Enhancement of peripheral blood CD56dim cell and NK cell cytotoxicity in women with recurrent spontaneous abortion or in vitro fertilization failure

Karami, Najmeh; Boroujerdnia, Mehri Ghafourian; Nikbakht, Roshan; Khodadadi, Ali

doi:10.1016/j.jri.2012.06.005

Cited by 68 publications

(46 citation statements)

References 28 publications

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“…Therefore, we investigated whether a compensatory mechanism limiting dNK activation at the MFI could be induced by HCV sensing. There is evidence that increased pNK cells and activated NK cells are associated with increased risk of miscarriage and failed in vitro fertilization treatment (47, 48). The healthy trophoblast does not express classical HLA-A and HLA-B products; however, trophoblasts do express the non-classical MHC class I molecule HLA-E, the ligand for the inhibitory CD94/NKG2A and activating CD94/NKG2C receptors (49).…”

Section: Resultsmentioning

confidence: 99%

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission

Giugliano

Petroff

Warren

et al. 2015

The Journal of Immunology

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Hepatitis C virus (HCV) is the world’s most common blood-borne viral infection for which there is no vaccine. The rates of vertical transmission range between 3–6% with odds 90% higher in the presence of HIV co-infection. Prevention of vertical transmission is not possible due to lack of an approved therapy for use in pregnancy or an effective vaccine. Recently, HCV has been identified as an independent risk factor for pre-term delivery, perinatal mortality and other complications. In this study, we characterized the immune responses that contribute to the control of viral infection at the maternal-fetal interface (MFI) in the early gestational stages. Here we show that primary human trophoblast cells and an extravillous trophoblast cell line (HTR8), from first and second trimester of pregnancy, express receptors relevant for HCV binding/entry and are permissive for HCV-uptake. We found that HCV-RNA sensing by human trophoblast cells induces robust up-regulation of Type I/III IFNs and secretion of multiple chemokines that elicit recruitment and activation of decidual NK cells. Furthermore, we observed that HCV-RNA transfection induces a pro-apoptotic response within HTR8 that could affect the morphology of the placenta. For the first time, we demonstrate that HCV-RNA sensing by human trophoblast cells elicits a strong antiviral response that alters the recruitment and activation of innate immune cells at the MFI. This work provides a paradigm shift in our understanding of HCV-specific immunity at the MFI, as well as novel insights into mechanisms that limit vertical transmission, but may paradoxically lead to virus-related pregnancy complications.

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Section: Resultsmentioning

confidence: 99%

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission

Giugliano

Petroff

Warren

et al. 2015

The Journal of Immunology

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“…This is in line with the observations in W-rats. Moreover, increased numbers of peripheral NK-cells during human pregnancy have been associated with recurrent spontaneous abortion [37]. This may suggest that increased numbers of NK-cells in pregnant BBDP-rats may be involved in increased numbers of resorptions in these rats.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model

et al. 2013

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IntroductionDespite tight glycemic control, pregnancy complication rate in type 1 diabetes patients is higher than in normal pregnancy. Other etiological factors may be responsible for the development of adverse pregnancy outcome. Acceptance of the semi-allogeneic fetus is accompanied by adaptations in the maternal immune-response. Maladaptations of the immune-response has been shown to contribute to pregnancy complications. We hypothesized that type 1 diabetes, as an autoimmune disease, may be associated with maladaptations of the immune-response to pregnancy, possibly resulting in pregnancy complications.MethodsWe studied pregnancy outcome and pregnancy-induced immunological adaptations in a normoglycemic rat-model of type 1 diabetes, i.e. biobreeding diabetes-prone rats (BBDP; 5 non-pregnant rats, 7 pregnant day 10 rats and 6 pregnant day 18 rats) , versus non-diabetic control rats (i.e. congenic non-diabetic biobreeding diabetes-resistant (BBDR; 6 non-pregnant rats, 6 pregnant day 10 rats and 6 pregnant day 18 rats) and Wistar-rats (6 non-pregnant, 6 pregnant day 10 rats and 5 pregnant day 18 rats)).ResultsWe observed reduced litter size, lower fetal weight of viable fetuses and increased numbers of resorptions versus control rats. These complications are accompanied by various differences in the immune-response between BBDP and control rats in both pregnant and non-pregnant animals. The immune-response in non-pregnant BBDP-rats was characterized by decreased percentages of lymphocytes, increased percentages of effector T-cells, regulatory T-cells and natural killer cells, an increased Th1/Th2-ratio and activated monocytes versus Wistar and BBDR-rats. Furthermore, pregnancy-induced adaptations in BBDP-rats coincided with an increased Th1/Th2-ratio, a decreased mean fluorescence intensity CD161a/NKR-P1b ratio and no further activation of monocytes versus non-diabetic control rats.ConclusionThis study suggests that even in the face of strict normoglycemia, pregnancy complications still occur in type 1 diabetic pregnancies. This adverse pregnancy outcome may be related to the aberrant immunological adaptations to pregnancy in diabetic rats.

