Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo

Zhang, Linghua; Zhang, Meirong; Li, Jiaoqing; Cao, Ting; Tian, Xiaoli; Zhou, Fengzhen

doi:10.1016/j.rvsc.2008.02.006

Cited by 30 publications

(11 citation statements)

References 26 publications

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“…After intramuscular and intranasal administration, CpG ODN enhanced the activity of a ND vaccine in chickens; increasing the systemic antigen-specific IgG levels in serum (T-cell proliferation), and mucosal (IgA) levels when administered intranasally. Specific-pathogen-free chickens covaccinated with ND vaccines and at least 100 mg of CpG ODN by either route were protected from challenge with an otherwise lethal dose of virulent NDV (Zhang et al, 2007(Zhang et al, , 2008. Vaccines containing CpG ODNs can be applied either systemically or via the mucosa, have good safety profiles, increase the immunogenicity of co-administered vaccines by improving the function of professional antigenpresenting cells, and boost the humoral and cellular vaccine-specific immune responses, highlighting their potential to be used as effective adjuvants for NDV and other poultry vaccines (Vleugels et al, 2002).…”

Section: Vaccines Utilizing Toll-like Receptor Ligands As Adjuvantsmentioning

confidence: 99%

Newcastle disease vaccines—A solved problem or a continuous challenge?

Dimitrov

Afonso

et al. 2017

Veterinary Microbiology

284

230

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Newcastle disease (ND) has been defined by the World Organisation for Animal Health as infection of poultry with virulent strains of Newcastle disease virus (NDV). Lesions affecting the neurological, gastrointestinal, respiratory, and reproductive systems are most often observed. The control of ND must include strict biosecurity that prevents virulent NDV from contacting poultry, and also proper administration of efficacious vaccines. When administered correctly to healthy birds, ND vaccines formulated with NDV of low virulence or viral-vectored vaccines that express the NDV fusion protein are able to prevent clinical disease and mortality in chickens upon infection with virulent NDV. Live and inactivated vaccines have been widely used since the 1950's. Recombinant and antigenically matched vaccines have been adopted recently in some countries, and many other vaccine approaches have been only evaluated experimentally. Despite decades of research and development towards formulation of an optimal ND vaccine, improvements are still needed. Impediments to prevent outbreaks include uneven vaccine application when using mass administration techniques in larger commercial settings, the difficulties associated with vaccinating free-roaming, multi-age birds of village flocks, and difficulties maintaining the cold chain to preserve the thermo-labile antigens in the vaccines. Incomplete or improper immunization often results in the disease and death of poultry after infection with virulent NDV. Another cause of decreased vaccine efficacy is the existence of antibodies (including maternal) in birds, which can neutralize the vaccine and thereby reduce the effectiveness of ND vaccines. In this review, a historical perspective, summary of the current situation for ND and NDV strains, and a review of traditional and experimental ND vaccines are presented.

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Section: Vaccines Utilizing Toll-like Receptor Ligands As Adjuvantsmentioning

confidence: 99%

Newcastle disease vaccines—A solved problem or a continuous challenge?

Dimitrov

Afonso

et al. 2017

Veterinary Microbiology

284

230

View full text Add to dashboard Cite

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“…Gomis et al (2003Gomis et al ( , 2004 demonstrated that prophylactic treatment of chickens with class B CpG ODN enhanced host immunity to numerous pathogens such as Escherichia coli. A number of reports regarding the effects of ODNs on chicken cells cultured in vitro (He et al 2003, 2006, Schwarz et al 2007 or as a vaccine adjuvant (Linghua et al 2007, Zhang et al 2008 have been published. However, little information is available about DNA induced stimulation of chicken leukocytes in vivo.…”

Section: Introductionmentioning

confidence: 99%

Impact of CpG oligodeoxynucleotide stimulation on percentage of T and B cells in chicken

Chrząstek¹,

Piasecki²,

Wieliczko³

2013

Polish Journal of Veterinary Sciences

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“…The induction of immune responses following mucosal immunisation usually depends on the co-administration of appropriate adjuvants (Zhang et al, 2008). Adjuvants are substances that, when co-administered with antigen, can modulate antigen-specific immune responses.…”

Section: Discussionmentioning

confidence: 99%

The B subunits of cholera and Escherichia coli heat-labile toxins enhance the immune responses in mice orally immunised with a recombinant live P-fimbrial vaccine for avian pathogenic E. coli

Jawale

Lee

2014

Acta Veterinaria Hungarica

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This study aimed to investigate the adjuvant effect of recombinant attenuated Salmonella expressing cholera toxin B subunit (CTB) and Escherichia coli heat-labile enterotoxin B subunit (LTB) for the P-fimbriae subunit-based vaccine of avian pathogenic E. coli (APEC) in a murine model. The PapA-specific sIgA and IgG responses were significantly enhanced after immunisation with the Salmonella-PapA vaccine in the presence of CTB or LTB. The group immunised with the Salmonella-LTB strain promoted Th1-type immunity, whereas that immunised with the Salmonella-CTB strain produced Th2-type immunity. We concluded that both Salmonella-CTB and -LTB strains can enhance the immune response to PapA, and that the LTB strain may be a more effective adjuvant for APEC vaccination, which requires higher Th1-type immunity for protection. Thus, our findings provide evidence that immunisation with an adjuvant, LTB, is one of the strategies of developing effective vaccines against P-fimbriated APEC.

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Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo

Cited by 30 publications

References 26 publications

Newcastle disease vaccines—A solved problem or a continuous challenge?

Newcastle disease vaccines—A solved problem or a continuous challenge?

Impact of CpG oligodeoxynucleotide stimulation on percentage of T and B cells in chicken

The B subunits of cholera and Escherichia coli heat-labile toxins enhance the immune responses in mice orally immunised with a recombinant live P-fimbrial vaccine for avian pathogenic E. coli

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