Enhancement of brain activation during trial-and-error sequence learning in early PD

Mentis, Marc J.; Dhawan, Vijay; Nakamura, Tomoya; Ghilardi, M. F.; Feigin, Andrew; Edwards, Christine; Ghez, Claude; Eidelberg, David

doi:10.1212/01.wnl.0000044154.92143.dc

Cited by 81 publications

(87 citation statements)

References 36 publications

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“…Functional neuroimaging studies have repeatedly shown changes in activation in motor and premotor areas in PD during performance of motor tasks, particularly in the supplementary motor area. [23][24][25][26][27][28][29] Dysfunction of medial frontal areas, which presumably results from altered basal ganglia interactions due to nigrostriatal dopaminergic loss, plays a role in impaired motor performance (ie, hypokinesia). 1,30 This type of functional cortical deafferentation is supported by brain imaging studies showing diminished regional blood flow in the supplementary motor area 24 and the prefrontal region.…”

Section: Discussionmentioning

confidence: 99%

Altered Diffusion in the Frontal Lobe in Parkinson Disease

Kendi¹,

Lehericy²,

Luciana³

et al. 2008

AJNR Am J Neuroradiol

176

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Section: Discussionmentioning

confidence: 99%

Altered Diffusion in the Frontal Lobe in Parkinson Disease

Kendi¹,

Lehericy²,

Luciana³

et al. 2008

AJNR Am J Neuroradiol

176

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show abstract

“…Vermis activation also occurs during reward tasks in Parkinson's and in attention deficit hyperactivity disorder patients, but not in comparison subjects (Ernst et al, 2003;Goerendt et al, 2004;Kunig et al, 2000). In addition, increased cerebellar (and vermis) activation occur to support working memory function in frontotemporal dementia, Parkinson's Disease, and schizophrenia, (Mentis et al, 2003;Meyer-Lindenberg et al, 2001;Rombouts et al, 2003). Thus, several domains of frontal lobe function pertinent to addiction-related behaviors appear to be supported by cerebellum and vermis.…”

Section: Cerebellar Connectivity To Dopamine Circuitrymentioning

confidence: 95%

Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Anderson

Maas

Frederick

et al. 2005

Neuropsychopharmacol

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Although the cerebellum is increasingly being viewed as a brain area involved in cognition, it typically is excluded from circuitry considered to mediate stimulant-associated behaviors since it is low in dopamine. Yet, the primate cerebellar vermis (lobules II-III and VIII-IX) has been reported to contain axonal dopamine transporter immunoreactivity (DAT-IR). We hypothesized that DAT-IR-containing vermis areas would be activated in cocaine abusers by cocaine-related cues and, in healthy humans, would accumulate DAT-selective ligands. We used BOLD fMRI to determine whether cocaine-related cues activated DAT-IR-enriched vermis regions in cocaine abusers and positron emission tomography imaging of healthy humans to determine whether the DAT-selective ligand [ 11 C]altropane accumulated in those vermis regions. Cocaine-related cues selectively induced BOLD activation in lobules II-III and VIII-IX in cocaine users, and, at early time points after ligand administration, we found appreciable [ 11 C]altropane accumulation in lobules VIII-IX, possibly indicating DAT presence in this region. These data suggest that parts of cerebellar vermis mediate cocaine's persisting and acute effects. In light of prior findings illustrating vermis connections to midbrain dopamine cell body regions, established roles for the vermis as a locus of sensorimotor integration and motor planning, and findings of increased vermis activation in substance abusers during reward-related and other cognitive tasks, we propose that the vermis be considered one of the structures involved in cocaine-and other incentive-related behaviors.

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“…The involvement of the cerebellum and dentate nuclei in both the PDRP and PDCP is compatible with the presence of distinct motor and non-motor efferent channels from the dentate nuclei to the striatum and cerebral cortex (cf., Dum et al, 2002;Hoshi et al, 2005). The latter may be particularly critical in the performance of complex tasks, as demonstrated by increased cerebellar-prefrontal activity in PD patients during trial-and-error sequence learning (Mentis et al, 2003). By contrast, the prominent increases in basal ganglia-thalamic activity that are characteristic of the PDRP (Moeller et al, 1999;cf., Carbon et al, 2003a) did not contribute to the PDCP spatial topography.…”

Section: Anatomical/functional Basis For the Pdcp Topographymentioning

confidence: 99%

Metabolic brain networks associated with cognitive function in Parkinson's disease

et al. 2007

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The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal spatial covariance pattern involving basal ganglia thalamocortical pathways. By contrast, little is known about the functional networks that underlie cognitive dysfunction in this disorder. To identify such patterns, we studied 15 non-demented PD patients using FDG PET and a voxel-based network modeling approach. We detected a significant covariance pattern that correlated (p< 0.01) with performance on tests of memory and executive functioning. This PD-related cognitive pattern (PDCP) was characterized by metabolic reductions in frontal and parietal association areas and relative increases in the cerebellar vermis and dentate nuclei. To validate this pattern, we analyzed data from 32 subsequent PD patients of similar age, disease duration and severity. Prospective measurements of PDCP activity predicted memory performance (p<0.005), visuospatial function (p<0.01), and perceptual motor speed (p<0.005) in this validation sample. PDCP scores additionally exhibited an excellent degree of test-retest reliability (intraclass correlation coefficient, ICC=0.89) in patients undergoing repeat FDG PET at an 8-week interval. Unlike the PD-related motor pattern, PDCP expression was not significantly altered by antiparkinsonian treatment with either intravenous levodopa or deep brain stimulation (DBS). These findings substantiate the PDCP as a reproducible imaging marker of cognitive function in PD. Because PDCP expression is not altered by routine antiparkinsonian treatment, this measure of network activity may prove useful in clinical trials targeting the progression of non-motor manifestations of this disorder.

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Enhancement of brain activation during trial-and-error sequence learning in early PD

Cited by 81 publications

References 36 publications

Altered Diffusion in the Frontal Lobe in Parkinson Disease

Altered Diffusion in the Frontal Lobe in Parkinson Disease

Cerebellar Vermis Involvement in Cocaine-Related Behaviors

Metabolic brain networks associated with cognitive function in Parkinson's disease

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