Enhancement of phenolic and flavonoids compounds, antioxidant and cytotoxic effects in regenerated red cabbage by application of Zeatin

Ravanfar, Seyed Ali; Karimi, Ehsan; Mehrabanjoubani, Pooyan; Ebrahimi, Mahdi

doi:10.1080/14786419.2018.1508145

Cited by 18 publications

(12 citation statements)

References 15 publications

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“…Indeed, the antioxidant activity on DPPH, expressed as IC50 in μg / mL, of several species of the genus Dialium is reported in the literature, D. indum, 181.6 ± 0.4 [33,34], D. guineense, 50.23 ± 0.15 [35], D. corbisieri, 14.44 ± 0.12 and D. gossweileri, > 500 [36], D. cochinchinensis, 65.01 ± 0.12 [37]. This interesting antioxidant activity observed in D. angolense would be linked to the presence of phenolic compounds mainly flavonoids, identified and quantified within the plant during this study (table 2), as well as several previous studies which testify to the antioxidant activity of flavonoids [38][39][40][41][42]. Besides flavonoids, other antimalarial [43,44] and antioxidant [45][46][47] compounds belonging from other phytochemical groups identified in the leaves of D. angolense during this study has been isolate.…”

Section: Discussionsupporting

confidence: 77%

In vivo antiplasmodial and toxicological studies of Dialium angolense Welw. Ex Oliv. (Fabaceae) leaves extracts, a medicinal plant from Eastern Congo

Valentin¹,

Salvius²,

Henry³

et al. 2020

World J. Bio. Pharm. Health Sci.

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Dialium angolense is used in traditional medicine in Bagira-Bukavu in the management of malaria. In this study, in vivo antiplasmodial and in vitro antioxidant activities, phytochemical screening of secondary metabolic and in vivo toxicological studies where carried out on aqueous and methanolic extracts of its leaves. The plant was selected following an ethnobotanical survey conducted in DR Congo and focusing on antimalarial plants. Extracts’ phytochemical secondary metabolites were determined using standard procedures and the antiplasmodial activity was evaluated using 4-day suppressive test, while antioxidant activity was evaluated by DPPH assay. In acute toxicity, eighteen animal (6/group) were given orally singular 2000 mg of extract/kg body weight (BW) then observed for 14 days. In sub-acute toxicity assay, 150 or 300 mg/kg BW/Day were given orally, and animals (6/group) were observed for 28 days. The total phenolic (0.89 - 0.98 mg GAEg-1), total flavonoid (0.42 - 0.44 mg QEg-1) and total tannin contents (0.080 – 0.098 mg GAEg-1) were in the same rate in the two extracts as well as the antioxidant activity with IC50 value 6.1 and 6.8 μg/mL. At the highest oral dose, 300 mg/kg body weight, all extracts produced 70.4–70.8% chemo-suppression against P. berghei ANKA and 28 survival days. No deaths were recorded during the acute toxicity assay suggesting the LD50 > 2000 mg/kg and no abnormal behavior or variation in toxicity biomarkers were observed during the subacute toxicity assessment. D. angolense leaves extracts showed a great antiplasmodial and a very good antioxidant activity. It can be used to prepare antimalarial recipe or isolate antimalarial compounds in the future.

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Section: Discussionsupporting

confidence: 77%

In vivo antiplasmodial and toxicological studies of Dialium angolense Welw. Ex Oliv. (Fabaceae) leaves extracts, a medicinal plant from Eastern Congo

Valentin¹,

Salvius²,

Henry³

et al. 2020

World J. Bio. Pharm. Health Sci.

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“…[6] In the past decade, the interest and use of medicinal plant products have increased significantly . [7] Therefore, more and more researchers begin to pay attention to a variety of bioactive substances in plants, fruits and vegetables and their importance to human health, such as Borago officinalis L. flower, [8] Galanthus transcaucasicus, [9] red cabbage, [10] Clematis orientalis and Clematis ispahanica . [11] Jujube have always been regarded as an important food or traditional medicinal material.…”

Section: Introductionmentioning

confidence: 99%

Active components and antioxidant activity of thirty-seven varieties of Chinese jujube fruits (Ziziphus jujuba Mill.)

Zhang

Sun

Vidyarthi

et al. 2021

International Journal of Food Properties

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Jujube has received more and more attention due to their nutritional value and pharmacological effects. This study evaluated the quality of different varieties of jujube by comparing the main active components and antioxidant activities of thirty-seven varieties of jujube through titration, UV spectrophotometry and High performance liquid chromatography (HPLC). The results revealed that there were differences in active components and antioxidant capacity among jujube cultivars. Among the thirty-seven varieties of jujube, Qingxuyuanzao (QXYZ) had the highest contents of total phenols and flavonoids, which were 16.33 mg GAE/g DW and 41.18 mg RE/g DW, respectively, and had the highest free radical scavenging (DPPH: 29.79 mg Vc/g DW; ABTS: 50.90 mg Trolox/g DW) and reducing abilities (62.13 mg Trolox/g DW). Correlation analysis indicated that the content of total flavonoids, total phenols and phenolic acid ((+)catechin, caffeic acid, rutin) in jujube had high positive correlation with antioxidant capacity. According to principal component analysis (PCA), the comprehensive scores of different varieties of jujube were calculated. The top five jujube varieties with comprehensive scores are 'QXYZ,' Suyuanling (SYL), Xiangzao (XZ), Dunhuangdazao (DHDZ) and Meimizao (MMZ). In this paper, the main active components and antioxidant capacity of thirty-seven jujube varieties have been studied, which provides a theoretical basis for jujube breeding and the development of active nutrients for jujube.

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“…phenol can be used as a prevention or treatment for diseases caused by oxidative stress. Besides that, phenol also has a strong antibacterial function, especially against gram-positive bacteria (Fu et al, 2010;Ravanfar, Karimi, Mehrabanjoubani, & Ebrahimi, 2020). TLC results of KD 4 sorghum seed varieties contain phytochemicals which have been instrumental in the treatment of various diseases, in this case sorghum seeds have potential as medicinal plants which can be developed into various pharmaceutical products.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Screening of Sorghum (Sorghum Sp) with Thin Layer Chromatography Method

Noerhartati

Rizal

Joeniarti

2020

scj

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Sorghum is a food plant rich in benefits and has the advantage of being free gluten; it contains antioxidants and has a low glycemic index. The purpose of this research is to determine the content of compounds in sorghum. In the research, the variety of KD 4 sorghum has been used, which was macerated by absolute methanol. Results screening using thin-layer chromatography showed that methanol extract of sorghum contained flavonoid, phenol, triterpenoid, tannin, and saponin compounds, and finally, these compounds will be useful for pharmaceutical products.

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Enhancement of phenolic and flavonoids compounds, antioxidant and cytotoxic effects in regenerated red cabbage by application of Zeatin

Cited by 18 publications

References 15 publications

In vivo antiplasmodial and toxicological studies of Dialium angolense Welw. Ex Oliv. (Fabaceae) leaves extracts, a medicinal plant from Eastern Congo

In vivo antiplasmodial and toxicological studies of Dialium angolense Welw. Ex Oliv. (Fabaceae) leaves extracts, a medicinal plant from Eastern Congo

Active components and antioxidant activity of thirty-seven varieties of Chinese jujube fruits (Ziziphus jujuba Mill.)

Phytochemical Screening of Sorghum (Sorghum Sp) with Thin Layer Chromatography Method

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