Enhancement of cancer therapy efficacy by trastuzumab-conjugated and pH-sensitive nanocapsules with the simultaneous encapsulation of hydrophilic and hydrophobic compounds

Particle size control and the interactions between drug and stabilizers in an amorphous nanosuspension system

“…PVA is widely used as a stabilizer in many nanoparticle systems, e.g., iron oxide, silver nanoparticles and nanocapsules [27][28][29]. Theoretically, PVP&PVA could be applied to controlling the size of secondary particles or change their surface state in such nanoparticle systems.…”

Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy

“…Several research groups had reported research on co-delivery of DOX, CDDP, or PTX with Herceptin (Lee et al, 2009;Liu & Feng, 2011;Mi et al, 2013). NDCDS with pH sensitiveness can enhance cancer therapy efficacy with the simultaneous encapsulation of hydrophilic and hydrophobic compounds (Chiang et al, 2014). Lee et al reported cationic micelles assembled from copolymer, P(MDS-co-CES), to co-deliver PTX and Herceptin to achieve targeting delivery of PTX to HER2/neu-overexpressing human breast cancer cells.…”

Nanotechnology Approaches for Cancer Immunotherapy and Immunomodulation

“…For example, surface decorated albumin nanoparticles (Taheri et al 2012 ), lipid nanocapsules (Sánchez-Moreno et al 2013 ), poly(vinyl alcohol) nanocapsules (Chiang et al 2014 ), polymalic acid (PMLA) nanobioconjugates (Ding et al 2013 ), and P(LA-co -TMCC)-g -PEG-furan micelles (Owen et al 2013 ) all incorporate monoclonal antibodies for improved interactions with cells expressing HER2. However, the contribution of the monoclonal antibodies themselves to the effi cacy of the therapy has not been taken into consideration, thus disregarding any potential therapeutic effect due to the mAbs in combination with the encapsulated antitumoral drugs.…”