The study of hyaluronic acid compounds for neutron capture and photon activation therapies

Abstract

Abstract:The therapy of radioresistant tumors remains an urgent problem in medicine. To solve this problem neutron capture therapy (NCT) and photon activation therapy (PAT) are used. The essential feature of this such technique is the uptake of tumor chemical elements, which interact with thermal neutrons (NCT) and X-rays (PAT). The aims of the investigation were to study a biodistribution of the complexes of hyaluronic acid with boron (3 mg B mL -1 ) and gold (20 mg Au mL -1 ) in mice with melanoma B-16 after intratumoral administration. An optimal time for NCT was 30 minutes after administration when boron concentration in the tumor was more than 30 µg g -1 and exceeded boron content in surrounding tissues. The maximal gold content in tumor (180-260 mg g -1 ) was obtained in 30 minutes after the preparation introduction. The highest ratios of gold in tumor and surrounding tissues (a necessary condition for forming of the local absorbed dose in tumor) was obtained in 0.5 and 1 h. On the basis of the data obtained, it is possible to assume the perspectives of the non-toxic boron compounds for use in NCT and the gold compounds for use primarily as contrast agents for diagnostic purposes.

THE PHOTON CAPTURE THERAPY MODEL FOR IN VIVO AND IN VITRO STUDIES USING Au NANOCOMPOSITES WITH THE HYALURONIC ACID BASED COMPOUNDS

“…The max energy is 210 keV. The concentration of Au within the compound for PCT has been chosen by the evaluation of the minimal significant metal concentration to initiate the capture events on Au (no less the 10 mg per 1 g of tumor tissue) [10]) and our own in vivo experimental data of the dose enhancement with the low Au concentration (2 mg per 1 g of tissue) [5].…”

Synthesis of gold complex compounds for cancer diagnostics and obtaining nanocomposite materials based on polylactide

“…Для этого используются специальные соединения, содержащие элементы с порядковым номером Z > 52 (I, Gd, Au, Bi и др.). На сегодняшний день основной проблемой в ФЗТ является синтез безопасных для организма препаратов с высокими фотонзахватными свойствами и обладающие способностью накапливаться в опухолевых клетках [1]. Многообещающим направлением в ФЗТ может стать получение препаратов на основе нанокомпозитных материалов.…”

Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

“…Boron neutron capture therapy (BNCT) is one of the promising areas in radiotherapy [1]. The main feature of BNCT is the possibility of a local increase in the absorbed dose in the tumor with virtually no effect on healthy tissues [2]. Compounds containing the boron-10 isotope are used in BNCT, and heavy elements, such as gold, can be used to measure the absorbed dose [3,4].…”