Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats

El-Sharaky, A.S.; Newairy, Al-Sayeda A.; Elguindy, Nihal M.; Elwafa, A.A.

doi:10.1016/j.fct.2010.09.004

Cited by 62 publications

(62 citation statements)

References 68 publications

(52 reference statements)

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“…As testosterone supports spermatogenesis, sperm maturation and sexual function, thus any disruption in testosterone biosynthesis can adversely affects male fertility [68]. In another study of El-Sharaky et al [69], the use of a Leydig cell toxicant resulted in decrease of testosterone level in rats, resulting in increased germ cell apoptosis. In addition, testosterone can affect Sertoli cells function and germinal cell degeneration; thus, dislocation could take place due Sertoli cells dysfunction and decreased testosterone level, the latter enhance premature detachment of epithelial cells [70,71].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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“…As alterações encontradas no ciclo redox da glutationa em nossos experimentos vão de encontro aos apresentados por El-Sharaky et al (2010), que avaliou o efeito do gossipol em ratos que receberam doses de 5, 10 e 20mg/kg de peso vivo via intraperitoneal, pois foram observados aumentos progressivos nas concentrações de GSH e reduções nos níveis de GSSG. Essas divergências são justificáveis em função do trabalho desenvolvido por Kovacic (2003) que mostrou que o gossipol apresenta dupla ação, ou seja, atua tanto como agente anti como pró-oxidante.…”

Section: Discussão E Conclusãounclassified

Mecanismos da intoxicação do fígado de rato causada pelo gossipol

Carvalho

Maioli

Mendes³

et al. 2013

Pesq. Vet. Bras.

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The liver plays a central role in metabolism due to its interposition between the digestive tract and the general circulation of the organism. It is also the main organ involved in biotransformation of exogenous substances (xenobiotics), with ability to convert hydrophobic compounds in water-soluble, more easily eliminated by the body. Gossypol is a toxic phenolic substance present in cotton seed (Gossypium sp.). Aiming to study the mechanisms involved in the hepatotoxicity of gossypol we evaluate its effects on the antioxidant system of rat liver performing an experiment that investigated the oxidative stress and the histopathological alterations. In this study, we used Wistar rats, divided into two groups, one that received canola oil (vehicle, Control group) and another that received gossypol at a dose of 40mg/kg body weight of the animal for 15 days (Treated group). The treatment with gossypol caused alterations in the activity of seric enzymes that indicate hepatic injury and a significant oxidative stress characterized by a decrease of reduced glutathione (GSH) levels and a consequent increase in oxidized glutathione (GSSG), including further damage to the plasma membrane and organelles showed by lipid peroxidation. The result of histopathological evaluation showed degeneration of the hepatocytes.

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“…Gossypol (2,2-bi(8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)) is a phenolic compound produced by the pigment glands in cotton stems, leaves, seeds and flower buds (Rogers et al, 2002;Kenar, 2006;Alexander et al, 2008;Soto-Blanco, 2008). This compound is known to affect male reproduction, inhibiting spermatogenesis and reducing spermatozoid motility and viability (Randel et al, 1992;Fornes et al, 1993;Brocas et al, 1997;Yuan & Shi, 2000;El-Sharaky et al, 2010). These effects were dose-and timedependent, but were reversed when gossypol was no longer ingested (Randel et al, 1992;Hassan et al, 2004).…”

Section: Introductionmentioning

confidence: 98%

“…Furthermore, it inhibits calcium influx and Mg-ATPase Ca-Mg-ATPase activity in the plasma membranes of spermatozoids (Breitbart et al, 1989;El-Sharaky et al, 2010), but an increase in the intracellular calcium concentration has also been reported (Cheng et al, 2003).…”

Section: Gossypol Promotes the Degeneration Of Chicken Ovarian Follicmentioning

confidence: 99%

Gossypol Promotes the Degeneration of Chicken Ovarian Follicles in Vitro

Gadelha

Lima

Melo

et al. 2016

Rev. Bras. Cienc. Avic.

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Gossypol, a phenolic compound produced by the pigment glands of cotton, is known to affect male reproduction. In females, exposure to gossypol has been associated with interference with the estrous cycle and embryo development. In laying hens fed cottonseed, gossypol was found to reduce egg production and weight and to cause discoloration of the egg yolk and/or albumen. It is probable that gossypol directly affects ovarian follicles, but this has not been confirmed experimentally yet. Thus, the aim of the present study was to determine if gossypol affected cultivated ovarian follicles of the chicken. Ovarian follicles of adult female chickens were cultivated with different concentrations of gossypol (0, 5, 10 and 20 μg/mL) and classified according to the stage of development as primordial, transitional, primary, secondary or antral, and as viable or atretic. The percentages of viable and atretic follicles in the ovaries cultivated for 24 hours in the presence of gossypol were significantly different from those of the controls for all types of follicles except for secondary follicles, but in all types after cultivation for 7 days. The percentage of viable follicles was higher than that of atretic follicles in ovaries cultivated without gossypol. In contrast, ovaries cultivated with gossypol showed a predominance of atretic follicles. Gossypol increased the proportion of atretic follicles at all stages of development in cultivated chicken ovaries. Thus, gossypol may affect ovarian follicular viability and maturation, which might interfere with female fertility.

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Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats

Cited by 62 publications

References 68 publications

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Mecanismos da intoxicação do fígado de rato causada pelo gossipol

Gossypol Promotes the Degeneration of Chicken Ovarian Follicles in Vitro

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