Enhancement of bleomycin—iron free radical damage to DNA by antioxidants and their inhibition of lipid peroxidation

Gutteridge, John M.C.; Xiao-Chang, Fu

doi:10.1016/0014-5793(81)80022-1

Cited by 67 publications

(11 citation statements)

References 13 publications

(4 reference statements)

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“…Gossypol was found also to possess antioxidant properties in mammalian liver microsomes (Kovacic, 2003), which may shield lipids against oxidative damage. It is a powerful antagonist of ironinduced lipid peroxidation in rat liver microsomes (Gutteridge and Xia-Chang, 1981). Other reports showed that GAA produces an increase in spermatozoal lipid peroxidation as evidenced by a steep rise in TBARS in the human sperm cells (Fornes et al, 1993).…”

Section: Effect Of Gossypol Acetic Acid On the Biochemical Parametersmentioning

confidence: 98%

Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats

El-Sharaky

Newairy

Elguindy

et al. 2010

Food and Chemical Toxicology

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Section: Effect Of Gossypol Acetic Acid On the Biochemical Parametersmentioning

confidence: 98%

Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats

El-Sharaky

Newairy

Elguindy

et al. 2010

Food and Chemical Toxicology

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“…CTX is an anticancer chemotherapeutic agent that is widely used in the treatment of various types of human cancers, such as hepatocellular carcinoma, medulloblastoma, and carcinomas of the breast, lung, and cervix [ 21 ]. However, a high dosage of CTX often leads to severe side effects, which greatly affect the quality of life of patients [ 22 , 23 ]. By detection of some indexes of immunity, we found that the 5P had significant effects on improvement of immunity compared with CTX.…”

Section: Discussionmentioning

confidence: 99%

The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer

et al. 2017

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Glutathione peroxidase (GPx) is an antioxidant protein containing selenium. Owing to the limitations of native GPx, considerable efforts have been made to develop GPx mimics. Here, a short 5-mer peptides (5P) was synthesized and characterized using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Enzyme coupled assays were used to evaluate GPx activity. The cell viability and apoptosis of H22 cells were tested, and mice bearing H22 cell-derived tumors were used to determine the effects of 5P on tumor inhibition. In comparison with other enzyme models, 5P provided a suitable substrate with proper catalytic site positions, resulting in enhanced catalytic activity. In our mouse model, 5P showed excellent inhibition of tumor growth and improved immunity. In summary, our findings demonstrated the design and synthesis of the small 5P molecule, which inhibited tumor growth and improved immunity. Notably, 5P could inhibit tumor growth without affecting normal growth. Based on these advantages, the novel mimic may have several clinical applications.

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“…(61) So, pro-oxidant effects of supplements are a problem in the food industry. (62) The possible advantages of taking a mixture of herbal medicines are to reduce the dosage of each medicine and to achieve a greater (synergistic) effect. (63) For example, single use β-carotene, α-tocopherol (vitamin E) or ascorbic acid could act as pro-oxidant but mixture of the three compounds exhibited greater protective effects than any individual compound.…”

Section: Discussionmentioning

confidence: 99%

Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans

Moriwaki

Kato

et al. 2013

J. Clin. Biochem. Nutr.

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Excessive generation of reactive oxygen species within cells results in oxidative stress. Furthermore, accumulation of reactive oxygen species has been shown to reduce cell longevity. Many dietary supplements are believed to have anti-aging effects. The herb mixture KPG-7 contains several components with antioxidant activity. We aim to clarify the mechanisms responsible for the antioxidant activity of KPG-7 and to establish whether KPG-7 has an anti-aging effect. We examined whether dietary supplementation with KPG-7 could provide protection against oxidative stress, extend lifespan, and delay aging in Caenorhabditis elegans (C. elegans). We found that KPG-7 extended lifespan and delayed aging in adult C. elegans. The expression of oxidation resistance 1 protein was induced by juglone and this effect was significantly suppressed in KPG-7-treated. In addition, the amount of oxidized protein was significantly lower in KPG-7-treated worms than untreated worms. Furthermore, locomotive activity was increased in C. elegans at 3 days of age following the treatment with KPG-7. On the other hand, the level of cellular ATP was lower at 3 days of age in worms treated with KPG-7 than in untreated worms. KPG-7 increases lifespan and delays aging in C. elegans, well corresponding to its activity to protect against oxidative stress.

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Enhancement of bleomycin—iron free radical damage to DNA by antioxidants and their inhibition of lipid peroxidation

Cited by 67 publications

References 13 publications

Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats

Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats

The Small Glutathione Peroxidase Mimic 5P May Represent a New Strategy for the Treatment of Liver Cancer

Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans

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