Enhancement of Perineurial Repair and Inhibition of Nerve Adhesion by Viscous Injectable Pure Alginate Sol

Ohsumi, Hidehiko; Hirata, Hitoshi; Nagakura, Takeshi; Tsujii, Masaya; Sugimoto, Toshiko; Miyamoto, Keiichi; Horiuchi, Takashi; Nagao, Masahiro; Nakashima, T.; Uchida, Atsushi

doi:10.1097/01.prs.0000176893.44656.8e

Cited by 33 publications

(33 citation statements)

References 14 publications

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“…In addition to its high residence time, alginate is known to significantly inhibit the expression of pro-inflammatory cytokines such as interleukin-1β and tumor necrosis factor α, supporting a potential role in downregulating the inflammatory response at the wound site [28]. Experimental evidence has also revealed that β-D mannuronic acid, a constituent of alginate, acts as a novel non-steroidal drug, attenuating inflammatory reactions [29]. Despite better characteristics in this respect, the gel did not outperform most barriers regarding prevention of adhesion reformation.…”

Section: Discussionmentioning

confidence: 97%

Ultrapure alginate gel reduces adhesion reformation after adhesiolysis

Chaturvedi

Lomme

Hendriks

et al. 2014

Int J Colorectal Dis

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Section: Discussionmentioning

confidence: 97%

Ultrapure alginate gel reduces adhesion reformation after adhesiolysis

Chaturvedi

Lomme

Hendriks

et al. 2014

Int J Colorectal Dis

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“…Six weeks after surgery, 48 nerves ( n = 9 in each operated group, and n = 12 in the Normal group) were subjected to biomechanical testing to assess ultimate breaking strength using a published method 11. Briefly, sciatic nerves were exposed under anesthesia, and transected 5 mm proximal to the site of neurolysis.…”

Section: Methodsmentioning

confidence: 99%

“…The rational development and use of chemical compounds to prevent postoperative scarring has recently become possible. Sodium hyaluronan (Artz®; Seikagaku, Tokyo), a polyglycan ester gel (Adcon‐T/N; Gliatech, Cleveland, OH), pure alginate solution (Kuraray Medical, Tokyo), and autocross‐linked polysaccharide gel (Hyaloglide®; Fidia Advanced Biopolymers, Abano Terme, Italy) have all shown promise for preventing postoperative fibrosis in animal models 5, 9–12. However, cases of cerebrospinal fluid leakage after the use of carbohydrate polymer gel in spinal surgery have been reported 13.…”

mentioning

confidence: 99%

Novel Polysaccharide‐derived hydrogel prevents perineural adhesions in a rat model of sciatic nerve adhesion

Yamamoto

Endo

Ito

et al. 2009

Journal Orthopaedic Research

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ABSTRACT:We investigated the effects of a novel carboxymethylcellulose (CMC)-derived hydrogel, in which phosphatidylethanolamine (PE) was introduced into the carboxyl groups of CMC, for preventing perineural adhesion after extensive internal neurolysis of rat sciatic nerve. Sciatic nerves were randomly assigned to one of the following groups: the Control group, operated but no treatment; the HA group, operated and treated with 1% hyaluronan; the CMC-PE(L) group, operated and treated with low-viscosity CMC-PE hydrogel; and the CMC-PE(H) group, operated and treated with high-viscosity CMC-PE hydrogel. Perineural adhesions were evaluated at 6 weeks. Nerves were also subjected to biomechanical testing to assess ultimate breaking strength. Electrophysiological and wet muscle weight measurements were performed. Breaking strengths were significantly lower for the CMC-PE(L) group than for the Control and HA groups. Latency was significantly longer for the Control group than for the CMC-PE(L) group at 20 days. The mean percentage of wet muscle weight to body weight was significantly lower for the Control group than for the CMC-PE(L) group at 6 weeks. Low-viscosity CMC-PE hydrogel appears to prevent perineural adhesions and allow early restoration of nerve function. ß

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“…To stimulate local fibrotic response around the nerve, the surface of the biceps femoris muscle-composing neural bed was repeatedly burned using an electrocoagulator while the exposed nerves were gently retracted and protected. 11 After neurolysis, the right nerve was wrapped with a 1-cm 2 piece of honeycomb film (group H) (Fig. 2), while the left nerve was left untreated as a control (group C).…”

Section: Methodsmentioning

confidence: 99%

Artificial perineurium to enhance nerve recovery from damage after neurolysis

et al. 2010

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We have developed a novel biodegradable poly-lactide (PLA) film (honeycomb film) with a micropatterned porous structure on one side. We hypothesized that this film could be used as a substitute for perineurium. We used two types of thin PLA film: honeycomb film and cast film with smooth surfaces on both sides. In a rat extensive internal neurolysis model, the nerve was wrapped with honeycomb film (group H) or cast film (group CA), or left unwrapped (group C). Histological and functional analyses were performed. The honeycomb film closely attached to the nerve surface but did not adhere to surrounding tissues. In contrast, nerves in group C displayed severe adhesion to the neural bed. Mean percent wet muscle weight and motor nerve conduction velocity were significantly higher in group H than in group C. The honeycomb film prevents nerve adhesion and enhances functional recovery after extensive neurolysis.

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Enhancement of Perineurial Repair and Inhibition of Nerve Adhesion by Viscous Injectable Pure Alginate Sol

Cited by 33 publications

References 14 publications

Ultrapure alginate gel reduces adhesion reformation after adhesiolysis

Ultrapure alginate gel reduces adhesion reformation after adhesiolysis

Novel Polysaccharide‐derived hydrogel prevents perineural adhesions in a rat model of sciatic nerve adhesion

Artificial perineurium to enhance nerve recovery from damage after neurolysis

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