Enhancement of extraction efficiency of paclitaxel from biomass using ionic liquid-methanol co-solvents under acidic conditions

Kim, Gun-Joong; Kim, Jin-Hyun

doi:10.1016/j.procbio.2015.03.009

Cited by 29 publications

(14 citation statements)

References 25 publications

(36 reference statements)

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“…Paclitaxel (C 47 H 51 NO 14 ÁH 2 O) is a tetracyclic diterpenoid and antitumor agent with activity against ovarian, breast, lung, Kaposi's sarcoma and Prostrate cancers (Wall and Wani 1995;Vyas and Kadow 1995;Kim and Kim 2015). This drug acts as a promoter of tubulin polymerization and prevents microtubule depolymerization, both in vitro and in vivo which disrupts cell division, i.e., stabilization of the microtubules interferes with the G 2 and M phases of the cell cycle and those cellular activities involving microtubules (Carlier and Pantaloni 1983;Georg et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Microbial degradation of Paclitaxel using Citrobacter amalonaticus Rashtia isolated from pharmaceutical wastewater: kinetic and thermodynamic study

Zamani

Grakoee

Rakhshaee

2016

World J Microbiol Biotechnol

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Paclitaxel is a highly toxic anticancer agent which is used in a wide range against ovarian, breast, lung, and prostate cancers. Paclitaxel is manufactured recently in the north of Iran which may lead to the introduction of the drug into the environment via pharmaceutical wastewater. To our knowledge, Paclitaxel degradation is currently performed using physicochemical methods and biological degradation of Paclitaxel has not been reported. In this study, a Paclitaxel degrading bacterium was isolated from pharmaceutical wastewater for the first time. The bacterium was identified using biochemical and molecular assays and its Paclitaxel degradation potential was evaluated using High Performance Liquid Chromatography (HPLC). In addition, kinetic and thermodynamic study of Paclitaxel degradation at different experimental conditions was performed. A Citrobacter species named as C. amalonaticus Rashtia able to degrade and utilize Paclitaxel as the sole carbon source was isolated. The isolated strain tolerated high level concentration of Paclitaxel (0.4 mg/mL) in liquid culture media and was able to degrade spillage-level concentrations of the drug (0.01-0.1 mg/mL) with 87-93 % efficacy under aerobic condition. Kinetic and thermodynamic study at different pHs (4.0, 7.0 and 10.0) and temperatures (285, 295 and 310 K) revealed that Paclitaxel degradation is a non-spontaneous process and the highest rate constant was observed in the basic condition and at the highest temperature. The ΔG values at 285, 295 and 310 K were determined 103.3, 105.9 and 109.9 kJ/mol, respectively. In addition, The ΔH and activation energy (Ea) of the process were determined +28.7 kJ/mol and +30.87 kJ/mol, respectively.

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Section: Introductionmentioning

confidence: 99%

Microbial degradation of Paclitaxel using Citrobacter amalonaticus Rashtia isolated from pharmaceutical wastewater: kinetic and thermodynamic study

Zamani

Grakoee

Rakhshaee

2016

World J Microbiol Biotechnol

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“…또한, 계속되는 적응증(류마티스성 관절염, 알츠하이 머 치료) 및 처방방법의 개발로 파클리탁셀 수요는 계속 늘어날 전 망이다 [2,3]. 파클리탁셀의 주요 생산 방법에는 주목나무(yew tree) 에서 직접 추출하는 방법, 주목나무에서 전구체를 얻어 반합성하는 방법, 주목나무에서 캘러스(callus)를 유도하여 식물세포를 배양하여 얻는 방법이 있다 [4][5][6].…”

Section: 서 론unclassified

Ultrasound-Assisted Liquid-Liquid Extraction for Recovery of Paclitaxel from Plant Cell Cultures

Ha¹,

Kim²

2016

Korean Chemical Engineering Research

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− In this study, an efficient ultrasound-assisted liquid-liquid extraction process was developed for recovering of paclitaxel from plant cell cultures. The optimal ultrasonic power and operating time were 250 W and 15 min at fixed ratio of bottom phase, methylene chloride to top phase, MeOH (25%, v/v). Under the optimal conditions developed in the present method, most of the paclitaxel (~92%) was recovered from crude extract by a single extraction step. Due to the synergistic effect of ultrasound by the addition of inorganic salt, an appropriate inorganic salt concentration and the ultrasonic power were found to be required for the effective recovery of paclitaxel using ultrasound-assisted liquid-liquid extraction.

