In vivo  degradation behavior and biological activity of some new Mg–Ca alloys with concentration's gradient of Si for bone grafts

Trincă, Lucia Carmen; Fântânariu, Mircea; Solcan, Carmen; Trofin, A.; Burtan, L. C.; Acatrinei, Dumitru; Stanciu, Sergiu; Istrate, Bogdan; Munteanu, Corneliu

doi:10.1016/j.apsusc.2015.03.136

Cited by 19 publications

(36 citation statements)

References 35 publications

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“…The specific histological stains showed the intense and active bone formation after 2 weeks of implantation, whereas after the 4th week, the bone remodeling process had already started. X-Ray and computed tomography (CT) registered the presence of experimentally created defect in the tibia and revealed some of the bone-specific recovery stages in relation with the biodegradation process of the implant sample [ 50 ].…”

Section: Mg In Orthopedic Practicementioning

confidence: 99%

Magnesium-based biodegradable alloys: Degradation, application, and alloying elements

Pogorielov

Husak

Solodivnik

et al. 2017

Interventional Medicine and Applied Science

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In recent years, the paradigm about the metal with improved corrosion resistance for application in surgery and orthopedy was broken. The new class of biodegradable metal emerges as an alternative for biomedical implants. These metals corrode gradually with an appropriate host response and release of corrosion products. And it is absolutely necessary to use essential metals metabolized by hosting organism with local and general nontoxic effect. Magnesium serves this aim best; it plays the essential role in body metabolism and should be completely excreted within a few days after degradation. This review summarizes data from Mg discovery and its first experimental and clinical application of modern concept of Mg alloy development. We focused on biodegradable metal application in general surgery and orthopedic practice and showed the advantages and disadvantages Mg alloys offer. We focused on methods of in vitro and in vivo investigation of degradable Mg alloys and correlation between these methods. Based on the observed data, a better way for new alloy pre-clinical investigation is suggested. This review analyzes possible alloying elements that improve corrosion rate, mechanical properties, and gives the appropriate host response.

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Section: Mg In Orthopedic Practicementioning

confidence: 99%

Magnesium-based biodegradable alloys: Degradation, application, and alloying elements

Pogorielov

Husak

Solodivnik

et al. 2017

Interventional Medicine and Applied Science

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“…Seven studies were excluded for failing to report on any of the six outcome measures for the systematic review. After excluding six conference abstracts, five duplicate studies and 26 studies with fracture animal model as research objective, 30 animal studies of bone defect repair with biodegradable metals were included, with 25 in English [ [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] ] and five in Chinese [ [80] , [81] , [82] , [83] , [84] ] ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Biodegradable metals for bone defect repair: A systematic review and meta-analysis based on animal studies

Zhang

Jiang

Shang

et al. 2021

Bioactive Materials

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Biodegradable metals are promising candidates for bone defect repair. With an evidence-based approach, this study investigated and analyzed the performance and degradation properties of biodegradable metals in animal models for bone defect repair to explore their potential clinical translation. Animal studies on bone defect repair with biodegradable metals in comparison with other traditional biomaterials were reviewed. Data was carefully collected after identification of population, intervention, comparison, outcome, and study design (PICOS), and following the inclusion criteria of biodegradable metals in animal studies. 30 publications on pure Mg, Mg alloys, pure Zn and Zn alloys were finally included after extraction from a collected database of 2543 publications. A qualitative systematic review and a quantitative meta-analysis were performed. Given the heterogeneity in animal model, anatomical site and critical size defect (CSD), biodegradable metals exhibited mixed effects on bone defect repair and degradation in animal studies in comparison with traditional non-degradable metals, biodegradable polymers, bioceramics, and autogenous bone grafts. The results indicated that there were limitations in the experimental design of the included studies, and quality of the evidence presented by the studies was very low. To enhance clinical translation of biodegradable metals, evidence-based research with data validity is needed. Future studies should adopt standardized experimental protocols in investigating the effects of biodegradable metals on bone defect repair with animal models.

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“…Aligning with other elements can inhibit early weight loss, healing, bone thickening, and inflammation, and magnesium alloy surfaces can reduce the rate of degradation until the healing period. The addition of Sn, Si, Zr and Zn can improve maximum traction resistance and elongation at failure, while combining with Ca, Sr and Mn will cause acceleration of degradation [1,4,[16][17][18][19]. Mg is the easiest structural metal to machine, and stable final dimensions are easy to achieve.…”

Section: Alloying With Other Materialsmentioning

confidence: 99%

Topical Notions About in Vivo Analysis for Degradable Biomaterials with Utility in Human Body

Istrate

Vololeniuc

Munteanu

et al. 2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. Based on the biodegradable biomaterial development, there are numerous studies demonstrating partial or total aspects that have ultimately led to their use in many fields, especialy in medicine. This study summarizes the latest information on the development of degradable biomaterials based on magnesium, especially used in in vivo tissue compatibility assessment. The biomaterial compatibility assessment combines with the development of medical devices, this study following evolutionary parameters and integration of implants for human use. One of the most important parameters is the efficiency with which the medical device works near to the maximum potential. In conclusion, our study aims to broadly present the in vivo analysis of biodegradable biomaterials based on magnesium.

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In vivo degradation behavior and biological activity of some new Mg–Ca alloys with concentration's gradient of Si for bone grafts

Cited by 19 publications

References 35 publications

Magnesium-based biodegradable alloys: Degradation, application, and alloying elements

Magnesium-based biodegradable alloys: Degradation, application, and alloying elements

Biodegradable metals for bone defect repair: A systematic review and meta-analysis based on animal studies

Topical Notions About in Vivo Analysis for Degradable Biomaterials with Utility in Human Body

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