Enhancement of graft bone healing by intermittent administration of human parathyroid hormone (1–34) in a rat spinal arthrodesis model

Abe, Yuichiro; Takahata, Masahiko; Ito, Manabu; Irie, Kazuharu; Abumi, Kuniyoshi; Minami, Akio

doi:10.1016/j.bone.2007.06.025

Cited by 81 publications

(53 citation statements)

References 46 publications

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“…12). Our findings from the qualitative study of histological images correspond to the main principal bone's recovery stages reported by other researchers in rats [32][33][34][35][36].…”

Section: Osseous Experimentssupporting

confidence: 88%

In vivo degradation behavior and biological activity of some new Mg–Ca alloys with concentration's gradient of Si for bone grafts

Trincă

Fântânariu

Solcan

et al. 2015

Applied Surface Science

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“…12). Our findings from the qualitative study of histological images correspond to the main principal bone's recovery stages reported by other researchers in rats [32][33][34][35][36].…”

Section: Osseous Experimentssupporting

confidence: 88%

In vivo degradation behavior and biological activity of some new Mg–Ca alloys with concentration's gradient of Si for bone grafts

Trincă

Fântânariu

Solcan

et al. 2015

Applied Surface Science

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“…To identify relevant literature, we used a sensitive search of the most common databases for published medical literature, including Ovid MEDLINE 1 and PubMed. The search strings used were periosteum, structural bone graft, cortical bone graft, allograft, and autograft.…”

Section: Search Strategy and Criteriamentioning

confidence: 99%

“…Specifically administration of the amino terminal fragment PTH 1-34 demonstrated stimulatory effects on healing in various animal models including fracture-healing models [3,45,66,96] and bone-grafting models [1,35]. The mechanism by which PTH stimulates bone healing is not well understood.…”

Section: Design Considerations For Functional Tissue Engineering Of Pmentioning

confidence: 99%

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

Zhang

Awad

O’Keefe

et al. 2008

Clin Orthop Relat Res

200

165

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Autograft is superior to both allograft and synthetic bone graft in repair of large structural bone defect largely due to the presence of multipotent mesenchymal stem cells in periosteum. Recent studies have provided further evidence that activation, expansion and differentiation of the donor periosteal progenitor cells are essential for the initiation of osteogenesis and angiogenesis of donor bone graft healing. The formation of donor cell-derived periosteal callus enables efficient host-dependent graft repair and remodeling at the later stage of healing. Removal of periosteum from bone autograft markedly impairs healing whereas engraftment of multipotent mesenchymal stem cells on bone allograft improves healing and graft incorporation. These studies provide rationale for fabrication of a biomimetic periosteum substitute that could fit bone of any size and shape for enhanced allograft healing and repair. The success of such an approach will depend on further understanding of the molecular signals that control inflammation, cellular recruitment as well as mesenchymal stem cell differentiation and expansion during the early phase of the repair process. It will also depend on multidisciplinary collaborations between biologists, material scientists and bioengineers to address issues of material selection and modification, biological and biomechanical parameters for functional evaluation of bone allograft healing.

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“…Substantial efforts have been focused on developing therapies to conserve bone mass and reduce fracture risks but there has been little emphasis on studying osteoporosis bone defect healing. Since these defects cannot heal spontaneously several therapeutic approaches have been used including autologous bone transplantation (Abe et al, 2007). The amount of autogenous bone is limited and transplantation can lead to severe complication such as infection and nonunion at the donor and recipient sites.…”

Section: Introductionmentioning

confidence: 99%

Combination of bone tissue engineering and BMP‐2 gene transfection promotes bone healing in osteoporotic rats

Tang

Lin

et al. 2008

Cell Biology International

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Enhancement of graft bone healing by intermittent administration of human parathyroid hormone (1–34) in a rat spinal arthrodesis model

Cited by 81 publications

References 46 publications

In vivo degradation behavior and biological activity of some new Mg–Ca alloys with concentration's gradient of Si for bone grafts

In vivo degradation behavior and biological activity of some new Mg–Ca alloys with concentration's gradient of Si for bone grafts

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

Combination of bone tissue engineering and BMP‐2 gene transfection promotes bone healing in osteoporotic rats

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