Enhancement of host defense by Y-25510, (±)-3-[4-(2-dimethylamino-1-methylethoxy) phenyl]-1H-pyrazolo[3, 4-b]pyridine-1-acetic acid, a novel synthetic compound. A comparison with recombinant human granulocyte colony-stimulating factor in 5-fluorouracil-treated mice
These findings that leukocyte and platelet counts never increased, despite the increment of the IL-1beta and IL-6 production after the administration of Y-25510, may be explained in part by the negative feedback mechanism induced by IL-10.
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