Structural and Solubility Characteristics of Coenzyme Q₁₀Complexes Including Cyclodextrin and Starch

Abstract

This study focused on assessing the solubility and structural characteristics of two types of coenzyme Q 10 (CoQ 10 ) complexes: the CoQ 10 -starch and the CoQ 10 -cyclodextrin complexes. The solubility of CoQ 10 -starch complex increased significantly as the temperature was increased. However, the solubility of CoQ 10 -cyclodextrin complex reached a peak at 37 o C, and strong aggregation occurred at 50 o C. When the temperature was raised to 80 o C, the CoQ 10 -cyclodextrin complex dissociated owing to the weakening of bonds, resulting in CoQ 10 emerging at the surface of water. Therefore, CoQ 10 -cyclodextrin complexes have lower solubility, due to their reduced heat-stability, than do the CoQ 10 -starch complexes. Structural differences between the two CoQ 10 complexes were confirmed by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffractometer (XRD), and differential scanning calorimeter (DSC). The CoQ 10 -cyclodextrin complex included an isoprenoid chain of CoQ 10 , while the CoQ 10 -starch complex included both the benzoquinone ring and the isoprenoid chain of CoQ 10 . These results suggest that CoQ 10 -starch complexes possess higher heat-stability and solubility than do the CoQ 10 -cyclodextrin complexes.

Development of Anti-aging Cosmetics Using Chitosan/ γ-Cyclodextrin/Fucoidan Nanoparticles (Nanogel) Based on the Drug Delivery System

“…이러한 CD의 내부는 C-H와 글루코시드 산소만이 존재하여 소수성 (hydrophobic)을 나타낸다. 각종 소수성 화합물인 guest 물질을 포 접시켜 복합체를 형성할 수 있다 (Lee et al, 2014). CD가 다양한 유 기 분자와 복합체를 형성하는 능력과 잘 용해되지 않는 약물을 용해 시키는 능력은 이미 잘 확립되어 있으며, CD를 포함하는 Nanogel은 Drug Delivery System에서 유용 성분을 전달하는 생물 의약 분야의 유망 하다 (Maria et al, 2012).…”