Enhancement of bone formation with a synthetic matrix containing bone morphogenetic protein-2 by the addition of calcium citrate

Wang, Wei; Chen, Qingyu; Li, Xiucui; Zhang, Wei; Peng, Lei; Wang, Liming; Lin, Zhong-Qin; Xu, Huazi; ShiFeng, Song; Zhang, Xiaolei; Cheng, Siyao; Kou, Dongquan; Lv, Chuanzhu; Yu, Zhaoning

doi:10.1007/s00167-012-1953-2

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…One of the reactions highlighted is the need to increase transport of citrate from the extracellular space to the cytosol. It has been shown that growing cells on citrate rich materials encourages osteogenesis (Wang et al, 2013;Irizarry et al, 2017), this match with the literature is encouraging. This discovery regarding citrate in combination with the enrichment of the exchange/demand reactions subsystem also suggests that other transporters may be interesting targets for future investigation when it comes to searching for new ways to increase osteogenesis of MSCs.…”

Section: Proposed Methods To Increase Osteogenesissupporting

confidence: 78%

Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction

Sigmarsdóttir

McGarrity

Yurkovich

et al. 2021

Front. Cell Dev. Biol.

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Since their initial discovery in 1976, mesenchymal stem cells (MSCs) have been gathering interest as a possible tool to further the development and enhancement of various therapeutics within regenerative medicine. However, our current understanding of both metabolic function and existing differences within the varying cell lineages (e.g., cells in either osteogenesis or adipogenesis) is severely lacking making it more difficult to fully realize the therapeutic potential of MSCs. Here, we reconstruct the MSC metabolic network to understand the activity of various metabolic pathways and compare their usage under different conditions and use these models to perform experimental design. We present three new genome-scale metabolic models (GEMs) each representing a different MSC lineage (proliferation, osteogenesis, and adipogenesis) that are biologically feasible and have distinctive cell lineage characteristics that can be used to explore metabolic function and increase our understanding of these phenotypes. We present the most distinctive differences between these lineages when it comes to enriched metabolic subsystems and propose a possible osteogenic enhancer. Taken together, we hope these mechanistic models will aid in the understanding and therapeutic potential of MSCs.

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Section: Proposed Methods To Increase Osteogenesissupporting

confidence: 78%

Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction

Sigmarsdóttir

McGarrity

Yurkovich

et al. 2021

Front. Cell Dev. Biol.

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show abstract

“…Biomaterials including hydroxyapatite, hydroxyapatite, tricalcium phosphate, and calcium sulfate can be used as an rhBMP-2 carrier matrix because BMP-2 needs a carrier to be activated in the tissue destination. BMP-2 is released into the surrounding environment and enhances the formation of new bone [17].…”

Section: Figure 7: Magnetic Resonance Imaging Have Been Taken 8 Years After Surgerymentioning

confidence: 99%

Core Decompression and Biological Treatment in Osteonecrosis of the Hip due to Systemic Lupus Erythematosus, 8-year Follow-up: A Case Report

Рhatomy¹,

Dilogo²

2021

Open Access Maced J Med Sci

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BACKGROUND: Osteonecrosis most commonly affects the femoral head, especially in middle-aged adults. It can be caused by trauma, chronic inflammation, or infection. It leads to collapse of the entire femoral head and culminates with total hip replacement. CASE REPORT: A 29-year-old female with systemic lupus erythematosus (SLE) had a chief complaint of bilateral hip pain. She was diagnosed with early osteonecrosis of the femoral head (FICAT stage II) using magnetic resonance imaging and core decompression surgery was performed using three small diameter (4 mm) drillings and added biological treatment. She was evaluated with a visual analog scale (VAS), Harris hip score (HHS), and plain radiography in the pre-operative stage and post-operative follow-up. RESULTS: Functional outcome at 8-year follow-up showed improvement with significantly decreased VAS (pre-operative: 5, post-operative: 0), significant improvement of HHS from 52.725 points (poor) pre-operative to 92.025 points (excellent) post-operative, and subsided femoral head lesion. CONCLUSIONS: Surgical decompression and biological treatment result in decreased intraosseous pressure and enhanced osteogenesis. It can restrict the SLE disease progression and limit the number of cell death.

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Comparison of stem cells derived from periosteum and bone marrow of jaw bone and long bone in rabbit models

Park

Bae

Lee

et al. 2012

Tissue Eng Regen Med

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Enhancement of bone formation with a synthetic matrix containing bone morphogenetic protein-2 by the addition of calcium citrate

Cited by 7 publications

References 28 publications

Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction

Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction

Core Decompression and Biological Treatment in Osteonecrosis of the Hip due to Systemic Lupus Erythematosus, 8-year Follow-up: A Case Report

Comparison of stem cells derived from periosteum and bone marrow of jaw bone and long bone in rabbit models

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