Altered Diffusion in the Frontal Lobe in Parkinson Disease

Kendi, Ayşe Tuba Karagülle; Lehericy, Stéphane; Luciana, Mónica; Uğurbil, Kâmil; Tuite, Paul J.

doi:10.3174/ajnr.a0850

Cited by 176 publications

(101 citation statements)

References 37 publications

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“…Both identified anatomical networks are strikingly similar to regions reported in previous studies in PD and healthy controls as being functionally connected to the posterior putamen (Helmich et al, 2010; Tziortzi et al, 2014). The prefrontal regions identified in our study are also consistent with regions showing diffusion alterations in PD patients (Kendi et al, 2008). The anatomical networks are also consistent with recent findings reporting these regions to be associated with altered activity and connectivity in PD patients during execution and attention to novel versus automatic movements (Wu et al, 2014).…”

Section: Discussionsupporting

confidence: 87%

Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson’s Symptoms

Dukart

Sambataro

Bertolino

2017

Front. Aging Neurosci.

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Degeneration of dopaminergic neurons is a hallmark of Parkinson’s disease. However, its link to Parkinson’s disease symptoms remains unclear. Striatal resting state functional connectivity differentiates between Parkinson’s disease patients and healthy controls and might be a potential mediator of the effects of striatal dopaminergic degeneration onto Parkinson’s disease symptoms. Here, we evaluated the relationship between dopaminergic deficits, striatal functional connectivity (SFC) at rest and different Parkinson’s disease clinical symptoms in the largest currently established cohort of de novo Parkinson’s disease patients. We show that SFC is an independent predictor of symptom severity in Parkinson’s disease in addition to striatal dopaminergic deficits. Furthermore, we find that distinct SFC networks are associated with symptoms reflecting the ability to perform daily routine automatized motor tasks and clinician-rated Parkinson’s disease motor symptoms. We find that reduced SFC is a major and independent predictor of Parkinson’s disease symptoms going beyond the mere reflection of striatal dopaminergic input loss. These findings indicate the high value of SFC as a clinically relevant biomarker in Parkinson’s disease.

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Section: Discussionsupporting

confidence: 87%

Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson’s Symptoms

Dukart

Sambataro

Bertolino

2017

Front. Aging Neurosci.

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“…Two recent meta-analyses (Shao et al 2015; Yu et al 2015) investigated volume changes in patients with PD compared to controls using a plethora of studies (Burton et al 2004; Cordato et al 2005; Nagano-Saito et al 2005; Summerfield et al 2005; Beyer et al 2007; Ramirez-Ruiz et al 2007; Karagulle Kendi et al 2008; Camicioli et al 2009; Jubault et al 2009; Martin et al 2009; Pereira et al 2009; Sanchez-Castaneda et al 2009; Tir et al 2009; Dalaker et al 2010; Kostic et al 2010; Nishio et al 2010; Cerasa et al 2011; Focke et al 2011a, b; Meppelink et al 2011; Compta et al 2012; Fernandez-Seara et al 2012; Hong et al 2012; Ibarretxe-Bilbao et al 2012; Tessitore et al 2012a ; Lee et al 2013a; O’Callaghan et al 2013; Ellfolk et al 2014; Menke et al 2014; Sehm et al 2014) using VBM. Reduced GM volume was noted in the frontal lobe including bilateral middle and inferior frontal gyri and the left precentral gyrus, the parietal lobe including the left superior parietal lobule and precuneus, the occipital lobe including bilateral cuneus, and the limbic lobe including the left anterior cingulate in one meta-analysis (Shao et al 2015).…”

Section: Diagnosis Of Pdmentioning

confidence: 99%

Magnetic resonance imaging for the diagnosis of Parkinson’s disease

et al. 2017

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The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology and error rates in the clinical diagnosis can be high even at specialized centres. Despite several limitations, magnetic resonance imaging (MRI) has undoubtedly enhanced the diagnostic accuracy in the differential diagnosis of neurodegenerative parkinsonism over the last three decades. This review aims to summarize research findings regarding the value of the different MRI techniques, including advanced sequences at high- and ultra-high-field MRI and modern image analysis algorithms, in the diagnostic work-up of Parkinson’s disease. This includes not only the exclusion of alternative diagnoses for Parkinson’s disease such as symptomatic parkinsonism and atypical parkinsonism, but also the diagnosis of early, new onset, and even prodromal Parkinson’s disease.

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“…49 Another study found decreased fractional anisotropy in the frontal lobes in PD patients without cognitive impairment and with no evidence of brain volume loss. 50 …”

Section: Imaging White Matter Lesionsmentioning

confidence: 99%

White matter lesions in Parkinson disease

2011

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Pure vascular parkinsonism without evidence of nigral Lewy body pathology may occur as a distinct clinicopathological entity, but a much more frequent occurrence is the comorbid presence of age-associated white matter lesions (WMLs) in idiopathic Parkinson disease (PD). WMLs are associated with motor and cognitive symptoms in otherwise normal elderly individuals. Comorbid WMLs are, therefore, expected to contribute to clinical symptoms in PD. Studies of WMLs in PD differ with regard to methods of assessment of WML burden and the patient populations selected for analysis, but converging evidence suggests that postural stability and gait motor functions are predominantly affected. WMLs are described to contribute to dementia in Alzheimer disease, and emerging but inconclusive evidence indicates similar effects in PD. In this article, we review the literature addressing the occurrence and impact of WMLs in PD, and suggest that WMLs may exacerbate or contribute to some motor and cognitive deficits associated with PD. We review existing and emerging methods for studying white matter pathology in vivo, and propose future research directions.

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Altered Diffusion in the Frontal Lobe in Parkinson Disease

Cited by 176 publications

References 37 publications

Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson’s Symptoms

Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson’s Symptoms

Magnetic resonance imaging for the diagnosis of Parkinson’s disease

White matter lesions in Parkinson disease

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