Enhancement of dissolution rate of piroxicam by electrospinning technique

Abstract

The use of electrospun nanofibers to enhance dissolution of poorly soluble drugs could be a novel strategy in future for pharmaceutical applications. In the present work electrospun nanofibers were prepared as a novel system for enhancing the delivery of piroxicam, a non-steroidal anti-inflammatory drug (NSAID). These nanofibers were prepared from polyvinyl pyrrolidone (PVP) (pharmaceutical grade), a biodegradable polymer, to obtain a solution with drug:polymer ratio of 1:4. The release rate of the piroxicam nanofibers was studied in simulated gastric fluid. Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) are used to evaluate the chemical and physical nature. The results showed that the release rates were twice increased in comparison with the pure drug. However, the blend of drug and polymer could be varied to optimize the release rates depending upon the need and formulation

Biosurfactant Production Using Mutant Strains of Pseudomonas aeruginosa and Bacillus subtilis from Agro-industrial Wastes

“…This was according to literature 26 with some modifications. The stocks, 0.1, 0.2, 0.4, 0.6, 0.8, 1.0, 1.2, 1.4, and 1.6 mL of solutions were separately transferred into 10 mL volumetric flasks and volumes made up to 10 ml with distilled water using sterile micropipette to obtain concentrations of 5, 10, 20, 30, 40, 50, 60, 70 and 80 µg/mL respectively.…”

Toxico-Neurological Effects of Piroxicam in Monogastric Animals

“…10 This may be due to the enhancement of dissolution rate by electro-spinning technique. 11 When administered orally, it was 100% bioavailable and maximum concentrations (3.1 ± 1.0 hours) were achieved quickly. 12 Piroxicam-β-cyclodextrin has a gastrointestinal safety profile that is better than that shown by uncomplexed piroxicam.…”

“…1 The up-and-down procedure was adopted in 1981 and revised many times. The method involves the use of less number of animals (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), is faster, and its findings are relatively comparable to the findings from other methods. 2 Piroxicam is a benzothiazine possessing an enolic 4-hydroxy substituent, prostaglandin inhibitor, with active enterohepatic circulation resulting in prolonged half-life (30-85 hours), making it possible for single daily effective dose (20 mg).…”

Scale‐up of electrospinning technology: Applications in the pharmaceutical industry

“…During the last decades, electrospun fibers have become attractive oral drug delivery systems, mostly because they can improve the absorption of poorly soluble drugs by enhancing the dissolution rate of drug molecules through amorphization. The very efficient amorphization effect of ES is due to the immediate evaporation of the solvent, which results in solid solution of the drug in the applied matrix (Begum et al, 2012;Nagy et al, 2012;Vigh et al, 2013;Vrbata, Berka, Stránská, Doležal, & Lázníc ˇek, 2014). Electrospun fiber-based amorphous solid dispersions are able to maintain an incorporated active ingredient in the amorphous physical form for prolonged periods of time because of their homogeneous drug distribution within the matrix and ability to inhibit molecular motion (Yu, Li, Williams, & Zhao, 2018).…”