Enhancement of human neutrophil migration by prostaglandin E2

Epps, Dennis E. Van; Wiik, A; Garcia, M. R.; Williams, Ralph C.

doi:10.1016/0008-8749(78)90182-x

Cited by 31 publications

(3 citation statements)

References 12 publications

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“…PGS themselves are efficient vasodilators (Joyner 1977, Williams 1979 and possess chemokinetic and chemotactic properties (van Epps et al 1978, Till et al 1979. Our observation of the localization of PGE in endothelial cells as well as leucocytes may be the morphological expression of the vasoactive and chemotactic effects of PGE.…”

Section: Discussionmentioning

confidence: 59%

Prostaglandin E and the local immune response in chronic periodontal disease

Löning

Albers

Lisboa

et al. 1980

J of Periodontal Research

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The local immune reaction of progressive chronic periodontal disease may be particularly influenced by macrophages and macrophage‐derived factors. Among these substances the prostaglandins and lysosomal enzymes may play an important pathogenetic role. Parallel immunohistochemical and radioimmunological studies were done to investigate the relationships of the immune‐competent cells and the inflammatory mediators in gingival tissues. The radioimmunological analysis revealed that prostaglandin E increases markedly in the established gingival lesions. Immunohistochemically prostaglandin E was mainly localized within macrophage‐like cells. Cytoplasmic lysozyme could be detected in these cells, too. On the other hand, the B‐cell response is the prominent feature in established chronic periodontal disease. However, there is apparently a disturbed B‐cell reaction as indicated by the irregular IgG‐subclass pattern and by the production of mainly monomeric IgA. The possible interactions of macrophages and especially B‐cells via prostaglandin E‐mediated mechanisms are discussed.

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Section: Discussionmentioning

confidence: 59%

Prostaglandin E and the local immune response in chronic periodontal disease

Löning

Albers

Lisboa

et al. 1980

J of Periodontal Research

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“…While the role of PGE 2 in neutrophil function in BC is still being elucidated, activated neutrophils can also be a source of PGE 2 . Early literature suggested a role of PGE 2 in neutrophil migration in general (Van Epps et al ., 1978). In colonic epithelial cells, PGE 2 stimulates IL‐8 leading to neutrophil recruitment to TME, thus contributing to tumour progression and metastasis (Yu and Chadee, 1998; Hartman et al ., 2013; Wang et al ., 2015).…”

Section: Neutrophilsmentioning

confidence: 99%

Understanding the tumour micro‐environment communication network from an NOS2/COX2 perspective

Basudhar

Bharadwaj

Somasundaram

et al. 2018

British J Pharmacology

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Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of NO and PGE , respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra-tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro-environment. Recent studies have also established a key role of NOS2-COX2 in causing metabolic shift. This review provides an extensive overview of the role of NO and PGE in shaping communication between the tumour micro-environment composed of tumour and immune cells that in turn favours tumour progression and metastasis.

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“…Thromboxane B,, the metabolite of the short-lived throm boxane Ao, HETE and HHT, the main products of platelet arachidonate metabo lism, have all been shown to stimulate leu cocyte chemotaxis [8,14], PGE2, a prosta glandin released by platelets, can also en hance leucocyte responses to other chemo taxins [27] although it does not influence cell movement itself.…”

Section: Discussionmentioning

confidence: 99%

Complement Activation by Rat Platelets: Its Significance to Inflammation in the Rat

Walker¹

1979

Int Arch Allergy Immunol

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Generation of chemotactic activity in rat plasma or serum by aggregated rat platelets or by an extract of lysed platelets has been demonstrated. Chemotactic activity was not generated from serum either in the absence of an intact complement system or by platelet lysate pre-incubated with soya bean trypsin inhibitor. The significance of these observations is discussed in relation to some recent work on the role of platelets in inflammation.

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Enhancement of human neutrophil migration by prostaglandin E2

Cited by 31 publications

References 12 publications

Prostaglandin E and the local immune response in chronic periodontal disease

Prostaglandin E and the local immune response in chronic periodontal disease

Understanding the tumour micro‐environment communication network from an NOS2/COX2 perspective

Complement Activation by Rat Platelets: Its Significance to Inflammation in the Rat

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