -1 and exceeded boron content in surrounding tissues. The maximal gold content in tumor (180-260 mg g -1 ) was obtained in 30 minutes after the preparation introduction. The highest ratios of gold in tumor and surrounding tissues (a necessary condition for forming of the local absorbed dose in tumor) was obtained in 0.5 and 1 h. On the basis of the data obtained, it is possible to assume the perspectives of the non-toxic boron compounds for use in NCT and the gold compounds for use primarily as contrast agents for diagnostic purposes.

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“…Analysis of dose-response curves has implied that a dose enhancement factor of 1.37 for gold nanoparticles irradiated with the electron beam has been observed. Rahman et al [9] have used gold nanoparticles in another study for enhancement of cell damage by irradiation of bovine aortic endothelial cells by use of superfi cial X-rays and megavoltage electron beams. With an increase in the concentration of gold nanoparticles, the cell damage has shown to increase.…”

mentioning

confidence: 99%

A Monte Carlo study on dose enhancement and photon contamination production by various nanoparticles in electron mode of a medical linac

Toossi

Ghorbani

Sabet³

et al. 2015

Nukleonika

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The aim of this study is the evaluation of electron dose enhancement and photon contamination production by various nanoparticles in the electron mode of a medical linac. MCNPX Monte Carlo code was used for simulation of Siemens Primus linac as well as a phantom and a tumor loaded with nanoparticles. Electron dose enhancement by Au, Ag, I and Fe2O3 nanoparticles of 7, 18 and 30 mg/ml concentrations for 8, 12 and 14 MeV electrons was calculated. The increase in photon contamination due to the presence of the nanoparticles was evaluated as well. The above effects were evaluated for 500 keV and 10 keV energy cut-offs defined for electrons and photons. For 500 keV energy cut-off, there was no significant electron dose enhancement. However, for 10 keV energy cut-off, a maximum electron dose enhancement factor of 1.08 was observed for 30 mg/ml of gold nanoparticles with 8 MeV electrons. An increase in photon contamination due to nanoparticles was also observed which existed mainly inside the tumor. A maximum photon dose increase factor of 1.07 was observed inside the tumor with Au nanoparticles. Nanoparticles can be used for the enhancement of electron dose in the electron mode of a linac. Lower energy electron beams, and nanoparticles with higher atomic number, can be of greater benefit in this field. Photons originating from nanoparticles will increase the photon dose inside the tumor, and will be an additional advantage of the use of nanoparticles in radiotherapy with electron beams.

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Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy

Cited by 324 publications

References 21 publications

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy

Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy

The study of hyaluronic acid compounds for neutron capture and photon activation therapies

A Monte Carlo study on dose enhancement and photon contamination production by various nanoparticles in electron mode of a medical linac

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