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“…They have announced that according to abundant population of NKs in decidua they must per se perform physiologic and not pathologic functions. They also cited from Karami et al (14) that no significant correlation is observed between increase of CD56 bright and RSA patients. Of course increase of CD56 dim in RSA was non-controversial and successive in previous original studies.…”

Section: Introductionmentioning

confidence: 91%

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

Ahmadi¹,

Shahsavar²,

Akbari³

2016

IJWHR

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IntroductionAmong the controversies in reproduction science, role of immune and inflammatory systems in implantation process and durability of pregnancy is a hot topic nowadays. Some researchers and practitioners believe that administration of drugs such as prednisolone, aspirin or heparin can improve success rate of implantation and pregnancy through inhibiting coagulation, inflammatory and immune systems; while others believe that such systems not only do not have negative effect on rejecting blastocyst and embryo by itself but also are necessary for implantation and remodeling of uterine spiral arteries through secreting adhesive and angiogenic factors. Such controversies are proposed both in natural pregnancies resulting in spontaneous abortion as well as in successful and/or unsuccessful assisted reproductive technologies (ARTs). Recurrent spontaneous abortion (RSA) is defined as having 3 or more history of abortion (1). About the other issue, some researchers and practitioners are grumbling of low success rate of ARTs like in vitro fertilization (IVF). Infertility is a problem for 10%-15% of couples; most of which -but not all -require ART (2). The average fertilization rate of ART in previous researches has been reported about 30% (3) and this report is for 1998. It has been claimed in an article published in 2015 that this rate has improved in the recent decade (4). Even though at the first glance this rate seems low, but the interesting point is that in the claim of a valid reference (5) the chance of natural pregnancy for each intercourse per month does not go up more than 33%. Also this number has been reported in some studies up to 40% (6). Thus, we should not be grumbling of the low fertilization rate of ARTs. Finally we intend to represent and report our insights, reasoning and suggestions in the present review. MethodsThis systematic and critical review includes investigation of scientific data bases and tracing the citations and the references of the articles in order to find the root of the truth. Through this wisdom, we showed the mere that a content proposed in an indexed article is not a reason that this content is valid and able to be cited. Indeed, the researcher should regard and notice the reasoning, citations and protocol of his/her references during the literature review. This is the benefit point of systematic review rather than holistic and narrative reviews. Since some data were few, the time period of publications was not important to us. As the searching strategy, we used the Web of Science Core Collection and Google Scholar for finding articles other than ISI-WOS and the tracing mentioned in the above paragraph. Results and DiscussionRole of Immune System and Leukocytes In 2015, Ghafourian et al (1) by measuring the level of natural killer-cells (NKs) in blood of the RSA and the control group concluded that RSA patients in normal (non-preg- AbstractAmong the controversies about reproduction sciences, role of immune and inflammatory systems in implantation process and durability of...

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Enhancement of peripheral blood CD56dim cell and NK cell cytotoxicity in women with recurrent spontaneous abortion or in vitro fertilization failure

Cited by 68 publications

References 28 publications

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission

Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission

Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

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