Enhancement of IGF-2-induced neurite outgrowth by IGF-binding protein-2 and osteoglycin in SH-SY5Y human neuroblastoma cells

Jeong, Eun Young; Kim, Sujoeng; Jung, Soonwoong; Kim, Gyeongwha; Son, Hyeonwi; Lee, Dong Hoon; Roh, Gu Seob; Kang, Sang Soo; Cho, Gyeong Jae; Choi, Wan Sung; Kim, Hyun Joon

doi:10.1016/j.neulet.2013.05.038

Cited by 18 publications

(15 citation statements)

References 24 publications

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“…Furthermore, in a chronic depression model in mice, OGN expression decreased in the amygdala, an important regulator of emotional behavior in mice, showing higher immobility (and thus severely depressed mice), whereas control mice and stressed mice with lower immobility (less depressed mice) had similar OGN expression (82). Further studies showed a decrease in total length of dendrites of the central amygdala neurons in depressed mice and in vitro OGN‐enhanced neurite outgrowth, implying a role for OGN in neural outgrowth in this model (83).…”

Section: Ogn In Diseasementioning

confidence: 96%

The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?

2016

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Small leucine-rich proteoglycans are emerging as important regulatory proteins within the extracellular matrix, where they exert both structural and nonstructural functions and hence are modulators of numerous biological processes, such as inflammation, fibrosis, and cell proliferation. One proteoglycan in particular, osteoglycin (OGN), also known as mimecan, shows great structural and functional diversity in normal physiology and in disease states, therefore making it a very interesting candidate for the development of novel therapeutic strategies. Unfortunately, the literature on OGN is confusing, as it has different names, and different transcript and protein variants have been identified. This review will give a clear overview of the different structures and functions of OGN that have been identified to date, portray its central role in pathophysiology, and highlight the importance of posttranslational processing, such as glycosylation, for the diversity of its functions.-Deckx, S., Heymans, S., Papageorgiou, A.-P. The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease? FASEB J. 30, 2651-2661 (2016). www.fasebj.orgThe extracellular matrix is a complex network of structural and nonstructural matrix proteins with a fundamental role in development, homeostasis, and pathophysiology. Small leucine-rich proteoglycans (SLRPs) are proteoglycans present in the extracellular matrix, where they are involved in a wide range of processes such as inflammation, fibrosis, and cell proliferation (1-4). Given the diversity of SLRPs, these proteoglycans are interesting targets for matrix-related research. In particular, osteoglycin (OGN), a class III SLRP member with multiple glycosylation sites, has been shown to be involved in many physiological processes (e.g., collagen fibrillogenesis, cell proliferation, and development), and in diverse pathologic entities, such as cardiovascular disease, cancer, and eye disease. Despite extensive research on OGN, the literature is rather confusing, because different names have been used for OGN, such as osteoinductive factor or mimecan, and different transcript and protein variants have been identified. Moreover, posttranslational processing, such as glycosylation, paramount in providing diversity in structure and function, is often poorly described. Hence, an identified function of OGN is rarely annotated to a certain transcript or glycosylated protein variant, adding to the confusion. Therefore, the purpose of this review is to give a clear overview of the different structures and functions of OGN known so far, highlight the importance of its glycosylation for the diversity in function, and describe its central role during normal physiology and in different pathological conditions. OGN: A DECEITFUL DWARFSLRPs have leucine-rich repeats (LRRs) (5), which are conserved motifs that are present from bacteria to humans and are critical for many processes, such as proteinprotein interactions, signal transduction, cell adhesion, and DNA repair (5). ...

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Section: Ogn In Diseasementioning

confidence: 96%

The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?

