Enhancement of optical coherence microscopy in turbid media by an optical parametric amplifier

Zhao, Youbo; Tu, Haohua; Liu, Yuan; Bower, Andrew J.; Boppart, Stephen A.

doi:10.1002/jbio.201400073

Cited by 6 publications

(3 citation statements)

References 48 publications

(91 reference statements)

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“…Although optical amplification is generally essential to compensate for the dispersive loss in time-stretch operation 16 , 18 , 19 , the low-loss characteristics of FACED intriguingly make optical amplification less critical, even at high GVD. Because optical amplifiers that operate in the visible wavelength regime and are compatible with time-stretch imaging are not readily available and usually necessitate a bulky system architecture (for example, an optical parametric amplifier 36 ), this relaxation of the requirement for optical amplification thus renders FACED a unique approach for efficient time-stretch imaging in this once-forbidden short-wavelength window.…”

Section: Resultsmentioning

confidence: 99%

Ultrafast laser-scanning time-stretch imaging at visible wavelengths

et al. 2016

Light Sci Appl

141

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Optical time-stretch imaging enables the continuous capture of non-repetitive events in real time at a line-scan rate of tens of MHz—a distinct advantage for the ultrafast dynamics monitoring and high-throughput screening that are widely needed in biological microscopy. However, its potential is limited by the technical challenge of achieving significant pulse stretching (that is, high temporal dispersion) and low optical loss, which are the critical factors influencing imaging quality, in the visible spectrum demanded in many of these applications. We present a new pulse-stretching technique, termed free-space angular-chirp-enhanced delay (FACED), with three distinguishing features absent in the prevailing dispersive-fiber-based implementations: (1) it generates substantial, reconfigurable temporal dispersion in free space (>1 ns nm−1) with low intrinsic loss (<6 dB) at visible wavelengths; (2) its wavelength-invariant pulse-stretching operation introduces a new paradigm in time-stretch imaging, which can now be implemented both with and without spectral encoding; and (3) pulse stretching in FACED inherently provides an ultrafast all-optical laser-beam scanning mechanism at a line-scan rate of tens of MHz. Using FACED, we demonstrate not only ultrafast laser-scanning time-stretch imaging with superior bright-field image quality compared with previous work but also, for the first time, MHz fluorescence and colorized time-stretch microscopy. Our results show that this technique could enable a wider scope of applications in high-speed and high-throughput biological microscopy that were once out of reach.

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Section: Resultsmentioning

confidence: 99%

Ultrafast laser-scanning time-stretch imaging at visible wavelengths

et al. 2016

Light Sci Appl

141

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“…Optical coherence tomography (OCT) is a robust imaging technology that utilizes back‐reflecting light to reconstruct the three‐dimensional (3D) images of biological tissues with micrometer resolution . As a real‐time imaging modality, OCT has proven to be a powerful diagnostic tool in various aspects of medicine such as dermatology, ophthalmology and cardiology .…”

Section: Introductionmentioning

confidence: 99%

Retroreflective‐type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography

Zhang

Liu

Wang

et al. 2016

Journal of Biophotonics

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Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In this study, Janus microspheres were developed and used as a positive contrast agent for enhanced OCT imaging. Phantom and ex vivo liver tissue experiments as well as in vivo animal tests were conducted, which validated that Janus microspheres, as a novel type of OCT tracer, were very effective in improving the OCT imaging contrast. Working principle and SEM image of Janus microsphere (top). Enhanced OCT imaging (bottom) of Janus microspheres in zebrafish stomach (blue dash line) and sinusoids (green arrows) of nude liver.

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“…Zhu et al, Xu et al, and Yu et al reported dual-band and tri-band SS-OCT systems, which expanded the working bandwidth of SS-OCT systems, thus improved the resolution through generating an idler band by using the FDML laser's output as the signal to the fiber optical parametric process [23][24][25]. Recently, Zhao et al demonstrated the imaging enhancement and time gating effects on charge-coupled detector (CCD)-based spectral-domain optical coherence microscopy (SD-OCM) in turbid media by using optical parametric amplifier (OPA) with a type I BBO crystal [26]. In this study, we proposed and demonstrated a sensitivity enhancement method of the interferencebased signal detection on a SS-OCT system through FOPA and parametric BD.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity enhancement in swept-source optical coherence tomography by parametric balanced detector and amplifier

Kang¹,

Wei²,

Li³

et al. 2016

Biomed. Opt. Express

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We proposed a sensitivity enhancement method of the interference-based signal detection approach and applied it on a swept-source optical coherence tomography (SS-OCT) system through all-fiber optical parametric amplifier (FOPA) and parametric balanced detector (BD). The parametric BD was realized by combining the signal and phase conjugated idler band that was newly-generated through FOPA, and specifically by superimposing these two bands at a photodetector. The sensitivity enhancement by FOPA and parametric BD in SS-OCT were demonstrated experimentally. The results show that SS-OCT with FOPA and SS-OCT with parametric BD can provide more than 9 dB and 12 dB sensitivity improvement, respectively, when compared with the conventional SS-OCT in a spectral bandwidth spanning over 76 nm. To further verify and elaborate their sensitivity enhancement, a bio-sample imaging experiment was conducted on loach eyes by conventional SS-OCT setup, SS-OCT with FOPA and parametric BD at different illumination power levels. All these results proved that using FOPA and parametric BD could improve the sensitivity significantly in SS-OCT systems.

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Enhancement of optical coherence microscopy in turbid media by an optical parametric amplifier

Cited by 6 publications

References 48 publications

Ultrafast laser-scanning time-stretch imaging at visible wavelengths

Ultrafast laser-scanning time-stretch imaging at visible wavelengths

Retroreflective‐type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography

Sensitivity enhancement in swept-source optical coherence tomography by parametric balanced detector and amplifier

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