Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults

Terao, Keiji; Nakata, Daisuke; Fukumi, Hiroshi; Schmid, G. M.; Arima, Hisatomi; Hirayama, Fumitoshi; Uekama, Kaneto

doi:10.1016/j.nutres.2006.08.004

Cited by 84 publications

(49 citation statements)

References 20 publications

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“…However, there was a difference among individuals in intrinsic CoQ10 levels, as previously reported (15,25,26,33), and also in absorbed CoQ10 levels (34). In human studies, the experimental conditions largely affect the bioavailability of CoQ10.…”

Section: Discussionsupporting

confidence: 73%

“…Addition of the oils commonly used in CoQ 10 soft capsules, or of surfactants such as polysorbates, also increases the bioavailability of CoQ 10 (25,26). The CoQ 10 formulation created with cyclodextrin, for example, has increased bioavailability (15,27). Emulsification is important for increasing the bioavailability of this lipophilic substance.…”

Section: Discussionmentioning

confidence: 99%

“…Because of its lipophilia, CoQ 10 is poorly absorbed in humans when taken orally, especially under fasting conditions ( 15 , 16 ). Therefore, various methods of emulsification with modified food starch ( 17 ), lecithin ( 18 ), gum arabic ( 19 ), or polysorbate 80 ( 18 , 20 ), or inclusion of ␥ -cyclodextrin ( 15 ), have been used to decrease the hydrophobicity of CoQ 10 . The strategy of emulsification of drugs to decrease hydrophobicity and boost bioavailability has already been used and reported ( 21 , 22 ).…”

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confidence: 99%

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Emulsification of Coenzyme Q<sub>10</sub> Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability

Ozaki

Muromachi

Sumi

et al. 2010

J Nutr Sci Vitaminol

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Emulsification of Coenzyme Q<sub>10</sub> Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability

Ozaki

Muromachi

Sumi

et al. 2010

J Nutr Sci Vitaminol

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“…In this context, we studied the effect of natural α, β and γCDs on the aqueous solubility and bioavailability of some hydrophobic nutra-ceuticals such as Coenzyme Q10 (CoQ10) [5][6][7], Curcumin [8,9], Tocotrienol [10], R-α-Lipoic acid [11], Menaquinone-7 (Vitamin K 2 ) and Astaxanthin. Complex formations with all natural CDs do not help to enhance aqueous solubility of such nutra-ceuticals in general.…”

Section: Introductionmentioning

confidence: 99%

A New Generation of Nutra-ceuticals and Cosme-ceuticals Complexing lipophilic bioactives with γ-Cyclodextrin

Uekaji¹,

Jo²,

Ohnishi³

et al. 2012

Trans. Mat. Res. Soc. Japan

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We previously reported the bioavailability enhancement of lipophilic Coenzyme Q10 (CoQ10) by complexing with γ-Cyclodextrin (γCD) in spite of poorly-soluble characteristics in water. We recently found the most plausible explanation mechanism which is due to the significant increase of water solubility of CoQ10 with the aid of sodium taurocholate (Na TCA) as a major component of bile acid in small intestine. By adding Na TCA into a water suspension of CoQ10-γCD complex, water soluble Na TCA-γCD complex is formed by the substitution of guest molecule from CoQ10 to Na TCA since Na TCA has higher association constant with γCD than CoQ10. Generally CoQ10 molecule agglutinates in water to form visible particles. But the dissociated CoQ10 from γCD cavity could be significantly solubilized in water captured in the midst of Na TCA micelle. This method could be applied for the other nutra-ceuticals like Curcumin and R-α-Lipoic acid. In the wake of the breakthrough projects using various nutra-ceutical-γCD complexes and Na TCA, we could also establish this new nanotech formulation system in personal care field by the combination of cosme-ceutical-γCD complexes with a cosmetic ingredient, dipotassium glycyrrhizate (GZK 2 ) which has high association constant as well as Na TCA.

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“…또한 coenzyme Q 10 의 경우 구조상 큰 잔기를 포함하고 있기 때문에 포접할 수 있는 내부공동이 가장 큰 γ-cyclodextrin 이 복합체를 형성할 수 있는 확률이 가장 크기 때문에 coenzyme Q 10 과 복합체를 형성함에 있어 가장 유리할 것이라고 보고하였다 (28)(29)(30)(31). 뿐만 아니라 coenzyme Q 10 -cyclodextrin 복합체를 제조후 복합체의 용해도, 열 및 광 안정성 개선, 생체이용율 개선을 보 고한바 있다 (32)(33)(34)(35).…”

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Structural and Solubility Characteristics of Coenzyme Q₁₀Complexes Including Cyclodextrin and Starch

이준경¹,

이현주²,

임재각³

2014

Korean Journal of Food Science and Technology

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This study focused on assessing the solubility and structural characteristics of two types of coenzyme Q 10 (CoQ 10 ) complexes: the CoQ 10 -starch and the CoQ 10 -cyclodextrin complexes. The solubility of CoQ 10 -starch complex increased significantly as the temperature was increased. However, the solubility of CoQ 10 -cyclodextrin complex reached a peak at 37 o C, and strong aggregation occurred at 50 o C. When the temperature was raised to 80 o C, the CoQ 10 -cyclodextrin complex dissociated owing to the weakening of bonds, resulting in CoQ 10 emerging at the surface of water. Therefore, CoQ 10 -cyclodextrin complexes have lower solubility, due to their reduced heat-stability, than do the CoQ 10 -starch complexes. Structural differences between the two CoQ 10 complexes were confirmed by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffractometer (XRD), and differential scanning calorimeter (DSC). The CoQ 10 -cyclodextrin complex included an isoprenoid chain of CoQ 10 , while the CoQ 10 -starch complex included both the benzoquinone ring and the isoprenoid chain of CoQ 10 . These results suggest that CoQ 10 -starch complexes possess higher heat-stability and solubility than do the CoQ 10 -cyclodextrin complexes.

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Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults

Cited by 84 publications

References 20 publications

Emulsification of Coenzyme Q<sub>10</sub> Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability

Emulsification of Coenzyme Q<sub>10</sub> Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability

A New Generation of Nutra-ceuticals and Cosme-ceuticals Complexing lipophilic bioactives with γ-Cyclodextrin

Structural and Solubility Characteristics of Coenzyme Q₁₀Complexes Including Cyclodextrin and Starch

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Enhancement of oral bioavailability of coenzyme Q10 by complexation with γ-cyclodextrin in healthy adults

Cited by 84 publications

References 20 publications

Emulsification of Coenzyme Q<sub>10</sub> Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability

Emulsification of Coenzyme Q<sub>10</sub> Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability

A New Generation of Nutra-ceuticals and Cosme-ceuticals Complexing lipophilic bioactives with γ-Cyclodextrin

Structural and Solubility Characteristics of Coenzyme Q10Complexes Including Cyclodextrin and Starch

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Structural and Solubility Characteristics of Coenzyme Q₁₀Complexes Including Cyclodextrin and Starch