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“…Paclitaxel (PCX) ((2α,4α,5β,7β,10β,13α)‐4,10‐bis(acetyloxy)‐13‐{[(2 R ,3 S )‐3‐(benzoylamino)‐2‐hydroxy‐3‐phenylpropanoyl]oxy}‐1,7‐dihydroxy‐9‐oxo‐5,20‐epoxytax‐11‐en‐2‐yl benzoate), a natural product extracted from specific yaw trees on the Pacific Coast, is another anticancer pharmaceutical that has been widely used in chemotherapy treatments such as lung, breast, and ovarian cancers. This drug is especially prescribed for breast cancer patients after their breast surgery . Several analytical methods for quantitative extraction and analysis of these pharmaceuticals have been reported in the literature such as HPLC with photodiode array detection, LLE–LC–MS/MS, automated solid–liquid extraction with HPLC and fluorescence detection, ionic‐liquid‐based liquid‐phase extraction, dispersive liquid–liquid microextraction, magnetic SPE, and multiple SPME .…”

Section: Introductionmentioning

confidence: 99%

Extraction and determination of trace amounts of three anticancer pharmaceuticals in urine by three‐phase hollow fiber liquid‐phase microextraction based on two immiscible organic solvents followed by high‐performance liquid chromatography

Nazaripour

Yamini

Bagheri

2018

J of Separation Science

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An automated three-phase hollow fiber liquid-phase microextraction based on two immiscible organic solvents followed by high-performance liquid chromatography with UV-Vis detection method was applied for the extraction and determination of exemestane, letrozole, and paclitaxel in water and urine samples. n-Dodecane was selected as the supported liquid membrane and its polarity was justified by trioctylphosphine oxide. Acetonitrile was used as an organic acceptor phase with desirable immiscibility having n-dodecane. All the effective parameters of the microextraction procedure such as type of the organic acceptor phase, the supported liquid membrane composition, extraction time, pH of the donor phase, hollow fiber length, stirring rate, and ionic strength were evaluated and optimized separately by a one variable at-a-time method. Under the optimal conditions, the linear dynamic ranges were 1.8-200 (R = 0.9991), 0.9-200 (R = 0.9987) and 1.2-200 μg/L (R = 0.9983), and the limits of detection were 0.6, 0.3, and 0.4 μg/L for exemestane, letrozole, and paclitaxel, respectively. To evaluate the capability of the proposed method in the analysis of biological samples, three different urinary samples were analyzed under the optimal conditions. The relative recoveries of the three pharmaceuticals were in the range of 91-107.3% for these three analytes.

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Enhancement of extraction efficiency of paclitaxel from biomass using ionic liquid-methanol co-solvents under acidic conditions

Cited by 29 publications

References 25 publications

Microbial degradation of Paclitaxel using Citrobacter amalonaticus Rashtia isolated from pharmaceutical wastewater: kinetic and thermodynamic study

Microbial degradation of Paclitaxel using Citrobacter amalonaticus Rashtia isolated from pharmaceutical wastewater: kinetic and thermodynamic study

Ultrasound-Assisted Liquid-Liquid Extraction for Recovery of Paclitaxel from Plant Cell Cultures

Extraction and determination of trace amounts of three anticancer pharmaceuticals in urine by three‐phase hollow fiber liquid‐phase microextraction based on two immiscible organic solvents followed by high‐performance liquid chromatography

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