2016

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“…Mimecan is a proteoglycan recently shown to be decreased in the amygdala in a model of chronic immobilization stress . Mimecan supports neurite outgrowth in human neuroblastoma cells . There was a 21% reduction of secretogranin‐1 (chromogranin B) in the SCSON samples.…”

Section: Discussionmentioning

confidence: 93%

“…However, to maintain quality we present 12 top ranked proteins that are novel to SCS mechanism research. These proteins are involved in mechanisms concerning neurosupport/neuroprotection clusterin (CLUS, UniProtKB P10909) , gelsolin (GELS, UniProtKB P06396) , mimecan (MIME, UniProtKB P20774) , angiotensinogen (ANGT, UniProtKB P01019) , secretogranin‐1 (SCG1, UniProtKB P05060) and amyloid beta A4 protein (A4, UniProtKB P05067) , synaptic plasticity/learning/memory apolipoprotein C1 (APOC1, UniProtKB P02654) , apolipoprotein E (APOE, UniProtKB P02649) , contactin‐1 (CNTN1, UniProtKB Q12860) and neural cell adhesion molecule L1‐like protein (NCHL1, UniProtKB O00533) , immune regulation/inflammation dickkopf‐related protein 3 (DKK3, UniProtKB Q9UBP4) or are neuropeptides with direct effect on nociceptive signaling neurosecretory protein VGF (VGF, UniProtKB O15240) . Some of the protein changes, such as VGF and angiotensinogen, show an apparent connection to previous pain research literature while others; such as the changes in apolipoprotein levels are more surprising.…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Stimulation Alters Protein Levels in the Cerebrospinal Fluid of Neuropathic Pain Patients: A Proteomic Mass Spectrometric Analysis

Lind

Khoonsari

Sjödin

et al. 2016

Neuromodulation: Technology at the Neural Interface

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“…This gene is involved in the assembly of synapses but was only detected to be differentially upregulated in SNF‐AP. Last, IGF2 was found to regulate the proliferation of neuronal cells and the outgrowth of neurons and neurites …”

Section: Resultsmentioning

confidence: 99%

“…Last, IGF2 was found to regulate the proliferation of neuronal cells 40 and the outgrowth of neurons and neurites. 41 Differentially downregualted mRNAs on SNF-AP and PDL According to the Pathway Studio analysis, the mRNAs with negative median change for both materials generated gene sets that are generally involved in the regulation of the cell cycle, primarily in chromosome stability (Supporting Information Table 6). However, the NSC differentiated on PDL produced two gene sets related to axon anterograde transport and stem cell fate commitment (Table III and Supporting Information Table 7).…”

Section: Differentially Upregulated Mrnas On Snf-ap and Pdlmentioning

confidence: 99%

The effect of chemically modified electrospun silica nanofiber on the mRNA and miRNA expression profile of neural stem cell differentiation

Mercado

Yeh

Chin

et al. 2016

J Biomedical Materials Res

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A detailed genomic and epigenomic analyses of neural stem cells (NSCs) differentiation in synthetic microenvironments is essential for the advancement of regenerative medicine and therapeutic treatment of diseases. This study identified the changes in mRNA and miRNA expression profile during NSC differentiation on an artificial matrix. NSCs were grown on a surface-modified, electrospun tetraethyl-orthosilicate nanofiber (designated as SNF-AP) by providing a 3D-environment for cell growth and differentiation. Differentially expressed mRNAs and miRNAs of NSC differentiated in this microenvironment were identified through microarray analysis. The genes and miRNA targets responsible for the differentiation fate of NSCs and neuron development process were determined using Ingenuity Pathway Analysis (IPA). SNF-AP enhanced the expression of genes that activates the proliferation, development, and outgrowth of neurons, differentiation and generation of cells, neuritogenesis, outgrowth of neurites, microtubule dynamics, formation of cellular protrusions, and long-term potentiation during NSC differentiation. On the other hand, PDL inhibited neuritogenesis, microtubule dynamics, and proliferation and differentiation of cells and activated the apoptosis function. Moreover, the nanomaterial promoted the expression of more let-7 miRNAs, which have vital roles in NSC differentiation. Overall, SNF-AP is biocompatible and applicable scaffold for NSC differentiation in the development of neural tissue engineering. These findings are useful in enhancing in vitro NSC differentiation potential for preclinical studies and future clinical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2730-2743, 2016.

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Enhancement of IGF-2-induced neurite outgrowth by IGF-binding protein-2 and osteoglycin in SH-SY5Y human neuroblastoma cells

Cited by 18 publications

References 24 publications

The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?

The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?

Spinal Cord Stimulation Alters Protein Levels in the Cerebrospinal Fluid of Neuropathic Pain Patients: A Proteomic Mass Spectrometric Analysis

The effect of chemically modified electrospun silica nanofiber on the mRNA and miRNA expression profile of neural stem cell differentiation

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