Enhancement of Mitochondrial Oxidative Stress and Up-regulation of Antioxidant Protein Peroxiredoxin III/SP-22 in the Mitochondria of Human Pre-eclamptic Placentae

Involvement of estrogen-related receptor-γ and mitochondrial content in intrauterine growth restriction and preeclampsia

“…Moreover, it has been demonstrated that mitochondrial DNA content, morphology, respiratory activity, and apoptosis are abnormal in IUGR and/or PE placentas (13,15,41,42). Altogether, these results suggest that placental mitochondrial dysfunction is involved in the pathogenesis of IUGR and PE.…”

“…Moreover, a recent study showed that the impairment of mitochondrial function in mice (using mitochondrial inhibitors) was associated with lower placental and fetal weights (11). Last, anomalies in mitochondrial DNA content, activity, and ultrastructure have been described in both IUGR and PE placentas (12)(13)(14)(15). Taken as a whole, these observations suggest that mitochondria have a predominant role in IUGR and PE.…”

Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?

“…Mitochondria contain two forms of peroxiredoxin (PRX) (Oberley et al, 2001): PRX III (Chang et al, 2004; Shibata et al, 2003) and PRX V (Seo et al, 2000). Peroxiredoxins use thioredoxin to decompose hydrogen peroxide, producing water and oxidized thioredoxin.…”

Preeclamptic placental stress and over expression of mitochondrial HSP70

“…Increased lipid peroxides (LPOs) and reduced antioxidant activity may contribute to the development of complications during preeclampsia (2). A growing body of evidence indicates that the pathogenesis of preeclampsia is closely associated with oxidative stress occurring in mitochondria (3). Mitochondria are the ''energy factory'' of cells and maintenance of this activity by preservation of protein content and function is a key aspect at the cellular level (4).…”