Enhancement of glucose uptake in muscular cell by soybean charged peptides isolated by electrodialysis with ultrafiltration membranes (EDUF): Activation of the AMPK pathway

Roblet, Cyril; Doyen, Alain; Amiot, Jean; Pilon, Geneviève; Marette, André; Bazinet, Laurent

doi:10.1016/j.foodchem.2013.09.108

Cited by 52 publications

(30 citation statements)

References 25 publications

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“…28 Moreover, it has been reported that an improved glucose uptake effect might be related to specific low molecular weight peptides (between 300-400 kDa). 28,29 To the best of our knowledge, this is the first study reporting the positive effect of peptides from chicken hydrolysates on glucose uptake. In addition to the glucose uptake, the fractions F1-F8 were tested for the effect on metabolic activity of the cells by measuring the ATP present in the cell cultures.…”

Section: Effect Of Peptide Fractions On Cellular Glucose Uptake and Mmentioning

confidence: 87%

Peptides from chicken processing by-product inhibit DPP-IV and promote cellular glucose uptake: potential ingredients for T2D management

et al. 2019

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Section: Effect Of Peptide Fractions On Cellular Glucose Uptake and Mmentioning

confidence: 87%

Peptides from chicken processing by-product inhibit DPP-IV and promote cellular glucose uptake: potential ingredients for T2D management

et al. 2019

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“…[2]. A high dietary intake of soybeans can reduce the risk of breast cancer and coronary heart disease and exerts anti-diabetic effects by enhancing glucose uptake [3][4][5]. Soybeans contain phytoalexin compounds, such as glyceollin, genistein, luteolin, and daidzein.…”

Section: Introductionmentioning

confidence: 99%

Effects of Synergistic Inhibition on α-glucosidase by Phytoalexins in Soybeans

et al. 2019

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To determine the mechanism of action of the effects of phytoalexins in soybeans, we analyzed α-glucosidase inhibition kinetics using Michaelis–Menten plots and Lineweaver–Burk plots. The results showed that the type of inhibition with glyceollin was competitive, that of genistein was noncompetitive, that of daidzein was uncompetitive, and luteolin showed a mixed mode of action. The Ki values were determined using a Dixon plot as glyceollin, 18.99 μM; genistein, 15.42 μM; luteolin, 16.81 μM; and daidzein, 9.99 μM. Furthermore, potential synergistic effects between glyceollin and the three polyphenols were investigated. A combination of glyceollin and luteolin at a ratio of 3:7 exhibited synergistic effects on α-glucosidase inhibition, having a combination index (CI) of 0.64244, according to the CI–isobologram equation. Collectively, these results showed that a combination of glyceollin and luteolin has the potential to inhibit α-glucosidase activity via a synergistic mode of inhibition.

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“…EDUF was also successful in recovery and concentration of bioactive (e.g. antioxidant, antihypertensive and antidiabetic) peptides from a variety of protein hydrolysates, including soybean, salmon frame, rapeseed, flaxseed and rainbow trout frames (Doyen et al ., ; Roblet et al ., , ; He et al ., ; Suwal et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Selective separation and characterisation of dual ACE and DPP‐IV inhibitory peptides from rainbow trout (Oncorhynchus mykiss) protein hydrolysates

Ketnawa

Suwal

Huang

et al. 2018

Int J of Food Sci Tech

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Microwave pretreatment and hydrolysis were applied to rainbow trout (Oncorhynchus mykiss) by-products to produce bioactive peptides with dual in vitro angiotensin-I converting enzyme (ACE) and dipeptidylpeptidase IV (DPP-IV) inhibitory activities. Peptides were fractionated using the single step electrodialysis with ultrafiltration membrane (EDUF). Concentration of cationic peptides (CP) increased in the recovery solution, reaching 125 lg mL À1 after a 4-h treatment with migration rate of 15.68 AE 2.98 g m À2 h. CP fractions displayed ACE and DPP-IV I inhibitory properties, with IC 50 values of 0.0036 mg mL À1 and 1.23 mg mL À1 respectively. The bioactivity was attributed to the low molecular weight peptides (300-500 Da) recovered. CP exhibited non-competitive inhibition patterns for ACE and DPP-IV, which were dose dependent. These results showed that bioactive peptides can successfully be separated from complex hydrolysate mixtures by EDUF. The fractionated peptides can serve as potential functional food ingredients or nutraceuticals for the management of hypertension and diabetes. Fractionation of active peptides by electrodialysis with ultrafiltration membraneA detailed description of the EDUF cell and operating conditions used for fractionation in this study is given in Suwal et al. (2018). Briefly, the cell configuration

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Enhancement of glucose uptake in muscular cell by soybean charged peptides isolated by electrodialysis with ultrafiltration membranes (EDUF): Activation of the AMPK pathway

Cited by 52 publications

References 25 publications

Peptides from chicken processing by-product inhibit DPP-IV and promote cellular glucose uptake: potential ingredients for T2D management

Peptides from chicken processing by-product inhibit DPP-IV and promote cellular glucose uptake: potential ingredients for T2D management

Effects of Synergistic Inhibition on α-glucosidase by Phytoalexins in Soybeans

Selective separation and characterisation of dual ACE and DPP‐IV inhibitory peptides from rainbow trout (Oncorhynchus mykiss) protein hydrolysates

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