Nanotechnology Approaches for Cancer Immunotherapy and Immunomodulation

Fuente, María de la; Langer, Robert; Alonso, María José

doi:10.1007/978-3-319-08084-0_8

Cited by 4 publications

(3 citation statements)

References 164 publications

(213 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanocapsules are versatile systems in which different types of drugs, from small molecular weight anticancer drugs to high molecular weight hydrophilic biomolecules (i.e. gene therapies and proteins) can be associated [ 19 , 40 , 41 ], and can hold potential for this particular application.…”

Section: Discussionmentioning

confidence: 99%

Selective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node

et al. 2016

View full text Add to dashboard Cite

BackgroundMetastases are the most common reason of cancer death in patients with solid tumors. Lymph nodes, once invaded by tumor cells, act as reservoirs before cancer cells spread to distant organs. To address the limited access of intravenously infused chemotherapeutics to the lymph nodes, we have developed PEGylated polyglutamic acid nanocapsules (PGA-PEG NCs), which have shown ability to reach and to accumulate in the lymphatic nodes and could therefore act as nanotransporters. Once in the lymphatics, the idea is that these nanocapsules would selectively interact with cancer cells, while avoiding non-specific interactions with immune cells and the appearance of subsequent immunotoxicity.ResultsThe potential of the PGA-PEG NCs, with a mean size of 100 nm and a negative zeta potential, to selectively reach metastatic cancer cells, has been explored in a novel 3D model that mimics an infiltrated lymph node. Our 3D model, a co-culture of cancer cells and lymphocytes, allows performing experiments under dynamic conditions that simulate the lymphatic flow. After perfusion of the nanocarriers, we observe a selective interaction with the tumor cells. Efficacy studies manifest the need to develop specific therapies addressed to treat metastatic cells that can be in a dormant state.ConclusionsWe provide evidence of the ability of PGA-PEG NCs to selectively interact with the tumor cells in presence of lymphocytes, highlighting their potential in cancer therapeutics. We also state the importance of designing precise in vitro models that allow performing mechanistic assays, to efficiently develop and evaluate specific therapies to confront the formation of metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Selective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node

et al. 2016

View full text Add to dashboard Cite

show abstract

“… 191 , 192 And given their unique interactions with the immune system, nanoparticles are being evaluated as therapeutic vaccines, targeted monoclonal antibody treatments, and activators of cell based immune therapies. 193 The ability to deliver multimodal therapeutic agents can potentially provide synergistic therapies, leading to decreased dosing and associated toxicities. Improvements in materials design are providing new functionalities for therapeutic encapsulation and surface ligand conjugations for tumor targeting.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

“…The evolving sophistication of nanotherapy systems allows for addressing heterogeneity and biological diversity that are now known to exist within the most aggressive cancers. For instance, new nanoparticle techniques are being used to target cancer stem cells which may be linked to treatment resistance. , And given their unique interactions with the immune system, nanoparticles are being evaluated as therapeutic vaccines, targeted monoclonal antibody treatments, and activators of cell based immune therapies . The ability to deliver multimodal therapeutic agents can potentially provide synergistic therapies, leading to decreased dosing and associated toxicities.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies

Ediriwickrema

Saltzman

2015

ACS Biomater. Sci. Eng.

153

121

View full text Add to dashboard Cite

Cancer continues to be a prevalent and lethal disease, despite advances in tumor biology research and chemotherapy development. Major obstacles in cancer treatment arise from tumor heterogeneity, drug resistance, and systemic toxicities. Nanoscale delivery systems, or nanotherapies, are increasing in importance as vehicles for antineoplastic agents because of their potential for targeting and multifunctionality. We discuss the current field of cancer therapy and potential strategies for addressing obstacles in cancer treatment with nanotherapies. Specifically, we review the strategies for rationally designing nanoparticles for targeted, multimodal delivery of therapeutic agents.

show abstract

Nano-based vaccination and their administration routes in cancer immunotherapy

Ahmed

2024

Nanomedicine in Cancer Immunotherapy

View full text Add to dashboard Cite

Nanotechnology Approaches for Cancer Immunotherapy and Immunomodulation

Cited by 4 publications

References 164 publications

Selective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node

Selective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node

Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies

Nano-based vaccination and their administration routes in cancer immunotherapy

Contact Info

Product

Resources

About